Cited by 109Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsEndometriosis Research and Treatment

Polycystic ovary syndrome, oral contraceptives and metabolic issues: new perspectives and a unifying hypothesis

Nader, S., Diamanti-Kandarakis, E.·2007·Human Reproduction

Abstract

In the chronic treatment of polycystic ovary syndrome (PCOS), oral contraceptive pills (OCPs) are commonly used to induce regular menses, protect the endometrium and ameliorate androgenic symptoms. However, the long-term safety of OCP use in PCOS has not been established, and the literature reveals conflicting data concerning the metabolic effects of OCPs in this patient population, with outcomes ranging from improvement of glucose tolerance to the development of frank diabetes. This article presents new perspectives and a unifying hypothesis concerning the effects of OCPs on carbohydrate metabolism in PCOS and attempts to explain the divergent findings in published reports.

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Crossref · 10.1093/humrep/del407

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Authors
Nader, S., & Diamanti-Kandarakis, E.
Affiliations
Texas Medical Center (US)
Venue
Human Reproduction
Published
2006-11-10
Volume
22
Issue
2
Pages
317-322
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
OpenAlex
W2121670837
Cited by
109
References
60
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 12
FWCI
8.11
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords
polycystic ovary syndrome, oral contraceptives, metabolic effects, glucose tolerance, diabetes mellitus, carbohydrate metabolism, long-term safety, endometrial protection
MeSH terms
Contraceptives, Oral, Combined, Female, Humans, Insulin Resistance, Models, Biological, Polycystic Ovary Syndrome, Carbohydrate Metabolism, Lipid Metabolism

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