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Psyllium-Enriched Cereals Lower Blood Total Cholesterol and LDL Cholesterol, but Not HDL Cholesterol, in Hypercholesterolemic Adults: Results of a Meta-Analysis
Open accessAbstract
We conducted a meta-analysis to determine the effect of consumption of psyllium-enriched cereal products on blood total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) levels and to estimate the magnitude of the effect among 404 adults with mild to moderate hypercholesterolemia (TC of 5.17-7.8 mmol/L) who consumed a low fat diet. Studies of psyllium cereals were identified by a computerized search of MEDLINE and Current Contents and by contacting United States-based food companies involved in psyllium research. Published and unpublished studies were reviewed by one author and considered eligible for inclusion in the meta-analysis if they were conducted in humans, were randomized, controlled experiments, and included a control group that ate cereal providing </=3 g soluble fiber/d. Eight published and four unpublished studies, conducted in four countries, met the criteria. Analysis of a linear model was performed, controlling for sex and age. Female subjects were divided into two groups to provide a rough estimate of the effect of menopausal status (premenopausal = <50 y, postmenopausal = >/=50 y) on blood lipids. The meta-analysis showed that subjects who consumed a psyllium cereal had lower TC and LDL-C concentrations [differences of 0.31 mmol/L (5%) and 0.35 mmol/L (9%), respectively] than subjects who ate a control cereal; HDL-C concentrations were unaffected in subjects eating psyllium cereal. There was no effect of sex, age or menopausal status on blood lipids. Results indicate that consuming a psyllium-enriched cereal as part of a low fat diet improves the blood lipid profile of hypercholesterolemic adults over that which can be achieved with a low fat diet alone.
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“Controlled feeding trials of the portfolio dietary pattern demonstrated that each of the components had a low-density lipoprotein cholesterol (LDL-C) lowering effect of 5-10% [14][15][16][17][18] and that the effect was additive when combined as part of this dietary pattern.[8][9][10][11][12][13]”
From Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials (2018) · cites this paper as [14]
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“These data provide confirmation that the LDL-C lowering effect of 5-10% [14][15][16][17][18] of each of the 4 core food components can be considered additive, [8][9][10][11][12][13]”
From Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials (2018) · cites this paper as [14]
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Self-citationMcRorie, J. W., & McKeown, N. M. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.09.021 · Cited by 602
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Metadata
- Authors
- Olson, B. H., Anderson, S. M., Becker, M. P., Anderson, J. W., Hunninghake, D. B., Jenkins, D. J. A., LaRosa, J. C., Rippe, J. M., Roberts, D. C. K., Stoy, D. B., Summerbell, C. D., Truswell, A. S., Wolever, T. M. S., Morris, D. H., & Fulgoni, V. L.
- Affiliations
- Kellogg's (United States) (US)
- University of Michigan (US)
- United States Department of Veterans Affairs (US)
- University of Minnesota (US)
- St. Michael's Hospital (CA)
- George Washington University (US)
- University of Massachusetts Chan Medical School (US)
- University of Newcastle Australia (AU)
- St Bartholomew's Hospital (GB)
- The University of Sydney (AU)
- Corresponding author
- Olson, Beth H.
- ORCID
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 127
- Issue
- 10
- Pages
- 1973-1980
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2171480330
- Cited by
- 167
- References
- 53
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 4 · 2012: 5
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Keywords
- psyllium, hypercholesterolemia, total cholesterol, LDL cholesterol, HDL cholesterol, lipid profile, soluble dietary fiber, low-fat diet, menopausal status, sex differences
- MeSH terms
- Adult, Edible Grain, Female, Humans, Hypercholesterolemia, Cholesterol, HDL, Cholesterol, LDL, Menopause, Psyllium
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