Polycystic ovary syndrome, oral contraceptives and metabolic issues: new perspectives and a unifying hypothesis
Abstract
In the chronic treatment of polycystic ovary syndrome (PCOS), oral contraceptive pills (OCPs) are commonly used to induce regular menses, protect the endometrium and ameliorate androgenic symptoms. However, the long-term safety of OCP use in PCOS has not been established, and the literature reveals conflicting data concerning the metabolic effects of OCPs in this patient population, with outcomes ranging from improvement of glucose tolerance to the development of frank diabetes. This article presents new perspectives and a unifying hypothesis concerning the effects of OCPs on carbohydrate metabolism in PCOS and attempts to explain the divergent findings in published reports.
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Oral contraceptive use may worsen glucose tolerance and lipid profiles in some cases and increase triglyceride levels.
“It can be seen that in some cases, the conditions may be worsened, and there will be the circulation of increased triglyceride levels [108].”
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- Authors
- Nader, S., & Diamanti-Kandarakis, E.
- Affiliations
- Texas Medical Center (US)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11-10
- Volume
- 22
- Issue
- 2
- Pages
- 317-322
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2121670837
- Cited by
- 109
- References
- 60
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 12
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, oral contraceptives, metabolic effects, glucose tolerance, diabetes mellitus, carbohydrate metabolism, long-term safety, endometrial protection
- MeSH terms
- Contraceptives, Oral, Combined, Female, Humans, Insulin Resistance, Models, Biological, Polycystic Ovary Syndrome, Carbohydrate Metabolism, Lipid Metabolism
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