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Cited by 167Food composition and propertiesLipoproteins and Cardiovascular HealthNatural Products and Biological Research

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Psyllium-Enriched Cereals Lower Blood Total Cholesterol and LDL Cholesterol, but Not HDL Cholesterol, in Hypercholesterolemic Adults: Results of a Meta-Analysis

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Olson, Beth H., Anderson, Sallee M., Becker, Mark P., Anderson, James W., Hunninghake, Donald B., Jenkins, David J.A., LaRosa, John C., Rippe, James M., Roberts, David C.K., Stoy, Diane B., Summerbell, Carolyn D., Truswell, A. Stewart, Wolever, Thomas M.S., Morris, Diane H., Fulgoni, Victor L.·1997·The Journal of Nutrition
DOI 10.1093/jn/127.10.1973
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Abstract

We conducted a meta-analysis to determine the effect of consumption of psyllium-enriched cereal products on blood total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) levels and to estimate the magnitude of the effect among 404 adults with mild to moderate hypercholesterolemia (TC of 5.17-7.8 mmol/L) who consumed a low fat diet. Studies of psyllium cereals were identified by a computerized search of MEDLINE and Current Contents and by contacting United States-based food companies involved in psyllium research. Published and unpublished studies were reviewed by one author and considered eligible for inclusion in the meta-analysis if they were conducted in humans, were randomized, controlled experiments, and included a control group that ate cereal providing </=3 g soluble fiber/d. Eight published and four unpublished studies, conducted in four countries, met the criteria. Analysis of a linear model was performed, controlling for sex and age. Female subjects were divided into two groups to provide a rough estimate of the effect of menopausal status (premenopausal = <50 y, postmenopausal = >/=50 y) on blood lipids. The meta-analysis showed that subjects who consumed a psyllium cereal had lower TC and LDL-C concentrations [differences of 0.31 mmol/L (5%) and 0.35 mmol/L (9%), respectively] than subjects who ate a control cereal; HDL-C concentrations were unaffected in subjects eating psyllium cereal. There was no effect of sex, age or menopausal status on blood lipids. Results indicate that consuming a psyllium-enriched cereal as part of a low fat diet improves the blood lipid profile of hypercholesterolemic adults over that which can be achieved with a low fat diet alone.

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  1. 1993, J. Am. Med. Assoc., 269, 3015, 10.1001/jama.1993.03500230097036 · DOI

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Metadata

Authors
Olson, B. H., Anderson, S. M., Becker, M. P., Anderson, J. W., Hunninghake, D. B., Jenkins, D. J. A., LaRosa, J. C., Rippe, J. M., Roberts, D. C. K., Stoy, D. B., Summerbell, C. D., Truswell, A. S., Wolever, T. M. S., Morris, D. H., & Fulgoni, V. L.
Affiliations
  • Kellogg's (United States) (US)
  • University of Michigan (US)
  • United States Department of Veterans Affairs (US)
  • University of Minnesota (US)
  • St. Michael's Hospital (CA)
  • George Washington University (US)
  • University of Massachusetts Chan Medical School (US)
  • University of Newcastle Australia (AU)
  • St Bartholomew's Hospital (GB)
  • The University of Sydney (AU)
Corresponding author
Olson, Beth H.
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
1997-10
Volume
127
Issue
10
Pages
1973-1980
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/127.10.1973
OpenAlex
W2171480330
Cited by
167
References
53
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 4 · 2012: 5
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
Keywords
psyllium, hypercholesterolemia, total cholesterol, LDL cholesterol, HDL cholesterol, lipid profile, soluble dietary fiber, low-fat diet, menopausal status, sex differences
MeSH terms
Adult, Edible Grain, Female, Humans, Hypercholesterolemia, Cholesterol, HDL, Cholesterol, LDL, Menopause, Psyllium

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