Ascorbic acid dynamics in the seriously ill and injured
Abstract
Background In addition to the known beneficial effects of ascorbic acid on wound healing and the immune response, it is also a potent extracellular antioxidant. Recent work in septic rats suggests that high-dose ascorbic acid total parenteral nutrition (TPN) supplementation may protect cells from free radical injury and improve survival. In this study, we determined ascorbic acid levels in the immediate post-injury/illness period and evaluated the ability of early short-term high levels of ascorbic acid in TPN to normalize plasma levels.Materials and methods Ascorbic acid levels were determined in 12 critically injured patients and 2 patients with severe surgical infections. Each patient received TPN supplemented with increasing doses of ascorbic acid over a 6-day period. Therapeutic responses were determined by plasma and urine measurements using high-pressure liquid chromatography.Results The initial mean +/- SEM baseline plasma ascorbic acid concentration was depressed (0.11 +/- 0.03 mg/dl) and unresponsive following 2 days on 300 mg/day supplementation (0.14 +/- 0.03; P = 1.0) and only approached low normal plasma levels following 2 days on 1000 mg/day (0.32 +/- 0.08; P = 0.36). A significant increase was noted following 2 days on 3000 mg/day (1.2 +/- 0.03; P = 0.005).Conclusion We confirmed extremely low plasma levels of ascorbic acid following trauma and infection. Maximal early repletion of this vitamin requires rapid pool filling early in the post-injury period using supraphysiologic doses for 3 or more days.
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Surgery, trauma, sepsis, and burns cause a decrease in blood vitamin C, and in very serious injuries, the drop can be very pronounced.
“Not surprisingly, surgery, trauma, sepsis, and burns are causing a decrease in blood vitamin C and, in very serious injuries, the drop can be very pronounced [172,173].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [173]
Cites
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870 · see citing works
Diabetes mellitus and free radicals
Wolff, S. P. (1993) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072637 · Cited by 660 · see citing works
New Concepts in the Biology and Biochemistry of Ascorbic Acid
Flier, J. S., Underhill, L. H., & Levine, M. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604033141407 · Cited by 646 · see citing works
Schorah, C., Downing, C. P., Piripitsi, A., Gallivan, L., Al-Hazaa, A., Sanderson, M., & Bodenham, A. R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.5.760 · Cited by 313 · see citing works
Steady-state turnover and body pool of ascorbic acid in man.
Kallner, A., Hartmann, D., & Hornig, D. (1979) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/32.3.530 · Cited by 222 · see citing works
Plasma antioxidant potential in severe sepsis
Cowley, H., Bacon, P., Goode, H. F., Webster, N. R., Jones, J. G., & Menon, D. K. (1996) · Critical Care Medicine · doi:10.1097/00003246-199607000-00019 · Cited by 205 · see citing works
Sauberlich, H. E. (1994) · Annual Review of Nutrition · doi:10.1146/annurev.nu.14.070194.002103 · Cited by 202 · see citing works
Self-citationBiological Hydroxylations and Ascorbic Acid with Special Regard to Collagen Metabolism
Barnes, M. J., & Kodicek, E. H. (1972) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60793-1 · Cited by 131 · see citing works
Waring, A. J., Drake, I. M., Schorah, C. J., White, K. L. M., Lynch, D. A., Axon, A. T. R., & Dixon, M. F. (1996) · Gut · doi:10.1136/gut.38.2.171 · Cited by 115 · see citing works
A Conspectus of Research on Vitamin C Requirements of Man
Irwin, M. I., & Hutchins, B. K. (1976) · Journal of Nutrition · doi:10.1093/jn/106.6.821 · Cited by 88 · see citing works
Kutnink, M. A., Skala, J. H., Sauberlich, H. E., & Omaye, S. T. (1985) · Journal of Liquid Chromatography · doi:10.1080/01483918508067061 · Cited by 80 · see citing works
Self-citationVitamin C and Cellular Immune Functions
Anderson, R., Smit, M. J., Joone, G., & Staden, A. M. V. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb00131.x · Cited by 74 · see citing works
ASCORBIC ACID ECONOMY IN SURGICAL PATIENTS*
Crandon, J. H., Lennihan, R., Mikal, S., & Reif, A. E. (1961) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1961.tb46124.x · Cited by 58 · see citing works
Ascorbic Acid Economy in Surgical Patients as Indicated by Blood Ascorbic Acid Levels
Crandon, J. H., Landau, B. R., Mikal, S., Balmanno, J., Jefferson, M., & Mahoney, N. (1958) · New England Journal of Medicine · doi:10.1056/nejm195801162580301 · Cited by 54 · see citing works
Kähler, W., Kuklinski, B., Rühlmann, C., & Plötz, C. (1993) · PubMed · Cited by 52 · see citing works
Parenteral vitamin requirements during intravenous feeding
Lowry, S. F., Goodgame, J. T., Maher, M. M., & Brennan, M. F. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.12.2149 · Cited by 47 · see citing works
Sauberlich, H. E. (1981) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(18)31073-4 · Cited by 47 · see citing works
Self-citation(1980) · PubMed · Cited by 46 · see citing works
Levenson, S. Μ., Green, R. W., Taylor, F. H. L., Robinson, P., Page, R. C., Johnson, R. E., & Lund, C. C. (1946) · Annals of Surgery · doi:10.1097/00000658-194611000-00003 · Cited by 40 · see citing works
Ascorbic acid and erythorbic acid metabolism in nonpregnant women
Sauberlich, H. E., Kretsch, M. J., Taylor, P. C., Johnson, H., & Skala, J. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1039 · Cited by 38 · see citing works
Self-citationProlonged Skin Allograft Survival in Vitamin C-Deficient Guinea-Pigs
Kalden, J. R., & Guthy, E. (2008) · European Surgical Research · doi:10.1159/000127607 · Cited by 34 · see citing works
Metabolism and function of ascorbic acid and its metabolites.
