The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Challenge of Viral Reservoirs in HIV-1 Infection
Abstract
▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reservoirs for HIV-1. It is now clear that HIV-1 persists in a small reservoir of latently infected resting memory CD4+T cells, which shows minimal decay even in patients on highly active antiretroviral therapy (HAART). The persistence of virus in this reservoir is consistent with the biology of these cells and the long-term persistence of immunologic memory. The viral replication that continues in patients on suppressive HAART may also contribute to the stability of this reservoir. There may be other reservoirs, but the latent reservoir in resting CD4+T cells appears to be sufficient to guarantee lifetime persistence of HIV-1 in the majority of patients on current HAART regimens, and unless new approaches are developed, eradication will not be possible. The clinical implications of this and other HIV-1 reservoirs are discussed.
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Citations
Cites
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Self-citationQuantification of latent tissue reservoirs and total body viral load in HIV-1 infection
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Cited by
Siliciano, J. D., Kajdas, J., Finzi, D., Quinn, T. C., Chadwick, K., Margolick, J. B., Kovacs, C., Gange, S. J., & Siliciano, R. F. (2003) · Nature Medicine · doi:10.1038/nm880 · Cited by 1,703
Self-citationVpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
Hrecka, K., Hao, C., Gierszewska, M., Swanson, S. K., Kesik-Brodacka, M., Srivastava, S., Florens, L., Washburn, M. P., & Skowronski, J. (2011) · Nature · doi:10.1038/nature10195 · Cited by 1,200
“MDM were subjected to RNAi targeting DCAF1, SAMHD1 or non-targeting RNAi (NT1, NT2), and infected (1) or not (2) with SIV VLP loaded with SIVmac Vpx, 2 days later.”
MethodNanotechnological advances for the delivery of cns therapeutics.
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Redefining the Viral Reservoirs that Prevent HIV-1 Eradication
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Self-citationPrecise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies
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Metadata
- Authors
- Blankson, J. N., Persaud, D., & Siliciano, R. F.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2002-02
- Volume
- 53
- Issue
- 1
- Pages
- 557-593
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2117785982
- Cited by
- 627
- References
- 11
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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