Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: A systematic review and meta-analyses of randomized trials

Suzumura, Erica A; Bersch-Ferreira, Ângela C; Torreglosa, Camila R; da Silva, Jacqueline T; Coqueiro, Audrey Y; Kuntz, Marilyn G F; Chrispim, Pedro P; Weber, Bernardete; Cavalcanti, Alexandre B

doi:10.1093/nutrit/nuz001

Cited by 85Probiotics and Fermented FoodsGut microbiota and healthInfant Nutrition and Health

Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: A systematic review and meta-analyses of randomized trials

Suzumura, Erica A, Bersch-Ferreira, Ângela C, Torreglosa, Camila R, da Silva, Jacqueline T, Coqueiro, Audrey Y, Kuntz, Marilyn G F, Chrispim, Pedro P, Weber, Bernardete +1 more·2019·Nutrition Reviews

DOI 10.1093/nutrit/nuz001

Open this paper in CoChat — free account

Abstract

CONTEXT: Recent evidence suggests that modulation of the gut microbiota may contribute to body weight control. OBJECTIVE: This systematic review aimed to assess the effects of oral supplementation with probiotics or synbiotics on body weight, body mass index (BMI), and waist circumference in overweight and obese adults (BMI ≥ 25 kg/m2). DATA SOURCES: Five electronic databases-PubMed, Embase, Cochrane Library/CENTRAL, LILACS, and Web of Science-were searched from inception to August 2017. No language restrictions were applied. STUDY SELECTION: Randomized and quasi-randomized parallel trials that assessed the effects of oral supplementation with probiotics or synbiotics vs any other intervention but bariatric surgery or fecal transplantation in overweight or obese adults were selected. DATA EXTRACTION: Three teams of 2 authors independently assessed risk of bias and extracted data from the included trials. Data were pooled using inverse-variance random-effects meta-analyses. The quality of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. RESULTS: Nineteen randomized trials (28 publications, 1412 participants) were included. There were no differences in mean body weight change [mean difference (MD), -0.54 kg; 95%CI, -1.09 to 0.01; I2 = 0%; moderate quality of evidence) or mean BMI change (MD, -0.19 kg/m2; 95%CI, -0.43 to 0.04; I2 = 51%; low quality of evidence) between groups who received probiotics or synbiotics and control groups. Oral supplementation with probiotics or synbiotics reduced mean waist circumference compared with control (MD, -0.82 cm; 95%CI, -1.43 to -0.21; I2 = 46%; low quality of evidence). CONCLUSIONS: The findings suggest that oral supplementation with probiotics or synbiotics has a small effect to reduce waist circumference but no effect on body weight or BMI, although the quality of evidence is low to moderate. Therefore, the current evidence is not definitive. Large-scale trials are needed and may help to better inform clinical practice. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration number CRD42018075126.

Integrity signals

Registry

Crossref · 10.1093/nutrit/nuz001

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Systematic reviews show that consuming probiotics causes overweight and obese people to lose weight, but the weight loss and reduction in waist circumference and visceral fat is small.
“Systematic reviews have shown that by consuming probiotics [137,138,139,140], overweight and obese people lose weight, but the weight loss and reduction in waist circumference and visceral fat is small [137,138,139,140].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [138]

