Sibutramine has a positive effect on clinical and metabolic parameters in obese patients with polycystic ovary syndrome
Open accessAbstract
Objective To evaluate the effectiveness of sibutramine therapy alone and in combination with ethinyl estradiol-cyproterone acetate (EE-CPA) on the clinical and metabolic parameters of obese women with polycystic ovary syndrome (PCOS). Design Prospective randomized, controlled study. Setting Endocrinology and gynecology clinics. Patient(s) Forty obese women with PCOS. Intervention(s) Group 1 was treated with oral EE-CPA (35 microg-2 mg/day), group 2 with oral sibutramine (10 mg/day), and group 3 with a combination of EE-CPA plus sibutramine for 6 months. All groups were advised to consume a diet of 1200 kcal/day. Main outcome measurement(s) Measurements were performed before and 6 months after treatment of body mass index, waist-to-hip ratio, systolic and diastolic blood pressure, Ferriman-Gallwey hirsutism score, total testosterone, free testosterone, sex hormone-binding globulin, dihydroepiandrosterone sulfate (DHEAS), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, glucose and insulin during oral glucose tolerance test, and insulin sensitivity index; area under the curve for glucose and insulin were obtained from OGTT. Result(s) Body mass index, Ferriman-Gallwey hirsutism score, serum total testosterone, free testosterone, and DHEAS levels were significantly decreased and SHBG was significantly increased in all groups at the end of the study. WHR, diastolic blood pressure, and serum triglyceride level were significantly reduced only in the sibutramine group. Conclusion(s) Sibutramine might have a positive effect on hyperandrogenemia, and clinical and metabolic risk factors for cardiovascular disease in obese women with PCOS.
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Consuming unsaturated fatty acids enhances insulin sensitivity in people with type 2 diabetes or obesity and in healthy people.
“Consuming unsaturated fatty acids has been shown to enhance insulin sensitivity in people with type 2 diabetes or obesity and in healthy people [99, 100].”
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- Authors
- Sabuncu, T., Harma, M., Harma, M., Nazligul, Y., & Kilic, F.
- Affiliations
- Harran University (TR)
- Corresponding author
- Sabuncu, Tevfik
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 80
- Issue
- 5
- Pages
- 1199-1204
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2158102992
- Cited by
- 78
- References
- 4
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2020: 1 · 2018: 1 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 7
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- sibutramine, polycystic ovary syndrome, obesity, combination therapy, hyperandrogenemia, hirsutism, testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, insulin sensitivity, insulin resistance, dyslipidemia, cardiovascular risk factors, weight loss
- MeSH terms
- Adult, Androgen Antagonists, Appetite Depressants, Blood Pressure, Body Constitution, Body Weight, Cyclobutanes, Diastole, Drug Combinations, Drug Therapy, Combination, Ethinyl Estradiol, Female, Hirsutism, Hormones, Humans, Obesity, Polycystic Ovary Syndrome, Triglycerides, Treatment Outcome, Cyproterone Acetate
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