Association rate between deep peritoneal endometriosis and other forms of the disease: pathogenetic implications
Abstract
BACKGROUND: It has been suggested recently that deep endometriosis and the other forms of the disease do not share a common pathogenetic mechanism. In this study, we hypothesize that, if this is true, deep peritoneal endometriosis and the other forms should not be significantly associated. METHODS: Clinical and surgical records of all women who were referred to the Department of Obstetrics and Gynecology, Clinica 'L.Mangiagalli' between January 1995 and June 2002 and who were diagnosed with deep peritoneal pelvic endometriosis at the time of surgery were retrieved. The concomitant presence of superficial endometriotic implants, endometriomas and pelvic adhesions was evaluated. A binomial probability distribution model was used to calculate the 95% confidence interval (95% CI) of the association rates. RESULTS: Ninety-three women with deep peritoneal endometriosis were identified. The presence of superficial endometriotic implants, endometriomas and pelvic adhesions was documented in 61.3% (95% CI 51.4-71.2%), 50.5% (95% CI 40.3-60.7%) and 74.2% (95% CI 65.3-83.1%) of patients with deep endometriotic nodules, respectively. Overall, deep peritoneal endometriosis was the only form of the disease in only 6.5% (95% CI 2.8-12.3%) of cases. No relevant differences regarding these associations were observed according to the location and the size of the deep endometriotic nodules. CONCLUSIONS: Results from this study do not support the hypothesis that deep endometriosis should be considered as a distinct entity of the disease.
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Deep, peritoneal, and ovarian endometriosis often occur simultaneously in the same individual.
“This might also explain that deep, peritoneal, and ovarian endometriosis often occur simultaneously in the same individual (275).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [275]
There is a high correlation between the presence of deep endometriosis and the presence of peritoneal and ovarian endometriosis.
“The high correlation between the presence of deep endometriosis and the presence of peritoneal and ovarian endometriosis raises the question whether they are three different entities with a common or different pathogenesis.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [21]
Deep endometriosis as the only form of disease in absence of other endometriotic lesions was present in only 6.5%.
“Deep endometriosis as the only form of disease in absence of other endometriotic lesions was present in only 6.5% (21).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [21]
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- Authors
- Somigliana, E.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Somigliana, E.
- ORCID
- Somigliana, E.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 168-171
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2135653031
- Cited by
- 115
- References
- 14
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 10 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 10 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 8
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- endometrioma, pelvic adhesions, endometriosis classification, endometriosis pathogenesis, association rate
- MeSH terms
- Tissue Adhesions, Adnexal Diseases, Adult, Cysts, Endometriosis, Female, Humans, Ovarian Diseases, Peritoneal Diseases, Retrospective Studies, Severity of Illness Index, Incidence, Confidence Intervals
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