The Role of Leucine in the Regulation of Protein Metabolism

ISSN exercise & sports nutrition review update: research & recommendations

Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945

A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly

Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923

The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption

van Vliet, S., Burd, N. A., & van Loon, L. J. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.204305 · Cited by 651

Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient: An Endocrine Society Clinical Practice Guideline

Heber, D., Greenway, F. L., Kaplan, L. M., Livingston, E., Salvador, J., & Still, C. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2128 · Cited by 521

ISSN exercise & sport nutrition review: research & recommendations

Kreider, R. B., Wilborn, C. D., Taylor, L., Campbell, B., Almada, A. L., Collins, R., Cooke, M., Earnest, C. P., Greenwood, M., Kalman, D. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-7 · Cited by 428

Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal health

Millward, D. J., Layman, D. K., Tomé, D., & Schaafsma, G. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1576s · Cited by 359

Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review

Wilson, G. J., Wilson, J. M., & Manninen, A. H. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-1 · Cited by 306

Efficacy of Whey Protein Supplementation on Resistance Exercise–Induced Changes in Lean Mass, Muscle Strength, and Physical Function in Mobility-Limited Older Adults

Chalé, A., Cloutier, G. J., Hau, C., Phillips, E. M., Dallal, G. E., & Fielding, R. A. (2013) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gls221 · Cited by 208

Excess Leucine Intake Enhances Muscle Anabolic Signaling but Not Net Protein Anabolism in Young Men and Women

Glynn, E. L., Fry, C. S., Drummond, M. J., Timmerman, K. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2010) · The Journal of Nutrition · doi:10.3945/jn.110.127647 · Cited by 194

The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance

Joy, J. M., Lowery, R. P., Wilson, J. M., Purpura, M., De Souza, E. O., Wilson, S. M., Kalman, D. S., Dudeck, J. E., & Jäger, R. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-86 · Cited by 179

Minced beef is more rapidly digested and absorbed than beef steak, resulting in greater postprandial protein retention in older men

Pennings, B., Groen, B. B., van Dijk, J.-W., de Lange, A., Kiskini, A., Kuklinski, M., Senden, J. M., & van Loon, L. J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.051201 · Cited by 167

Differences in Muscle Protein Synthesis and Anabolic Signaling in the Postabsorptive State and in Response to Food in 65–80 Year Old Men and Women

Smith, G. I., Atherton, P., Villareal, D. T., Frimel, T. N., Rankin, D., Rennie, M. J., & Mittendorfer, B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001875 · Cited by 168

Branched-Chain Amino Acid Supplementation Before Squat Exercise and Delayed-Onset Muscle Soreness

Shimomura, Y., Inaguma, A., Watanabe, S., Yamamoto, Y., Muramatsu, Y., Bajotto, G., Sato, J., Shimomura, N., Kobayashi, H., & Mawatari, K. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.3.236 · Cited by 166

Dietary Guidelines should reflect new understandings about adult protein needs

Layman, D. K. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-12 · Cited by 146

Contemporary Issues in Protein Requirements and Consumption for Resistance Trained Athletes

Wilson, J., & Wilson, G. J. (2006) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-3-1-7 · Cited by 75

Muscle protein turnover in the elderly and its potential contribution to the development of sarcopenia

Murton, A. J. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115000130 · Cited by 66

No Significant Differences in Muscle Growth and Strength Development When Consuming Soy and Whey Protein Supplements Matched for Leucine Following a 12 Week Resistance Training Program in Men and Women: A Randomized Trial

Lynch, H. M., Buman, M. P., Dickinson, J. M., Ransdell, L. B., Johnston, C. S., & Wharton, C. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113871 · Cited by 56

Whey Protein Improves Marathon-Induced Injury and Exercise Performance in Elite Track Runners

Huang, W.-C., Chang, Y.-C., Chen, Y.-M., Hsu, Y.-J., Huang, C.-C., Kan, N.-W., & Chen, S.-S. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.19584 · Cited by 54

Amount Rather than Animal vs Plant Protein Intake Is Associated with Skeletal Muscle Mass in Community-Dwelling Middle-Aged and Older Chinese Adults: Results from the Guangzhou Nutrition and Health Study

Li, C.-Y., Fang, A.-P., Ma, W.-J., Wu, S.-L., Li, C.-L., Chen, Y.-M., & Zhu, H.-L. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.03.010 · Cited by 44

A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during a marathon

Areces, F., Salinero, J. J., Abian-Vicen, J., González-Millán, C., Gallo-Salazar, C., Ruiz-Vicente, D., Lara, B., & Del Coso, J. (2014) · Amino Acids · doi:10.1007/s00726-014-1677-3 · Cited by 42

A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors

Arazi, H., Taati, B., & Suzuki, K. (2018) · Antioxidants · doi:10.3390/antiox7100148 · Cited by 40

Effects of low-dose milk protein supplementation following low-to-moderate intensity exercise training on muscle mass in healthy older adults: a randomized placebo-controlled trial

Nakayama, K., Saito, Y., Sanbongi, C., Murata, K., & Urashima, T. (2021) · European Journal of Nutrition · doi:10.1007/s00394-020-02302-4 · Cited by 27

The Vitality, Independence, and Vigor in the Elderly 2 Study (VIVE2): Design and methods

Kirn, D. R., Koochek, A., Reid, K. F., von Berens, Å., Travison, T. G., Folta, S., Sacheck, J., Nelson, M., Liu, C., Phillips, E., et al. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.06.001 · Cited by 25

Whey Protein Supplementation Combined with Exercise on Muscle Protein Synthesis and the AKT/mTOR Pathway in Healthy Adults: A Systematic Review and Meta-Analysis

Ji, X., Ye, X., Ji, S., Zhang, S., Wang, Y., Zhou, Z., Xiang, D., & Luo, B. (2025) · Nutrients · doi:10.3390/nu17162579 · Cited by 12

Comparison of the effect of soya protein and whey protein on body composition: A meta-analysis of randomised clinical trials

Piri Damaghi, M., Mirzababaei, A., Moradi, S., Daneshzad, E., Tavakoli, A., Clark, C. C. T., & Mirzaei, K. (2022) · British Journal of Nutrition · doi:10.1017/s0007114521001550 · Cited by 11

HMB Supplementation and Resistance Training: Current Overview on Inflammation, Oxidative Stress and Cardiovascular Risk Factors

Arazi, H., Taati, B., & Suzuki, K. (2021) · Recent Research Advances in Biology Vol. 5 · doi:10.9734/bpi/rrab/v5/7486d · Cited by 6