The novel oral glucan synthase inhibitor SCY-078 shows in vitro activity against sessile and planktonic Candida spp
Abstract
Objectives: We studied the antifungal activity of SCY-078 (an orally bioavailable 1,3-β -d- glucan synthesis inhibitor), micafungin and fluconazole against the planktonic and sessile forms of 178 Candida and non- Candida isolates causing fungaemia in patients recently admitted to a large European hospital. Methods: The in vitro activity of SCY-078, micafungin and fluconazole against the planktonic form of the isolates was assessed using EUCAST EDef 7.3 and CLSI M27-A3. Antibiofilm activity was assessed using the XTT reduction assay. Results: SCY-078 and micafungin showed potent in vitro activity against Candida and non- Candida isolates. The in vitro activity of both drugs was similar, but SYC-078 displayed significantly lower MIC values than micafungin against Candida parapsilosis and non- Candida isolates, whereas micafungin displayed significantly lower MIC values for the remaining species ( P <0.001). In contrast, SCY-078 and micafungin showed essentially the same activity against the biofilms with the exception of Candida glabrata , in which the micafungin sessile MIC values were significantly lower ( P <0.001). These observations were confirmed by assessing biofilm structure by scanning electron microscopy after antifungal treatment. Conclusions: Our study showed that the high in vitro activity of SCY-078 against invasive Candida isolates in both sessile and planktonic forms is comparable to that of micafungin.
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Ibrexafungerp displays activity against biofilms formed by different Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. auris.
“Regarding its anti-biofilm activity, somewhat unsurprisingly since it shares the same target with echinocandins, ibrexafungerp has been shown to display activity against biofilms formed by different Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. glabrata [44], and most recently C. auris [45].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [44]
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- Authors
- Marcos-Zambrano, L. J., Gómez-Perosanz, M., Escribano, P., Bouza, E., & Guinea, J.
- Affiliations
- Hospital General Universitario Gregorio Marañón (ES)
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Guinea, Jesús
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-04-26
- Volume
- 72
- Issue
- 7
- Pages
- 1969-1976
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2586701728
- Cited by
- 44
- References
- 29
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 2 · 2019: 7 · 2018: 2 · 2017: 2
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Antimicrobial Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- micafungin, fluconazole, Candida, fungemia, biofilm, planktonic cells, Candida parapsilosis, Candida glabrata, antifungal susceptibility, invasive candidiasis
- MeSH terms
- Micafungin, Antifungal Agents, Candida, Candida albicans, Candidiasis, Glucosyltransferases, Glycosides, Humans, Microbial Sensitivity Tests, Triterpenes, Biofilms, Candida glabrata, Echinocandins, Lipopeptides, Candidiasis, Invasive
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