Perfluorooctanoate and Perfluorooctanesulfonate Plasma Levels and Risk of Cancer in the General Danish Population
Abstract
Perfluorooctanoate and perfluorooctanesulfonate are used in many industrial products and have been widely detected in human blood. Both chemicals are associated with tumor development in animal studies, but data on carcinogenic potential in humans are sparse. We investigated the association between plasma levels of perfluorooctanoate and perfluorooctanesulfonate and cancer risk within a prospective Danish cohort of participants with no previous cancer diagnosis at enrollment. From enrollment, between December 1, 1993, and May 31, 1997, and through July 1, 2006, we identified 713 participants with prostate cancer, 332 with bladder cancer, 128 with pancreatic cancer, and 67 with liver cancer in the entire cohort and we selected a comparison subcohort of 772. Plasma concentrations of perfluorooctanoate and perfluorooctanesulfonate were measured in each participant by use of high-pressure liquid chromatography coupled to tandem mass spectrometry. We found no clear differences in incidence rate ratios for these cancers in relation to plasma concentrations of perfluorooctanoate or perfluorooctanesulfonate. A 30%-40% increase in risk estimates for prostate cancer was observed for the three upper quartiles of perfluorooctanesulfonate concentration compared with the lowest quartile (eg, for the lowest vs the fourth quartile, incidence rate ratio = 1.38, 95% confidence interval = 0.99 to 1.93). Plasma concentrations of perfluorooctanoate and perfluorooctanesulfonate in the general Danish population appear not to be associated with risk of prostate, bladder, pancreatic, or liver cancer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Only studies by Eriksen et al. and Hardell et al. showed a statistically significant association between PFC concentration and prostate cancer.
“Only studies made by Eriksen et al. and Hardell et al. showed statistical significant association between PFC concentration and prostate cancer [17, 20].”
From Overview of emerging contaminants and associated human health effects (2015) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Proportional hazards tests and diagnostics based on weighted residuals
GRAMBSCH, P. M., & THERNEAU, T. M. (1994) · Biometrika · doi:10.1093/biomet/81.3.515 · Cited by 5,885 · see citing works
Estimation of Average Concentration in the Presence of Nondetectable Values
Hornung, R. W., & Reed, L. D. (1990) · Applied Occupational and Environmental Hygiene · doi:10.1080/1047322x.1990.10389587 · Cited by 3,495 · see citing works
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750 · see citing works
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049 · see citing works
Dose-Response and Trend Analysis in Epidemiology
Greenland, S. (1995) · Epidemiology · doi:10.1097/00001648-199507000-00005 · Cited by 1,086 · see citing works
Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
Kannan, K., Corsolini, S., Falandysz, J., Fillmann, G., Kumar, K. S., Loganathan, B. G., Mohd, M. A., Olivero, J., Wouwe, N. V., Yang, J. H., et al. (2004) · Environmental Science & Technology · doi:10.1021/es0493446 · Cited by 1,056 · see citing works
The toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742 · see citing works
Analysis of Case-Cohort Designs
Barlow, W. E., Ichikawa, L., Rosner, D., & Izumi, S. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00102-x · Cited by 682 · see citing works
Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
Fei, C., McLaughlin, J. K., Tarone, R. E., & Olsen, J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10506 · Cited by 628 · see citing works
Self-citationTjønneland, A. M., Olsen, A., Boll, K., Stripp, C., Christensen, J., Engholm, G., & Overvad, K. (2007) · Scandinavian Journal of Public Health · doi:10.1080/14034940601047986 · Cited by 595 · see citing works
