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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Decreased Cancer Risk After Iron Reduction in Patients With Peripheral Arterial Disease: Results From a Randomized Trial

Zacharski, L. R., Chow, B. K., Howes, P. S., Shamayeva, G., Baron, J. A., Dalman, R. L., Malenka, D. J., Ozaki, C. K., Lavori, P. W.·2008·JNCI Journal of the National Cancer Institute
DOI 10.1093/jnci/djn209
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Abstract

Background Excess iron has been implicated in cancer risk through increased iron-catalyzed free radical-mediated oxidative stress. Methods A multicenter randomized, controlled, single-blinded clinical trial (VA Cooperative Study #410) tested the hypothesis that reducing iron stores by phlebotomy would influence vascular outcomes in patients with peripheral arterial disease. Patients without a visceral malignancy in the last 5 years (n = 1277) were randomly assigned to control (n = 641) or iron reduction (n = 636). Occurrence of new visceral malignancy and cause-specific mortality data were collected prospectively. Cancer and mortality outcomes in the two arms were compared using intent-to-treat analysis with a Cox proportional hazards regression model. Statistical tests were two-sided. Results Patients were followed up for an average of 4.5 years. Ferritin levels were similar in both groups at baseline but were lower in iron reduction patients than control patients across all 6-month visits (mean = 79.7 ng/mL, 95% confidence interval [CI] = 73.8 to 85.5 ng/mL vs 122.5 ng/mL, 95% CI = 115.5 to 129.5 ng/mL; P Conclusions Iron reduction was associated with lower cancer risk and mortality. Further studies are needed to define the role of body iron in cancer risk.

Overview

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Crossref · 10.1093/jnci/djn209

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4 of 4 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 4 references

Research works printed but not linked: 31

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Metadata

Authors
Zacharski, L. R., Chow, B. K., Howes, P. S., Shamayeva, G., Baron, J. A., Dalman, R. L., Malenka, D. J., Ozaki, C. K., & Lavori, P. W.
Venue
JNCI Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Published
2008-07-08
Volume
100
Issue
14
Pages
996-1002
ISSN
  • 0027-8874
  • 1460-2105
DOI
10.1093/jnci/djn209
Cited by
230
References
4
Language
en

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