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Untitled work
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
Abarca-Gómez, L., Abdeen, Z. A., Hamid, Z. A., Abu-Rmeileh, N. M., Acosta-Cazares, B., Acuin, C., Adams, R. J., Aekplakorn, W., Afsana, K., Aguilar-Salinas, C. A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32129-3 · Cited by 7,482 · see citing works
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions
Tarsilla, M. (2010) · Journal of MultiDisciplinary Evaluation · doi:10.56645/jmde.v6i14.284 · Cited by 5,228 · see citing works
GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)
Guyatt, G. H., Oxman, A. D., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Montori, V., Akl, E. A., Djulbegovic, B., & Falck-Ytter, Y. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.017 · Cited by 2,798 · see citing works
GRADE guidelines 6. Rating the quality of evidence—imprecision
Guyatt, G. H., Oxman, A. D., Kunz, R., Brozek, J., Alonso-Coello, P., Rind, D., Devereaux, P. J., Montori, V. M., Freyschuss, B., Vist, G., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.012 · Cited by 2,693 · see citing works
GRADE guidelines: 7. Rating the quality of evidence—inconsistency
Guyatt, G. H., Oxman, A. D., Kunz, R., Woodcock, J., Brozek, J., Helfand, M., Alonso-Coello, P., Glasziou, P., Jaeschke, R., Akl, E. A., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.03.017 · Cited by 2,320 · see citing works
Investigating and dealing with publication and other biases in meta-analysis
Sterne, J. A. C., Egger, M., & Smith, G. D. (2001) · BMJ · doi:10.1136/bmj.323.7304.101 · Cited by 2,225 · see citing works
GRADE guidelines: 8. Rating the quality of evidence—indirectness
Guyatt, G. H., Oxman, A. D., Kunz, R., Woodcock, J., Brozek, J., Helfand, M., Alonso-Coello, P., Falck-Ytter, Y., Jaeschke, R., Vist, G., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.04.014 · Cited by 1,843 · see citing works
GRADE guidelines: 5. Rating the quality of evidence—publication bias
Guyatt, G. H., Oxman, A. D., Montori, V., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Djulbegovic, B., Atkins, D., Falck-Ytter, Y., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.011 · Cited by 1,819 · see citing works
<i>meta-analysis</i> bias in location and selection of studies
Egger, M., & Smith, G. D. (1998) · BMJ · doi:10.1136/bmj.316.7124.61 · Cited by 1,374 · see citing works
Energy balance and obesity: what are the main drivers?
On behalf of the IARC working group on Energy Balance and Obesity, Romieu, I., Dossus, L., Barquera, S., Blottière, H. M., Franks, P. W., Gunter, M. J., Hwalla, N. C., Hursting, S. D., Leitzmann, M. F., et al. (2017) · Cancer Causes & Control · doi:10.1007/s10552-017-0869-z · Cited by 745 · see citing works
Ten Putative Contributors to the Obesity Epidemic
McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., et al. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372599 · Cited by 710 · see citing works
Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
Kadooka, Y., Sato, M., Imaizumi, K., Ogawa, A., Ikuyama, K., Akai, Y., Okano, M., Kagoshima, M., & Tsuchida, T. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.19 · Cited by 700 · see citing works
Obesity, Diabetes, and Gut Microbiota
Musso, G., Gambino, R., & Cassader, M. (2010) · Diabetes Care · doi:10.2337/dc10-0556 · Cited by 662 · see citing works
The microbiota-gut-brain axis in obesity.
Torres-Fuentes, C., Schellekens, H., Dinan, T., & Cryan, J. (2017) · The Lancet Gastroenterology and Hepatology · doi:10.1016/s2468-1253(17)30147-4 · Cited by 506 · see citing works
Microbiota-gut-brain axis: Modulator of host metabolism and appetite
van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461 · see citing works
Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals
Million, M., Angelakis, E., Paul, M., Armougom, F., Leibovici, L., & Raoult, D. (2012) · Microbial Pathogenesis · doi:10.1016/j.micpath.2012.05.007 · Cited by 431 · see citing works
Effect of <i>Lactobacillus rhamnosus</i> CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women
Sanchez, M., Darimont, C., Drapeau, V., Emady-Azar, S., Lepage, M., Rezzonico, E., Ngom-Bru, C., Berger, B., Philippe, L., Ammon-Zuffrey, C., et al. (2014) · British Journal of Nutrition · doi:10.1017/s0007114513003875 · Cited by 351 · see citing works
Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials
Sáez‐Lara, M. J., Robles-Sánchez, C., Ruiz‐Ojeda, F. J., Plaza‐Díaz, J., & Gil, Á. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060928 · Cited by 331 · see citing works
Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases
Agerholm-Larsen, L., Raben, A., Haulrik, N., Hansen, A., Manders, M., & Astrup, A. V. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600937 · Cited by 319 · see citing works
Synbiotics in Health and Disease
Kolida, S., & Gibson, G. R. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133739 · Cited by 309 · see citing works
Probiotics and health: An evidence-based review
Aureli, P., Capurso, L., Castellazzi, A. M., Clerici, M., Giovannini, M., Morelli, L., Poli, A., Pregliasco, F. E., Salvini, F. M., & Zuccotti, G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.02.006 · Cited by 281 · see citing works
Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: A systematic review and meta-analysis of randomized controlled trials
Borgeraas, H., Johnson, L. K., Skattebu, J., Hertel, J. K., & Hjelmesæth, J. (2018) · Obesity Reviews · doi:10.1111/obr.12626 · Cited by 278 · see citing works
