Efficacy of Whey Protein Supplementation on Resistance Exercise–Induced Changes in Lean Mass, Muscle Strength, and Physical Function in Mobility-Limited Older Adults
Open accessAbstract
BACKGROUND: Whey protein supplementation may augment resistance exercise-induced increases in muscle strength and mass. Further studies are required to determine whether this effect extends to mobility-limited older adults. The objectives of the study were to compare the effects of whey protein concentrate (WPC) supplementation to an isocaloric control on changes in whole-body lean mass, mid-thigh muscle cross-sectional area, muscle strength, and stair-climbing performance in older mobility-limited adults in response to 6 months of resistance training (RT). METHODS: Eighty mobility-limited adults aged 70-85 years were randomized to receive WPC (40g/day) or an isocaloric control for 6 months. All participants also completed a progressive high-intensity RT intervention. Sample sizes were calculated based on the primary outcome of change in whole-body lean mass to give 80% power for a 0.05-level, two-sided test. RESULTS: Lean mass increased 1.3% and 0.6% in the WPC and control groups, respectively. Muscle cross-sectional area was increased 4.6% and 2.9% in the WPC and control groups, respectively, and muscle strength increased 16%-50% in WPC and control groups. Stair-climbing performance also improved in both groups. However, there were no statistically significant differences in the change in any of these variables between groups. CONCLUSIONS: These data suggest that WPC supplementation at this dose does not offer additional benefit to the effects of RT in mobility-limited older adults.
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A trial in mobility-limited older adults comparing resistance training with whey protein supplementation or an isocaloric diet over 6 months found no statistically different changes in lean body mass, muscle cross-sectional area, muscle strength, or stair-climbing.
“Yet another trial compared resistance training in mobility-limited older adults in subgroups who received either whey protein supplementation or an isocaloric diet over 6 months; no statistically different changes were seen in lean body mass, muscle cross-sectional area, muscle strength, PROT-AGE recommendations for exercise and protein intake for older adults Endurance exercise is recommended at”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [146]
Cites
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · see citing works
Tang, J. E., Moore, D. R., Kujbida, G. W., Tarnopolsky, M. A., & Phillips, S. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00076.2009 · Cited by 998 · see citing works
Moore, D. R., Robinson, M. J., Fry, J. L., Tang, J. E., Glover, E. I., Wilkinson, S. B., Prior, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26401 · Cited by 973 · see citing works
High-Velocity Resistance Training Increases Skeletal Muscle Peak Power in Older Women
Fielding, R. A., LeBrasseur, N. K., Cuoco, A., Bean, J., Mizer, K., & Singh, M. A. F. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50159.x · Cited by 446 · see citing works
Self-citationMuscle power of the ankle flexors predicts functional performance in community-dwelling older women.
Suzuki, T., Bean, J. F., & Fielding, R. A. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49232.x · Cited by 343 · see citing works
Self-citationKukuljan, S., Nowson, C. A., Sanders, K., & Daly, R. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00392.2009 · Cited by 154 · see citing works
Reid, K. F., Callahan, D. M., Carabello, R. J., Phillips, E. M., Frontera, W. R., & Fielding, R. A. (2008) · Aging Clinical and Experimental Research · doi:10.1007/bf03324865 · Cited by 153 · see citing works
Self-citation
Flagged first, then by citations
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Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · see citing works
Cruz-Jentoft, A. J., Landi, F., Schneider, S. M., Zuniga, C., Arai, H., Boirie, Y., Chen, L.-K., Fielding, R. A., Martin, F. C., Michel, J.-P., et al. (2014) · Age and Ageing · doi:10.1093/ageing/afu115 · Cited by 1,963 · see citing works
Self-citationBauer, J. M., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., McMurdo, M. E. T., Mets, T., Seal, C., Wijers, S. L., et al. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.021 · Cited by 670 · see citing works
Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.
the IOF-ESCEO Sarcopenia Working Group, Beaudart, C., Dawson, A., Shaw, S. C., Harvey, N. C., Kanis, J. A., Binkley, N., Reginster, J. Y., Chapurlat, R., Chan, D. C., et al. (2017) · Osteoporosis International · doi:10.1007/s00198-017-3980-9 · Cited by 602 · see citing works
Does nutrition play a role in the prevention and management of sarcopenia?
