Cited by 13,288Gene expression and cancer classificationBioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Open access

Edgar, R.·2002·Nucleic Acids Research

DOI 10.1093/nar/30.1.207PMC PMC99122

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Abstract

The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. GEO provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-throughput gene expression and genomic hybridization experiments. GEO is not intended to replace in house gene expression databases that benefit from coherent data sets, and which are constructed to facilitate a particular analytic method, but rather complement these by acting as a tertiary, central data distribution hub. The three central data entities of GEO are platforms, samples and series, and were designed with gene expression and genomic hybridization experiments in mind. A platform is, essentially, a list of probes that define what set of molecules may be detected. A sample describes the set of molecules that are being probed and references a single platform used to generate its molecular abundance data. A series organizes samples into the meaningful data sets which make up an experiment. The GEO repository is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo.

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Authors: Edgar, R.
Affiliations: National Institutes of Health (US)
Corresponding author: Edgar, R.
ORCID: Edgar, R.
Venue: Nucleic Acids Research
Publisher: Oxford University Press (OUP)
Published: 2002-01-01
Volume: 30
Issue: 1
Pages: 207-210
ISSN: 0305-1048 (ISSN-L)
1362-4962
DOI: 10.1093/nar/30.1.207
PMC: PMC99122
OpenAlex: W2020541351
Cited by: 13,288
References: 8
Citations by year: 2026: 616 · 2025: 746 · 2024: 960 · 2023: 1010 · 2022: 991 · 2021: 1102 · 2020: 991 · 2019: 820 · 2018: 689 · 2017: 668 · 2016: 658 · 2015: 649 · 2014: 638 · 2013: 570 · 2012: 510
FWCI: 27.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Nucleic Acids Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: Gene Expression Omnibus, gene expression data, genomic hybridization, microarray data, public data repositories, data submission, data storage and retrieval, biological specimen
MeSH terms: Animals, Communication, Database Management Systems, Forecasting, Humans, National Library of Medicine (U.S.), United States, Information Storage and Retrieval, Genome, Internet, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Databases, Genetic

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