Metabolic effects of L actobacillus reuteri DSM 17938 in people with type 2 diabetes: A randomized controlled trial
Mobini, R., Tremaroli, V., Ståhlman, M., Karlsson, F. H., Levin, M., Ljungberg, M., Sohlin, M. C., Forslund, H. B., Perkins, R., Bäckhed, F., et al. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12861 · Cited by 266 · see citing works
Influence of consumption of probiotics on the plasma lipid profile: A meta-analysis of randomised controlled trials
Guo, Z., Liu, X. M., Zhang, Q. X., Shen, Z., Tian, F., Zhang, H., Sun, Z., Zhang, H. P., & Chen, W. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.04.008 · Cited by 249 · see citing works
Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease
Nabavi, S., Rafraf, M., Somi, M. H., Rad, A. H., & Jafarabadi, M. A. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-8500 · Cited by 235 · see citing works
Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial
Kadooka, Y., Sato, M., Ogawa, A., Miyoshi, M., Uenishi, H., Ogawa, H., Ikuyama, K., Kagoshima, M., & Tsuchida, T. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001037 · Cited by 232 · see citing works
Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients - a randomized double-blind placebo-controlled pilot study
Sharafedtinov, K. K., Plotnikova, O. A., Исмаиловна, А. Р., Sentsova, T. B., Songisepp, E., Štšepetova, J., Smidt, I., & Mikelsaar, M. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-138 · Cited by 226 · see citing works
Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges
Martinez, R. C. R., Bedani, R., & Saad, S. M. I. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003864 · Cited by 208 · see citing works
Probiotic with or without Fiber Controls Body Fat Mass, Associated with Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial
Stenman, L. K., Lehtinen, M. J., Meland, N., Christensen, J. E., Yeung, N., Saarinen, M. T., Courtney, M., Burcelin, R., Lähdeaho, M.-L., Linros, J., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.036 · Cited by 177 · see citing works
Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial
Asemi, Z., Samimi, M., Tabassi, Z., Rad, M. N., Foroushani, A. R., Khorammian, H., & Esmaillzadeh, A. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.189 · Cited by 175 · see citing works
The effects of co-administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: A randomized double-blind controlled clinical trial
Lee, S. J., Bose, S., Seo, J., Chung, W., Lim, C., & Kim, H. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2013.12.006 · Cited by 164 · see citing works
The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double‐blind, randomized trial
Gomes, A. C., de Sousa, R. G. M., Botelho, P. B., Gomes, T. L. N., Prada, P. O., & Mota, J. F. (2016) · Obesity · doi:10.1002/oby.21671 · Cited by 143 · see citing works
Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass: A Systematic Review and Meta-Analysis
John, G. K., Wang, L., Nanavati, J., Twose, C., Singh, R., & Mullin, G. E. (2018) · Genes · doi:10.3390/genes9030167 · Cited by 143 · see citing works
Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals
Sánchez, M., Darimont, C., Panahi, S., Drapeau, V., Marette, A., Taylor, V. H., Doré, J., & Tremblay, A. (2017) · Nutrients · doi:10.3390/nu9030284 · Cited by 138 · see citing works
Effects of probiotic yogurt on fat distribution and gene expression of proinflammatory factors in peripheral blood mononuclear cells in overweight and obese people with or without weight-loss diet
Zarrati, M., Salehi, E., Nourijelyani, K., Mofid, V., Zadeh, M. J. H., Najafi, F., Ghaflati, Z., Bidad, K., Chamari, M., Karimi, M., et al. (2014) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.874937 · Cited by 130 · see citing works
Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trials
Zhang, Q., Wu, Y., & Fei, X. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1181156 · Cited by 122 · see citing works
The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study
Leber, B., Tripolt, N. J., Blattl, D., Eder, M., Wascher, T. C., Pieber, T. R., Stauber, R. E., Sourij, H., Oettl, K., & Stadlbauer, V. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.103 · Cited by 120 · see citing works
Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial
Higashikawa, F., Noda, M., Awaya, T., Danshiitsoodol, N., Matoba, Y., Kumagai, T., & Sugiyama, M. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.17 · Cited by 120 · see citing works
Comparison of the effect of daily consumption of probiotic compared with low-fat conventional yogurt on weight loss in healthy obese women following an energy-restricted diet: a randomized controlled trial
Madjd, A., Taylor, M. A., Mousavi, N., Delavari, A., Malekzadeh, R., Macdonald, I. A., & Farshchi, H. R. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.120170 · Cited by 118 · see citing works
A Randomized Controlled Clinical Trial Investigating the Effect of Synbiotic Administration on Markers of Insulin Metabolism and Lipid Profiles in Overweight Type 2 Diabetic Patients with Coronary Heart Disease
Ebrahimi, M. T., Sharifi, N., Farrokhian, A., Raygan, F., Karamali, F., Razzaghi, R., Taheri, S., & Asemi, Z. (2016) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0042-105441 · Cited by 118 · see citing works
Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial
Minami, J.-I., Kondo, S., Yanagisawa, N., Odamaki, T., Xiao, J., Abe, F., Nakajima, S., Hamamoto, Y., Saitoh, S., & Shimoda, T. (2015) · Journal of Nutritional Science · doi:10.1017/jns.2015.5 · Cited by 112 · see citing works
Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects
Jung, S., Lee, Y. J., Kim, M., Kim, M., Kwak, J. H., Lee, J., Ahn, Y.-T., Jae-Hun, S., & Lee, J. H. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.10.006 · Cited by 77 · see citing works
Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals
Kim, M., Kim, M., Kang, M., Yoo, H. J., Kim, M. S., Ahn, Y.-T., Sim, J.-H., Jee, S. H., & Lee, J. H. (2017) · Food & Function · doi:10.1039/c6fo00993j · Cited by 67 · see citing works
Kefir drink causes a significant yet similar improvement in serum lipid profile, compared with low-fat milk, in a dairy-rich diet in overweight or obese premenopausal women: A randomized controlled trial
Fathi, Y., Ghodrati, N., Zibaeenezhad, M. J., & Faghih, S. (2016) · Journal of clinical lipidology · doi:10.1016/j.jacl.2016.10.016 · Cited by 66 · see citing works
Intestinal removal of free fatty acids from hosts by Lactobacilli for the treatment of obesity
Chung, H., Yu, J. G., Lee, I., Liu, M., Shen, Y., Sharma, S. P., Jamal, M. A. H. M., Yoo, J., Kim, H., & Hong, S. (2015) · FEBS Open Bio · doi:10.1002/2211-5463.12024 · Cited by 65 · see citing works
Lactobacillus acidophilus La5, Bifidobacterium BB12, and Lactobacillus casei DN001 modulate gene expression of subset specific transcription factors and cytokines in peripheral blood mononuclear cells of obese and overweight people
Zarrati, M., Shidfar, F., Nourijelyani, K., Mofid, V., Hosseinzadeh‐Attar, M. J., Bidad, K., Najafi, F., Gheflati, Z., Chamari, M., & Salehi, E. (2013) · BioFactors · doi:10.1002/biof.1128 · Cited by 63 · see citing works
Kefir drink leads to a similar weight loss, compared with milk, in a dairy-rich non-energy-restricted diet in overweight or obese premenopausal women: a randomized controlled trial
Fathi, Y., Faghih, S., Zibaeenezhad, M. J., & Tabatabaei, S. H. R. (2016) · European Journal of Nutrition · doi:10.1007/s00394-015-0846-9 · Cited by 52 · see citing works
A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects
Tovar, J., Nilsson, A. C., Johansson, M., Ekesbo, R. W., Aberg, A.-M., Johansson, U., & Björck, I. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-29 · Cited by 38 · see citing works
Effect of Lactobacillus Rhamnosus CGMCC1.3724 Supplementation on Weight loss and Maintenance in Obese Men and Women
Sánchez, M., Darimont, C., Drapeau, V., et al. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.03.270 · Cited by 32 · see citing works
The effects of symbiotic therapy on anthropometric measures, body composition and blood pressure in patient with metabolic syndrome: a triple blind RCT.
Rabiei, S., Shakerhosseini, R., & Saadat, N. (2015) · PubMed · Cited by 25 · see citing works
The Potential Role of Probiotics or/and Prebiotic on Serum Lipid Profile and Insulin Resistance in Alcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial
Javadi, L., Ghavami, M., Khoshbaten, M., Safaiyan, A., Barzegari, A., & Gargari, B. P. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 19 · see citing works
The Effect of Probiotic and Conventional Yogurt Consumptions on Anthropometric Parameters in Individuals with Non Alcoholic Fatty Liver Disease
Rafraf, M., Nabavi, S. M., Somi, M. H., Rad, A. H., & Jafarabadi, M. A. (2014) · doi:10.18869/acadpub.jbums.16.9.55 · Cited by 6 · see citing works
[Influence of a low-calorie diet with inclusion of probiotic product containing bacterias Lactobacillus plantarum Tensia DSM 21380 on clinical and metabolic characteristics in patients with obesity and arterial hypertension].
KhKh, S., Плотникова, О. А., Alekseeva, R. I., et al. (2012) · PubMed · Cited by 2 · see citing works
Is there a role for probiotics in older people?
Smith, G. D. (2016) · British Journal of Community Nursing · doi:10.12968/bjcn.2016.21.10.501 · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity
Sergeev, I. N., Aljutaily, T., Walton, G., & Huarte, E. (2020) · Nutrients · doi:10.3390/nu12010222 · Cited by 331 · see citing works
European Association for the Study of Obesity position statement on medical nutrition therapy for the management of overweight and obesity in adults developed in collaboration with the European Federation of the Associations of Dietitians
Hassapidou, M., Vlassopoulos, A., Kalliostra, M., Govers, E., Mulrooney, H., Ells, L., Salas, X. R., Muscogiuri, G., Darleska, T. H., Busetto, L., et al. (2023) · Obesity Facts · doi:10.1159/000528083 · Cited by 121 · see citing works
Effects of probiotics on body adiposity and cardiovascular risk markers in individuals with overweight and obesity: A systematic review and meta-analysis of randomized controlled trials
Pontes, K. S. D. S., Guedes, M. R., Cunha, M. R. D., Mattos, S. D. S., Barreto Silva, M. I., Neves, M. F., Marques, B. C. A. A., & Klein, M. R. S. T. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.06.023 · Cited by 86 · see citing works
The impact of gut microbiome-targeted therapy on liver enzymes in patients with nonalcoholic fatty liver disease: an umbrella meta-analysis
Amini-Salehi, E., Hassanipour, S., Keivanlou, M.-H., Shahdkar, M., Orang Goorabzarmakhi, M., Vakilpour, A., Joukar, F., Hashemi, M., Sattari, N., Javid, M., et al. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuad086 · Cited by 42 · see citing works