Robinson, S. M., Reginster, J. Y., Rizzoli, R., Shaw, S. C., Kanis, J. A., Bautmans, I., Bischoff-Ferrari, H., Bruyère, O., Cesari, M., Dawson-Hughes, B., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.016 · Cited by 491 · see citing works
Self-citationNutritional considerations for healthy aging and reduction in age-related chronic disease
Shlisky, J., Bloom, D. E., Beaudreault, A. R., Tucker, K. L., Keller, H. H., Freund-Levi, Y., Fielding, R. A., Cheng, F. W., Jensen, G. L., Wu, D., et al. (2017) · Advances in Nutrition · doi:10.3945/an.116.013474 · Cited by 462 · see citing works
Self-citationUnderstanding the gut microbiota and sarcopenia: a systematic review
Liu, C., Cheung, W., Li, J., Chow, S. K., Yu, J., Wong, S. H., Ip, M., Sung, J. J. Y., & Wong, R. M. Y. (2021) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12784 · Cited by 363 · see citing works
Liao, C.-D., Tsauo, J.-Y., Wu, Y.-T., Cheng, C.-P., Chen, H.-C., Huang, Y.-C., Chen, H.-C., & Liou, T.-H. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.143594 · Cited by 317 · see citing works
The Future Prevalence of Sarcopenia in Europe: A Claim for Public Health Action
Ethgen, O., Beaudart, C., Buckinx, F., Bruyère, O., & Reginster, J. Y. (2017) · Calcified Tissue International · doi:10.1007/s00223-016-0220-9 · Cited by 280 · see citing works
Nunes, E. A., Colenso‐Semple, L., McKellar, S. R., Yau, T., Ali, M. U., Fitzpatrick‐Lewis, D., Sherifali, D., Gaudichon, C., Tomé, D., Atherton, P. J., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12922 · Cited by 280 · see citing works
“Eleven studies tested the effect of protein intervention on physical function in parallel to RE training.(39,50,52,56,58,72,75,76,94,100,104)”
BackgroundProtein Requirements and Recommendations for Older People: A Review
Nowson, C., & O'Connell, S. (2015) · Nutrients · doi:10.3390/nu7085311 · Cited by 243 · see citing works
Protein intake and muscle function in older adults
Deer, R. R., & Volpi, E. (2015) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000162 · Cited by 206 · see citing works
Finger, D., Goltz, F. R., Umpierre, D., Meyer, E., Rosa, L. H. T., & Schneider, C. D. (2015) · Sports Medicine · doi:10.1007/s40279-014-0269-4 · Cited by 185 · see citing works
Bukhari, S. S. I., Phillips, B. E., Wilkinson, D. J., Limb, M. C., Rankin, D., Mitchell, W. K., Kobayashi, H., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00481.2014 · Cited by 162 · see citing works
Komar, B., Schwingshackl, L., & Hoffmann, G. (2015) · The Journal of nutrition, health and aging · doi:10.1007/s12603-014-0559-4 · Cited by 161 · see citing works
ten Haaf, D. S. M., Nuijten, M. A. H., Maessen, M. F. H., Horstman, A. M. H., Eijsvogels, T. M. H., & Hopman, M. T. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy192 · Cited by 152 · see citing works
Englund, D. A., Kirn, D. R., Koochek, A., Zhu, H., Travison, T. G., Reid, K. F., von Berens, Å., Melin, M., Cederholm, T., Gustafsson, T., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx141 · Cited by 151 · see citing works
Self-citationXu, Z.-R., Tan, Z.-J., Zhang, Q., Gui, Q.-F., & Yang, Y.-M. (2015) · British Journal of Nutrition · doi:10.1017/s0007114514002475 · Cited by 136 · see citing works
Strategic creatine supplementation and resistance training in healthy older adults
Candow, D. G., Vogt, E., Johannsmeyer, S., Forbes, S. C., & Farthing, J. P. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0498 · Cited by 121 · see citing works
Dawson, J. K., Dorff, T. B., Todd Schroeder, E., Lane, C. J., Gross, M. E., & Dieli-Conwright, C. M. (2018) · BMC Cancer · doi:10.1186/s12885-018-4306-9 · Cited by 112 · see citing works
Thomas, D. K., Quinn, M. A., Saunders, D. H., & Greig, C. A. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.07.002 · Cited by 108 · see citing works
Wirth, J., Hillesheim, E., & Brennan, L. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa049 · Cited by 87 · see citing works
Effect of creatine supplementation and drop-set resistance training in untrained aging adults