Self-citationRobust Variance Estimation for the Case-Cohort Design
Barlow, W. E. (1994) · Biometrics · doi:10.2307/2533444 · Cited by 542 · see citing works
Olsen, G. W., Burris, J. M., Burlew, M., & Mandel, J. H. (2003) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000052958.59271.10 · Cited by 362 · see citing works
Emmett, E. A., Shofer, F. S., Zhang, H., Freeman, D. W., Desai, C. S., & Shaw, L. M. J. (2006) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000232486.07658.74 · Cited by 357 · see citing works
Ehresman, D. J., Froehlich, J. W., Olsen, G. W., Chang, S., & Butenhoff, J. L. (2006) · Environmental Research · doi:10.1016/j.envres.2006.06.008 · Cited by 344 · see citing works
Perfluorochemicals in Pooled Serum Samples from United States Residents in 2001 and 2002
Calafat, A. M., Kuklenyik, Z., Caudill, S. P., Reidy, J. A., & Needham, L. L. (2006) · Environmental Science & Technology · doi:10.1021/es0517973 · Cited by 216 · see citing works
Butenhoff, J. L., Olsen, G. W., & Pfahles-Hutchens, A. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9060 · Cited by 199 · see citing works
Mortality Among Employees of a Perfluorooctanoic Acid Production Plant
Gilliland, F. D., & Mandel, J. S. (1993) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-199309000-00020 · Cited by 183 · see citing works
Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility
Alexander, B. H., Olsen, G. W., Burris, J. M., Mandel, J. H., & Mandel, J. S. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.10.722 · Cited by 179 · see citing works
Perfluorinated chemicals in selected residents of the American continent
Calafat, A. M., Needham, L. L., Kuklenyik, Z., Reidy, J. A., Tully, J. S., Aguilar-Villalobos, M., & Naeher, L. P. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.08.028 · Cited by 162 · see citing works
Midasch, O., Schettgen, T., & Angerer, J. (2006) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2006.06.002 · Cited by 112 · see citing works
Storm, H. H. (1991) · PubMed · Cited by 106 · see citing works
Bladder Cancer in Perfluorooctanesulfonyl Fluoride Manufacturing Workers
Alexander, B. H., & Olsen, G. W. (2007) · Annals of Epidemiology · doi:10.1016/j.annepidem.2007.01.036 · Cited by 104 · see citing works
Rothman, K. (2002) · Medical Entomology and Zoology · Cited by 36 · see citing works
Peroxisomal Enzymes and 8‐Hydroxydeoxyguanosine in Rat Liver Treated with Perfluorooctanoic Acid
Abdellatif, A. G., Al-tonsy, A. H., Awad, M., Roberfroid, M., & Khan, M. N. (2003) · Disease Markers · doi:10.1155/2003/135859 · Cited by 23 · see citing works
Rothman, K. J., Huybrechts, K. F., & Murray, E. J. (2024) · doi:10.1093/oso/9780197751541.001.0001 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 8
- Olsen GW , Burris JM , Ehresman DJ , et al . Half-life of serum elimination of perfl uorooc- tanesulfonate, perfl uorohexanesulfonate, and perfl uorooctanoate in retired fl uorochemical production workers . Environ Health Perspect . 2007 ; 115 ( 9 ): 1298 -1305 .
- Kennedy GL Jr , Butenhoff JL , Olsen GW , et al . The toxicology of perfl uorooctanoate . Crit Rev Toxicol . 2004 ; 34 ( 4 ): 351 -384 .
- Alexander BH , Olsen GW , Burris JM , Mandel JH , Mandel JS . Mortality of employees of a perfl uorooctanesulphonyl fl uoride manufac- turing facility . Occup Environ Med . 2003 ; 60 ( 10 ): 722 -729 .
- Alexander BH , Olsen GW . Bladder cancer in perfl uorooctanesulfonyl fl uoride manufactur- ing workers . Ann Epidemiol . 2007 ; 17 ( 6 ): 471 -478 .
- Gilliland FD , Mandel JS . Mortality among employees of a perfl uorooctanoic acid produc- tion plant . J Occup Med . 1993 ; 35 ( 9 ): 950 -954 .
- Ehresman DJ , Froehlich JW , Olsen GW , Chang SC , Butenhoff JL . Comparison of human whole blood, plasma, and serum matri- ces for the determination of perfl uorooctane- sulfonate (PFOS), perfl uorooctanoate (PFOA), and other fl uorochemicals . Environ Res. 2007 ; 103 ( 2 ): 176 -184 .
- Hornung RW , Reed LD . Estimation of aver- age concentration in the presence of nonde- tectable values . Appl Occup Environ Hyg . 1990 ; 5 ( 1 ): 46 -51 .
- Grambsch PM , Therneau TM . Proportional tests and diagnostics based on weighted resid- uals . Biometrika . 1994 ; 81 ( 3 ): 515 -526 .
Cited by
Sorted by citations
Sunderland, E. M., Hu, X. C., Dassuncao, C., Tokranov, A. K., Wagner, C. C., & Allen, J. G. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0094-1 · Cited by 2,786 · see citing works
Barry, V., Winquist, A. G., & Steenland, K. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306615 · Cited by 781 · see citing works
Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)
Steenland, K., Fletcher, T., & Savitz, D. A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901827 · Cited by 660 · see citing works
Post, G. B., Cohn, P. D., & Cooper, K. R. (2012) · Environmental Research · doi:10.1016/j.envres.2012.03.007 · Cited by 639 · see citing works
Podder, A., Sadmani, A. H. M. A., Reinhart, D., Chang, N.-B., & Goel, R. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126361 · Cited by 623 · see citing works
(CONTAM), E. P. O. C. I. T. F. C., Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B. J., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5194 · Cited by 519 · see citing works
PFAS and cancer, a scoping review of the epidemiologic evidence
Steenland, K., & Winquist, A. G. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110690 · Cited by 431 · see citing works
Vieira, V. M., Hoffman, K., Shin, H., Weinberg, J., Webster, T. F., & Fletcher, T. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205829 · Cited by 355 · see citing works
Perfluoroalkylated substances (PFAS) affect oxidative stress biomarkers in vitro
Wielsøe, M., Long, M., Ghisari, M., & Bonefeld‐Jørgensen, E. C. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.10.014 · Cited by 286 · see citing works
Zhang, L., Ren, X.-M., & Guo, L.-H. (2013) · Environmental Science & Technology · doi:10.1021/es4026722 · Cited by 267 · see citing works
Highly Defective UiO-66 Materials for the Adsorptive Removal of Perfluorooctanesulfonate
Clark, C. A., Heck, K. N., Powell, C. D., & Wong, M. S. (2019) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.8b05572 · Cited by 237 · see citing works
Overview of emerging contaminants and associated human health effects
Lei, M., Zhang, L., Lei, J., Zong, L., Li, J., Wu, Z., & Wang, Z. (2015) · BioMed Research International · doi:10.1155/2015/404796 · Cited by 231 · see citing works
Perfluorinated compounds: Emerging POPs with potential immunotoxicity
Corsini, E., Luebke, R. W., Germolec, D. R., & DeWitt, J. C. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.01.038 · Cited by 207 · see citing works
Eriksen, K. T., Raaschou‐Nielsen, O., Sørensen, M., Roursgaard, M., Loft, S. H., & Möller, P. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.04.024 · Cited by 192 · see citing works
Self-citationChang, E. T., Adami, H.-O., Boffetta, P., Cole, P., Starr, T. B., & Mandel, J. S. (2014) · Critical Reviews in Toxicology · doi:10.3109/10408444.2014.905767 · Cited by 180 · see citing works
Nisio, A. D., Šabović, I., Valente, U., Tescari, S., Rocca, M. S., Guidolin, D., Dall’Acqua, S., Acquasaliente, L., Pozzi, N., Plebani, M., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01855 · Cited by 166 · see citing works
Eriksen, K. T., Raaschou‐Nielsen, O., McLaughlin, J. K., Lipworth, L., Tjønneland, A. M., Overvad, K., & Sørensen, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056969 · Cited by 160 · see citing works
Self-citationReview: Evolution of evidence on PFOA and health following the assessments of the C8 Science Panel.
Steenland, K., Fletcher, T., Stein, C. R., Bartell, S., Darrow, L., López-Espinosa, M.-J., Ryan, P., & Savitz, D. (2020) · Environment International · doi:10.1016/j.envint.2020.106125 · Cited by 139 · see citing works
Ammonium Perfluorooctanoate Production and Occupational Mortality
Lundin, J. I., Alexander, B. H., Olsen, G. W., & Church, T. R. (2009) · Epidemiology · doi:10.1097/ede.0b013e3181b5f395 · Cited by 156 · see citing works
Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances
Temkin, A. M., Hocevar, B. A., Andrews, D. Q., Naidenko, O. V., & Kamendulis, L. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051668 · Cited by 153 · see citing works
Butenhoff, J. L., Chang, S., Olsen, G. W., & Thomford, P. J. (2012) · Toxicology · doi:10.1016/j.tox.2012.01.003 · Cited by 144 · see citing works
A cohort incidence study of workers exposed to perfluorooctanoic acid (PFOA)
Steenland, K., Zhao, L., & Winquist, A. G. (2015) · Occupational and Environmental Medicine · doi:10.1136/oemed-2014-102364 · Cited by 133 · see citing works
Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort
Goodrich, J. A., Walker, D. I., Lin, X., Wang, H., Lim, T., McConnell, R., Conti, D. V., Chatzi, L., & Setiawan, V. W. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100550 · Cited by 132 · see citing works
Singh, K., Kumar, N., Yadav, A. K., Singh, R. D., & Kumar, K. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145064 · Cited by 131 · see citing works
Elcombe, C. R., Elcombe, B. M., Foster, J. R., Chang, S., Ehresman, D. J., & Butenhoff, J. L. (2012) · Toxicology · doi:10.1016/j.tox.2011.12.014 · Cited by 128 · see citing works
Major contaminants of emerging concern in soils: a perspective on potential health risks
Maddela, N. R., Ramakrishnan, B., Kakarla, D., Venkateswarlu, K., & Megharaj, M. (2022) · RSC Advances · doi:10.1039/d1ra09072k · Cited by 122 · see citing works
Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer
Boyd, R. I., Ahmad, S., Singh, R., Fazal, Z., Prins, G. S., Madak‐Erdogan, Z., Irudayaraj, J., & Spinella, M. J. (2022) · Cancers · doi:10.3390/cancers14122919 · Cited by 112 · see citing works
Lau, C. S. (2012) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-7643-8340-4_3 · Cited by 103 · see citing works
The impact of PFOS on health in the general population: a review
Saikat, S., Kreis, I., Davies, B., Bridgman, S., & Kamanyire, R. (2013) · Environ. Sci.: Processes Impacts · doi:10.1039/c2em30698k · Cited by 101 · see citing works
Li, H., Hammarstrand, S., Midberg, B., Xu, Y., Li, Y., Olsson, D. S., Fletcher, T., Jakobsson, K., & Andersson, E. M. (2021) · Environmental Research · doi:10.1016/j.envres.2021.112217 · Cited by 100 · see citing works
Mortality and cancer incidence in ammonium perfluorooctanoate production workers
Raleigh, K. K., Alexander, B. H., Olsen, G. W., Ramachandran, G., Morey, S. Z., Church, T. R., Logan, P. W., Scott, P., & Allen, E. M. (2014) · Occupational and Environmental Medicine · doi:10.1136/oemed-2014-102109 · Cited by 97 · see citing works
Klaunig, J. E., Shinohara, M., Iwai, H., Chengelis, C. P., Kirkpatrick, J. B., Wang, Z., & Bruner, R. H. (2014) · Toxicologic Pathology · doi:10.1177/0192623314530532 · Cited by 87 · see citing works
Florentin, A., Deblonde, T., Diguio, N., Hautemanière, A., & Hartemann, P. (2011) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2011.05.010 · Cited by 84 · see citing works
Case–control study on perfluorinated alkyl acids (PFAAs) and the risk of prostate cancer
Hardell, E., Kärrman, A., van Bavel, B., Bao, J., Carlberg, M., & Hardell, L. (2014) · Environment International · doi:10.1016/j.envint.2013.10.005 · Cited by 80 · see citing works
Winquist, A., Hodge, J. M., Diver, W. R., Rodriguez, J. L., Troeschel, A. N., Daniel, J., & Teras, L. R. (2023) · Environmental Health Perspectives · doi:10.1289/ehp13174 · Cited by 75 · see citing works
Determinants of Plasma PFOA and PFOS Levels Among 652 Danish Men
Eriksen, K. T., Sørensen, M., McLaughlin, J. K., Tjønneland, A. M., Overvad, K., & Raaschou‐Nielsen, O. (2010) · Environmental Science & Technology · doi:10.1021/es100626h · Cited by 72 · see citing works
Self-citationPerfluorooctanoic acid exposure triggers oxidative stress in the mouse pancreas
Kamendulis, L. M., Wu, Q., Sandusky, G. E., & Hocevar, B. A. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.07.015 · Cited by 73 · see citing works
Butenhoff, J. L., Kennedy, G. L., Chang, S., & Olsen, G. W. (2012) · Toxicology · doi:10.1016/j.tox.2012.04.001 · Cited by 72 · see citing works
Developing innovative treatment technologies for PFAS-containing wastes
Berg, C. E., Crone, B. C., Gullett, B. K., Higuchi, M., Krause, M. J., Lemieux, P., Martin, T. M., Shields, E. P., Struble, E., Thoma, E. D., et al. (2021) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2021.2000903 · Cited by 66 · see citing works
Tachachartvanich, P., Singam, E. R. A., Durkin, K. A., Furlow, J. D., Smith, M. T., & Merrill, M. A. L. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128243 · Cited by 61 · see citing works
Yeung, L. W. Y., Guruge, K. S., Taniyasu, S., Yamashita, N., Angus, P., & Herath, C. B. (2013) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2013.06.006 · Cited by 61 · see citing works
Xu, X., Li, Y., Vo, H. N. P., Shukla, P. R., Ge, L., & Zhao, C. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.157222 · Cited by 61 · see citing works
Risk of Cancer in a Community Exposed to Per- and Poly-Fluoroalkyl Substances
Messmer, M. F., Salloway, J. C., Shara, N. M., Locwin, B., Harvey, M. W., & Traviss, N. (2022) · Environmental Health Insights · doi:10.1177/11786302221076707 · Cited by 57 · see citing works
Impact of perfluorochemicals on human health and reproduction: a male’s perspective
Foresta, C., Tescari, S., & Nisio, A. D. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0790-z · Cited by 57 · see citing works
Winquist, A. G., Lally, C. A., Shin, H., & Steenland, K. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1206450 · Cited by 54 · see citing works
Imir, O. B., Kaminsky, A. Z., Zuo, Q., Liu, Y.-J., Singh, R., Spinella, M. J., Irudayaraj, J., Hu, W., Prins, G. S., & Madak‐Erdogan, Z. (2021) · Nutrients · doi:10.3390/nu13113902 · Cited by 53 · see citing works
Innes, K. E., Wimsatt, J., Frisbee, S. J., & DUCATMAN, A. M. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-45 · Cited by 50 · see citing works
Ogunbiyi, O. D., Ajiboye, T. O., Omotola, E. O., Oladoye, P. O., Olanrewaju, C. A., & Quinete, N. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121705 · Cited by 44 · see citing works
Suman, T. Y., & Kwak, I. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137249 · Cited by 48 · see citing works
Cancer Risk Among Tetrafluoroethylene Synthesis and Polymerization Workers
Consonni, D., Straíf, K., Symons, J. M., Tomenson, J. A., van Amelsvoort, L. G. P. M., Sleeuwenhoek, A., Cherrie, J. W., Bonetti, P., Colombo, I., Farrar, D. G., et al. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws588 · Cited by 46 · see citing works
Detection and removal of poly and perfluoroalkyl polluting substances for sustainable environment
Pilli, S., Pandey, A. K., Pandey, V., Pandey, K., Muddam, T., Thirunagari, B. K., Thota, S. T., Varjani, S., & Tyagi, R. D. (2021) · Journal of Environmental Management · doi:10.1016/j.jenvman.2021.113336 · Cited by 46 · see citing works
Wang, Y., Li, X., Zheng, Z., Shi, Y., & Cai, Y. (2021) · Environment International · doi:10.1016/j.envint.2021.106820 · Cited by 44 · see citing works
Hull, S. D., Deen, L., Petersen, K. U., Jensen, T. K., Hammer, P., Wils, R. S., Frankel, H. N., Ostrowski, S. R., & Tøttenborg, S. S. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117036 · Cited by 42 · see citing works
Estrogen receptor beta mediates hepatotoxicity induced by perfluorooctane sulfonate in mouse
Xu, C. Y., Jiang, Z., Liu, Q., Liu, H., & Gu, A. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-8943-3 · Cited by 42 · see citing works
Clark, K. L., George, J. W., Hua, G., & Davis, J. S. (2022) · Reproductive Toxicology · doi:10.1016/j.reprotox.2022.03.011 · Cited by 41 · see citing works
Per- and polyfluoroalkyl substances target and alter human prostate stem-progenitor cells
Hu, W., Lu, R., Hu, D., Imir, O. B., Zuo, Q., Moline, D., Afradiasbagharani, P., Liu, L., Lowe, S., Birch, L. A., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114902 · Cited by 42 · see citing works
Hai, Z., Li, J., Li, H., Hu, G., & Li, H. (2014) · Journal of Food Science · doi:10.1111/1750-3841.12470 · Cited by 40 · see citing works
Seyyedsalehi, M. S., & Boffetta, P. (2023) · La Medicina del Lavoro · doi:10.23749/mdl.v114i5.15065 · Cited by 77 · see citing works
Li, H., Yang, M., Yang, J. G., Seery, S., Ma, C., Liu, Y., Zhang, X., Li, A., & Guo, H. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139411 · Cited by 38 · see citing works
Arrieta-Cortes, R., Farías, P., Hoyo‐Vadillo, C., & Kleiche‐Dray, M. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.11.021 · Cited by 36 · see citing works
Deprouw, C., Courties, A., Fini, J., Clerget-Froidevaux, M.-S., DEMENEIX, B. A., Berenbaum, F., Sellam, J., & Louati, K. (2022) · RMD Open · doi:10.1136/rmdopen-2021-001983 · Cited by 36 · see citing works
Cholesterol-like Condensing Effect of Perfluoroalkyl Substances on a Phospholipid Bilayer
Shen, Z., Ge, J., Ye, H., Tang, S., & Li, Y. (2020) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c00980 · Cited by 35 · see citing works
Rhee, J., Barry, K. H., Huang, W., Sampson, J. N., Hofmann, J. N., Silverman, D. T., Calafat, A. M., Botelho, J. C., Kato, K., Purdue, M. P., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115718 · Cited by 35 · see citing works
Comito, R., Porru, E., & Violante, F. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.140433 · Cited by 20 · see citing works
Research and Regulatory Advancements on Remediation and Degradation of Fluorinated Polymer Compounds
Olsavsky, N. J., Kearns, V. M., Beckman, C. P., Sheehan, P. L., Burpo, F. J., Bahaghighat, H. D., & Nagelli, E. A. (2020) · Applied Sciences · doi:10.3390/app10196921 · Cited by 37 · see citing works
Law, H. D., Armstrong, B. K., D’Este, C. A., Hosking, R., Smurthwaite, K. S., Trevenar, S. M., Lucas, R. M., Lazarevic, N., Kirk, M., & Korda, R. (2022) · Cancer Epidemiology · doi:10.1016/j.canep.2022.102296 · Cited by 35 · see citing works
PFOS-induced apoptosis through mitochondrion-dependent pathway in human–hamster hybrid cells
Wang, X., Zhao, G., Liang, J., Jiang, J., Chen, N., Yu, J., Wang, Q., Xu, A., Chen, S., & Wu, L. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.04.004 · Cited by 32 · see citing works
Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
Porta, M. S., Gasull, M., Pumarega, J. A., Kiviranta, H., Rantakokko, P., Raaschou‐Nielsen, O., Bergdahl, I. A., Sandanger, T. M., Agudo, A., Rylander, C., et al. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyab115 · Cited by 32 · see citing works
Self-citationTaylor, C. M., Ellingsen, T. A., Breadmore, M. C., & Kilah, N. L. (2021) · Chemical Communications · doi:10.1039/d1cc04903h · Cited by 31 · see citing works
Zhu, Y., Yang, D., Duan, X., Zhang, Y., Chen, D., Gong, Z., & Liu, C. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110962 · Cited by 31 · see citing works
Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
Montes‐Grajales, D., Bernardes, G. J. L., & Olivero-Verbel, J. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00342 · Cited by 23 · see citing works
Per- and polyfluorinated substances in the Nordic Countries
Posner, S., Roos, S., Poulsen, P. B., Jörundsdóttir, H. Ó., Gunnlaugsdóttir, H., Trier, X., Jensen, A. A., Katsogiannis, A. A., Herzke, D., Bonefeld‐Jørgensen, E. C., et al. (2013) · doi:10.6027/tn2013-542 · Cited by 28 · see citing works
York, R. G., Kennedy, G., Olsen, G., & Butenhoff, J. (2010) · Toxicology · doi:10.1016/j.tox.2010.03.005 · Cited by 30 · see citing works
Anik, A. H., Basir, M. S., Sultan, M. B., Alam, M., Rahman, M. M., & Tareq, S. M. (2025) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2025.117554 · Cited by 24 · see citing works
Hardisty, J. F., Willson, G. A., Brown, W. R., McConnell, E. E., Frame, S. R., Gaylor, D. W., Kennedy, G. L., & Butenhoff, J. L. (2010) · Drug and Chemical Toxicology · doi:10.3109/01480541003667610 · Cited by 23 · see citing works
Tardiff, R. G., Carson, M. L., Sweeney, L. M., Kirman, C. R., Tan, Y., Andersen, M. E., Bevan, C. D., & Gargas, M. L. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.07.016 · Cited by 23 · see citing works
The Latest Sensor Detection Methods for per- and Polyfluoroalkyl Substances
Zhang, M., Zhao, Y., Bui, B., Tang, L., Xue, J., Chen, M., & Chen, W. (2024) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2023.2299233 · Cited by 21 · see citing works
Per- and polyfluoroalkyl substances in new firefighter turnout gear textiles
Maizel, A. C., Thompson, A. L., Tighe, M., Veras, S. E., Rodowa, A. E., Falkenstein‐Smith, R., Benner, B. A., Hoffman, K. M., Donnelly, M. K., Hernandez, O., et al. (2023) · doi:10.6028/nist.tn.2248 · Cited by 21 · see citing works
Wang, T., Yang, J., Han, Y., & Wāng, Y. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173085 · Cited by 22 · see citing works
Halsne, R., Tandberg, J. I., Lobert, V. H., Østby, G. C., Thoen, E., Ropstad, E., & Verhaegen, S. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.08.004 · Cited by 20 · see citing works
Ferretti, F., Barbarossa, A., & Bardhi, A. (2026) · Environmental Science and Pollution Research · doi:10.1007/s11356-026-37412-9 · Cited by 21 · see citing works
Exposure to perfluorooctanoic acid leads to promotion of pancreatic cancer
Kamendulis, L. M., Hocevar, J. M., Stephens, M., Sandusky, G. E., & Hocevar, B. A. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac005 · Cited by 20 · see citing works
Oh, J., Kim, E., & Nam, T. (2018) · Marine Drugs · doi:10.3390/md16020044 · Cited by 18 · see citing works
Buławska, N., Sosnowska, A., Kowalska, D., Stepnik, M., & Puzyn, T. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.143967 · Cited by 17 · see citing works
Choi, J., Kim, J.-Y., & Lee, H. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191811318 · Cited by 15 · see citing works
Environmental risk factors for liver cancer
McGlynn, K. A., Watling, C. Z., Hernandez, B. Y., & Groopman, J. D. (2025) · Hepatology · doi:10.1097/hep.0000000000001463 · Cited by 17 · see citing works
Troeschel, A. N., Teras, L. R., Hodge, J. M., Rodriguez, J., Wang, Y., Daniel, J. H., Diver, W. R., & Winquist, A. G. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119560 · Cited by 16 · see citing works
Butenhoff, J. L., Olsen, G. W., & Chang, S. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.02.017 · Cited by 15 · see citing works
Per‐ and Polyfluoroalkyl Substances (PFAS) in Drinking Water
Kougias, D. G., Killius, A., Collins, J., Russman, E., & Maddaloni, M. A. (2024) · Wiley eBooks · doi:10.1002/9781119742975.ch7 · Cited by 15 · see citing works
Kerketta, A., & Sahoo, P. K. (2022) · Groundwater for Sustainable Development · doi:10.1016/j.gsd.2022.100803 · Cited by 14 · see citing works
Abdullah, M., Adhikary, S., Bhattacharya, S., Hazra, S., Ganguly, A., Nanda, S., & Rajak, P. (2024) · Toxicology · doi:10.1016/j.tox.2024.153981 · Cited by 14 · see citing works
Cholesterol-like effects of a fluorotelomer alcohol incorporated in phospholipid membranes
Jbeily, M., Bärenwald, R., Kreßler, J., Saalwächter, K., & Ferreira, T. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20511-0 · Cited by 14 · see citing works
Advanced Nanoformulations for Detection and Removal of Poly- and Perfluoroalkyl Substances (PFAS)
Kumar, J., & Narayan, M. (2025) · Pollutants · doi:10.3390/pollutants5020010 · Cited by 14 · see citing works
Tanghal, R. B., Beglarian, E., Stem, A. D., Aung, M. T., Alderete, T. L., DUCATMAN, A. M., Vasiliou, V., McConnell, R., Conti, D. V., & Chatzi, L. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c05535 · Cited by 13 · see citing works
Zhang, S., Kappil, E. M., Zheng, T., Boffetta, P., & Seyyedsalehi, M. S. (2024) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000935 · Cited by 12 · see citing works
Rae, J. M. C., Frame, S. R., Kennedy, G. L., Butenhoff, J. L., & Chang, S. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.04.005 · Cited by 11 · see citing works
Khalil, N., Lee, M., & Steenland, K. (2015) · Molecular and integrative toxicology · doi:10.1007/978-3-319-15518-0_13 · Cited by 11 · see citing works
Hossini, H., Massahi, T., Parnoon, K., & Nouri, M. (2025) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2025.2538224 · Cited by 10 · see citing works
Porta, M. S., Pumarega, J. A., Amaral, A. F. S., Genkinger, J. M., Camargo, J., Mucci, L. A., Alguacil, J., Gasull, M., Zhang, X., Morales, E., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109781 · Cited by 10 · see citing works
Bartell, S. M., Purdue, M. P., Rhee, J., Nøst, T. H., Rusiecki, J. A., & Steenland, K. (2024) · Environment International · doi:10.1016/j.envint.2024.109056 · Cited by 9 · see citing works
- Authors
- Eriksen, K. T., Sorensen, M., McLaughlin, J. K., Lipworth, L., Tjonneland, A., Overvad, K., & Raaschou-Nielsen, O.
- Affiliations
- Aarhus University Hospital (DK)
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-07
- Volume
- 101
- Issue
- 8
- Pages
- 605-609
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2098197528
- Cited by
- 150
- References
- 25
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 17 · 2023: 12 · 2022: 14 · 2021: 11 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 7
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- 3M
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Keywords
- perfluorooctanoic acid, PFOS, perfluorinated compounds, plasma concentration, cancer risk, prostate cancer, bladder cancer, pancreatic cancer, liver cancer, prospective cohort, carcinogenicity, biomarkers of exposure
- MeSH terms
- Aged, Analysis of Variance, Urinary Bladder Neoplasms, Caprylates, Chromatography, High Pressure Liquid, Denmark, Environmental Pollutants, Female, Fluorocarbons, Humans, Liver Neoplasms, Male, Middle Aged, Neoplasms, Pancreatic Neoplasms, Prospective Studies, Prostatic Neoplasms, Risk Factors, Cohort Studies, Incidence, Odds Ratio, Alkanesulfonic Acids, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