Introduction to Synbiotics
Singh, K., Mariki, A. F., Singh, P. A., Arora, S., & Bajwa, N. (2024) · Springer eBooks · doi:10.1007/978-981-99-5575-6_1 · Cited by 3 · see citing works
Probiotics and Prebiotics
de Aguilar‐Nascimento, J. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374938-3.00012-8 · Cited by 2 · see citing works
The Future of Synbiotics: Rational Formulation and Design
Quintero, D. F. G., Kok, C. R., & Hutkins, R. W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.919725 · Cited by 94 · see citing works
Synbiotics in Animal Health and Production
Malik, J. K., Prakash, A., Srivastava, A. K., & Gupta, R. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-04624-8_20 · Cited by 29 · see citing works
Therapeutic Potential of Synbiotics in Management of Various Disorders
Singh, L., Kaur, H., & Bhatti, R. (2024) · Springer eBooks · doi:10.1007/978-981-99-5575-6_16 · Cited by 1 · see citing works

Authors: Suzumura, E. A., Bersch-Ferreira, Â. C., Torreglosa, C. R., da Silva, J. T., Coqueiro, A. Y., Kuntz, M. G. F., Chrispim, P. P., Weber, B., & Cavalcanti, A. B.
Affiliations: Research Institute at Hospital do Coração, São Paulo, Brazil
Hospital do Coração (BR)
Universidade de São Paulo (BR)
Instituto Dona Helena de Ensino e Pesquisa, Joinville, Brazil
ORCID: Bersch-Ferreira, Ângela C
Torreglosa, Camila R
Coqueiro, Audrey Y
Chrispim, Pedro P
Weber, Bernardete
Cavalcanti, Alexandre B
Venue: Nutrition Reviews
Publisher: Oxford University Press (OUP)
Published: 2019-03-28
Volume: 77
Issue: 6
Pages: 430-450
ISSN: 0029-6643 (ISSN-L)
1753-4887
DOI: 10.1093/nutrit/nuz001
OpenAlex: W2931546760
Cited by: 85
References: 61
Citations by year: 2026: 11 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 12 · 2021: 19 · 2020: 8 · 2019: 2
FWCI: 0.92
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor, 1 d)
Locations: Nutrition Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Brazilian Ministry of Health
Desenvolvimento Institucional do SUS
Brazilian Public Health System
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, synbiotics, overweight, obesity, body weight, body mass index, waist circumference, gut microbiota, dietary supplementation, weight management
MeSH terms: Administration, Oral, Adult, Aged, Aged, 80 and over, Body Weight, Female, Humans, Male, Middle Aged, Obesity, Body Mass Index, Randomized Controlled Trials as Topic, Probiotics, Overweight, Waist Circumference, Young Adult, Synbiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of oral supplementation with probiotics or synbiotics in overweight and obese adults: A systematic review and meta-analyses of randomized trials

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks