The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes
Open accessAbstract
MicroRNAs (miRNAs) are a class of small regulatory RNAs that are thought to be involved in diverse biological processes by regulating gene expression. Numerous miRNAs have been identified in various species, and many more miRNAs remain to be detected. Generally, hundreds of mRNAs have been predicted to be potential targets of one miRNA, so it is a great challenge to identify the genuine miRNA targets. Here, we generated the cell lines depleted of Drosha protein and screened dozens of transcripts (including Cyclin D1) regulated potentially by miRNA-mediated RNA silencing pathway. On the basis of miRNA expressing library, we established a miRNA targets reverse screening method by using luciferase reporter assay. By this method, we found that the expression of Cyclin D1 (CCND1) was regulated by miR-16 family directly, and miR-16 induced G1 arrest in A549 cells partially by CCND1. Furthermore, several other cell cycle genes were revealed to be regulated by miR-16 family, including Cyclin D3 (CCND3), Cyclin E1 (CCNE1) and CDK6. Taken together, our data suggests that miR-16 family triggers an accumulation of cells in G0/G1 by silencing multiple cell cycle genes simultaneously, rather than the individual target.
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Cited by
The role and mechanisms of action of microRNAs in cancer drug resistance
Si, W., Shen, J., Zheng, H., & Fan, W. (2019) · Clinical Epigenetics · doi:10.1186/s13148-018-0587-8 · Cited by 668
Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA
Cazalla, D., Yario, T., & Steitz, J. A. (2010) · Science · doi:10.1126/science.1187197 · Cited by 483
miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes
Porrello, E. R., Johnson, B. A., Aurora, A. B., Simpson, E., Nam, Y.-J., Matkovich, S. J., Dorn, G. W., van Rooij, E., & Olson, E. N. (2011) · Circulation Research · doi:10.1161/circresaha.111.248880 · Cited by 444
Visone, R., & Croce, C. M. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080794 · Cited by 422
Bandi, N., Zbinden, S., Gugger, M., Arnold, M., Kocher, V., Hasan, L., Kappeler, A., Brunner, T., & Vassella, E. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4277 · Cited by 386
Metadata
- Authors
- Liu, Q., Fu, H., Sun, F., Zhang, H., Tie, Y., Zhu, J., Xing, R., Sun, Z., & Zheng, X.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-13
- Volume
- 36
- Issue
- 16
- Pages
- 5391-5404
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2036923470
- Cited by
- 477
- References
- 47
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, Q., Fu, H., Sun, F., Zhang, H., Tie, Y., Zhu, J., Xing, R., Sun, Z., & Zheng, X. (2008). miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Research. https://doi.org/10.1093/nar/gkn522
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