Johannsmeyer, S., Candow, D. G., Brahms, C. M., Michel, D., & Zello, G. A. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.08.005 · Cited by 59 · see citing works
Fielding, R. A., Travison, T. G., Kirn, D. R., Koochek, A., Reid, K. F., von Berens, Å., Zhu, H., Folta, S. C., Sacheck, J. M., Nelson, M. E., et al. (2017) · The Journal of nutrition, health and aging · doi:10.1007/s12603-017-0936-x · Cited by 58 · see citing works
Self-citationFast digestive proteins and sarcopenia of aging
Boirie, Y., & Guillet, C. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000427 · Cited by 56 · see citing works
Hidayat, K., Chen, G.-C., Wang, Y., Zhang, Z., Dai, X., Szeto, I. M. Y., & Qin, L.-Q. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-017-0899-y · Cited by 52 · see citing works
Hernández-Lepe, M. A., Miranda-Gil, M. I., Valbuena-Gregorio, E., & Olivas-Aguirre, F. J. (2023) · Nutrients · doi:10.3390/nu15081998 · Cited by 46 · see citing works
Alternative dietary protein sources to support healthy and active skeletal muscle aging
van der Heijden, I., Monteyne, A. J., Stephens, F. B., & Wall, B. T. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuac049 · Cited by 45 · see citing works
Liao, C.-D., Huang, S.-W., Chen, H.-C., Huang, M.-H., Liou, T.-H., & Lin, C.-L. (2024) · Nutrients · doi:10.3390/nu16070941 · Cited by 45 · see citing works
Nakayama, K., Saito, Y., Sanbongi, C., Murata, K., & Urashima, T. (2021) · European Journal of Nutrition · doi:10.1007/s00394-020-02302-4 · Cited by 27 · see citing works
The Vitality, Independence, and Vigor in the Elderly 2 Study (VIVE2): Design and methods
Kirn, D. R., Koochek, A., Reid, K. F., von Berens, Å., Travison, T. G., Folta, S., Sacheck, J., Nelson, M., Liu, C., Phillips, E., et al. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.06.001 · Cited by 25 · see citing works
Self-citationGray, M., Powers, M., Boyd, L., & Garver, K. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-0929-6 · Cited by 20 · see citing works
Gade, J., Pedersen, R. J., & Beck, A. M. (2018) · Rehabilitation Process and Outcome · doi:10.1177/1179572718765760 · Cited by 16 · see citing works
Al-Rawhani, A. H., Adznam, S. N., Abu Zaid, Z., Md. Yusop, N. B., M. Sallehuddin, H., & Alshawsh, M. A. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.08.033 · Cited by 13 · see citing works
Batsis, J. A., Petersen, C. L., Cook, S. B., Al-Nimr, R. I., Driesse, T., Pidgeon, D., & Fielding, R. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.07.006 · Cited by 3 · see citing works
Self-citation
- Authors
- Chalé, A., Cloutier, G. J., Hau, C., Phillips, E. M., Dallal, G. E., & Fielding, R. A.
- Affiliations
- Tufts University (US)
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10-31
- Volume
- 68
- Issue
- 6
- Pages
- 682-690
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC3708517
- OpenAlex
- W2111002841
- Cited by
- 208
- References
- 7
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 14 · 2021: 21 · 2020: 24 · 2019: 16 · 2018: 24 · 2017: 20 · 2016: 17 · 2015: 23 · 2014: 15 · 2013: 9 · 2012: 1
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Repository (Kingston University London) (submittedVersion)
- Funders
- U.S. Department of Agriculture (No. 58-1950-0-014, #58–1950-0-014, 1P30AG031679)
- National Institutes of Health (5p30ag031679-15, 5t32dk007651-19)
- National Institute on Aging (1 P30 AG031679)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK007651)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- whey protein concentrate, protein supplementation, resistance training, older adults, lean body mass, muscle strength, muscle cross-sectional area, physical function, sarcopenia
- MeSH terms
- Whey Proteins, Aged, Aged, 80 and over, Aging, Body Composition, Energy Intake, Double-Blind Method, Female, Humans, Male, Milk Proteins, Physical Endurance, Absorptiometry, Photon, Case-Control Studies, Range of Motion, Articular, Treatment Outcome, Muscle, Skeletal, Dietary Supplements, Muscle Stretching Exercises, Muscle Strength
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