The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
Abstract
In this contribution we put forward a novel hypothesis concerning the aetiology of Type 2 (non-insulin dependent) diabetes mellitus. The concept underlying our hypothesis is that poor foetal and early post-natal nutrition imposes mechanisms of nutritional thrift upon the growing individual. We propose that one of the major long-term consequences of inadequate early nutrition is impaired development of the endocrine pancreas and a greatly increased susceptibility to the development of Type 2 diabetes. In the first section we outline our research which has led to this hypothesis. We will then review the relevant literature. Finally we show that the hypothesis suggests a reinterpretation of some findings and an explanation of others which are at present not easy to understand. The controversy concerning the relative roles of insulin deficiency and insulin resistance in Type 2 diabetes continues unresolved. Despite the early demonstration that obese people have elevated plasma insulin concentrations1 many studies over the years have failed to control adequately for the influence of obesity. Another difficulty with the interpretation of plasma insulin concentrations is that sustained hyperglycaemia could have detrimental effects on insulin secretion.
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Cites
INFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES
BARKER, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91340-1 · Cited by 2,892
Self-citationFetal and placental size and risk of hypertension in adult life.
Barker, D. J., Bull, A. R., Osmond, C., & Simmonds, S. J. (1990) · BMJ · doi:10.1136/bmj.301.6746.259 · Cited by 1,728
Self-citationHyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465
Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*
Perley, M. J., & Kipnis, D. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105685 · Cited by 917
Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay
Karam, J. H., Grodsky, G. M., Forsham, P. H., & McWilliams, N. B. (1963) · Diabetes · doi:10.2337/diab.12.3.197 · Cited by 591
Congenital susceptibility to NIDDM. Role of intrauterine environment
Pettitt, D. J., Aleck, K. A., Baird, H. R., Carraher, M. J., Bennett, P. H., & Knowler, W. C. (1988) · Diabetes · doi:10.2337/diab.37.5.622 · Cited by 530
Nagi, D. K., Hendra, T. J., Ryle, A. J., Cooper, T. M., Temple, R. C., Clark, P. M. S., Schneider, A. E., Hales, C. N., & Yudkin, J. S. (1990) · Diabetologia · doi:10.1007/bf00404140 · Cited by 198
Self-citationYoshioka, N., Kuzuya, T., Matsuda, A., Taniguchi, M., & Iwamoto, Y. (1988) · Diabetologia · doi:10.1007/bf02341503 · Cited by 175
Cited by
Zhou, B., Lu, Y., Hajifathalian, K., Bentham, J., Di Cesare, M., Danaei, G., Bixby, H., Cowan, M., Ali, M., Taddei, C., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00618-8 · Cited by 4,311
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468
Self-citationTransgenerational epigenetic inheritance: myths and mechanisms
Heard, E., & Martienssen, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.02.045 · Cited by 1,864
A comprehensive review on metabolic syndrome
Kaur, J. (2014) · Cardiology Research and Practice · doi:10.1155/2014/943162 · Cited by 1,889
RetractedPancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
Metadata
- Authors
- Hales, C., & Barker, D.
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-10-01
- Volume
- 42
- Issue
- 5
- Pages
- 1215-1222
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2267668114
- Cited by
- 708
- References
- 8
- FWCI
- 56.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hales, C., & Barker, D. (2013). Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. International Journal of Epidemiology. https://doi.org/10.1093/ije/dyt133
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
