The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Bacterial stress responses as determinants of antimicrobial resistance
Abstract
Bacteria encounter a myriad of stresses in their natural environments, including, for pathogens, their hosts. These stresses elicit a variety of specific and highly regulated adaptive responses that not only protect bacteria from the offending stress, but also manifest changes in the cell that impact innate antimicrobial susceptibility. Thus exposure to nutrient starvation/limitation (nutrient stress), reactive oxygen and nitrogen species (oxidative/nitrosative stress), membrane damage (envelope stress), elevated temperature (heat stress) and ribosome disruption (ribosomal stress) all impact bacterial susceptibility to a variety of antimicrobials through their initiation of stress responses that positively impact recruitment of resistance determinants or promote physiological changes that compromise antimicrobial activity. As de facto determinants of antimicrobial, even multidrug, resistance, stress responses may be worthy of consideration as therapeutic targets.
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Cites
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Cited by
Khezerlou, A., Alizadeh-Sani, M., Azizi-Lalabadi, M., & Ehsani, A. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.08.008 · Cited by 404
Bacterial Stress Responses during Host Infection
Fang, F. C., Frawley, E. R., Tapscott, T., & Vázquez-Torres, A. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.009 · Cited by 319
Pires, D., Melo, L., Vilas Boas, D., Sillankorva, S., & Azeredo, J. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.09.004 · Cited by 312
Antibiotic resistance: turning evolutionary principles into clinical reality
Andersson, D. I., Balaban, N. Q., Baquero, F., Courvalin, P., Glaser, P., Gophna, U., Kishony, R., Molin, S., & Tønjum, T. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa001 · Cited by 238
Dhar, R., Sägesser, R., Weikert, C., & Wagner, A. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mss253 · Cited by 126
Metadata
- Authors
- Poole, K.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05-22
- Volume
- 67
- Issue
- 9
- Pages
- 2069-2089
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2098992986
- Cited by
- 519
- References
- 20
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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