Bm, T. (1985) · PubMed · Cited by 27 · see citing works
Serum vitamin level maintenance in cancer patients on total parenteral nutrition
Kirkemo, A., BURT, M. E., & Brennan, M. F. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.5.1003 · Cited by 23 · see citing works
Zweiman, B., Schoenwetter, W. F., & Hildreth, E. A. (1966) · PubMed · Cited by 21 · see citing works
Mechanism for the decreased biosynthesis of cartilage proteoglycan in the scorbutic guinea pig
Bird, T. A., Schwartz, N. B., & Peterkofsky, B. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67363-6 · Cited by 21 · see citing works
Treatment Effects of Parenteral Vitamins in Total Parenteral Nutrition Patients
Dempsey, D. T., Mullen, J. L., Rombeau, J. L., Crosby, L. O., Oberlander, J. L., Knox, L., & Melnik, G. (1987) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607187011003229 · Cited by 21 · see citing works
Plasma and urinary ascorbic acid levels in the postoperative period
Shukla, S. P. (1969) · Cellular and Molecular Life Sciences · doi:10.1007/bf01897573 · Cited by 19 · see citing works
The Effect of the Scorbutic State on Tuberculin Hypersensitivity in the Guinea Pig
Zweiman, B., Schoenwetter, W. F., & Hildreth, E. A. (1966) · The Journal of Immunology · doi:10.4049/jimmunol.96.2.296 · Cited by 19 · see citing works
Ascorbic Acid Elimination in Humans after Intravenous Administration
Yung, S., Mayersohn, M., & Robinson, J. B. (1978) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600671052 · Cited by 18 · see citing works
Suppression of Tuberculin Reaction in the Scorbutic Guinea Pig
Mueller, P. S., & Kies, M. W. (1962) · Nature · doi:10.1038/195813a0 · Cited by 16 · see citing works
Zweiman, B., Besdine, R. W., & Hildreth, E. A. (1966) · PubMed · Cited by 11 · see citing works
Ascorbic acid metabolism in postoperative patients.
Ww, C. (1962) · PubMed · Cited by 10 · see citing works
[Passive transfer of tuberculin hypersensitivity].
Oshima, S. (1968) · PubMed · Cited by 5 · see citing works
Urinary ascorbic acid excretion in postoperative patients
Mason, M., Matyk, P. M., & Doolan, S. A. (1971) · The American Journal of Surgery · doi:10.1016/0002-9610(71)90451-x · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock
Marik, P. E., Khangoora, V., Rivera, R., Hooper, M. H., & Catravas, J. (2017) · Chest · doi:10.1016/j.chest.2016.11.036 · Cited by 887 · see citing works
Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615 · see citing works
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553 · see citing works
Carr, A. C., Rosengrave, P. C., Bayer, S., Chambers, S., Mehrtens, J., & Shaw, G. M. (2017) · Critical Care · doi:10.1186/s13054-017-1891-y · Cited by 413 · see citing works
Role of Vitamin C in the Function of the Vascular Endothelium
May, J. M., & Harrison, F. E. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5205 · Cited by 358 · see citing works
Vitamin C: A concentration-function approach yields pharmacology and therapeutic discoveries
Levine, M., Padayatty, S. J., & Espey, M. G. (2011) · Advances in Nutrition · doi:10.3945/an.110.000109 · Cited by 357 · see citing works
Oudemans-van Straaten, H. M., Man, A. M. S.-D., & de Waard, M. C. (2014) · Critical Care · doi:10.1186/s13054-014-0460-x · Cited by 299 · see citing works
Effect of high-dose Ascorbic acid on vasopressor′s requirement in septic shock
Khalili, H., Zabet, M., Mohammadi, M., & Ramezani, M. (2016) · Journal of Research in Pharmacy Practice · doi:10.4103/2279-042x.179569 · Cited by 298 · see citing works
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis
Hemilä, H., & Chalker, E. (2019) · Nutrients · doi:10.3390/nu11040708 · Cited by 263 · see citing works
Carr, A. C., Shaw, G. M., Fowler, A. A., & Natarajan, R. (2015) · Critical Care · doi:10.1186/s13054-015-1131-2 · Cited by 258 · see citing works
Antioxidant supplementation in sepsis and systemic inflammatory response syndrome
Berger, M. M., & Chioléro, R. L. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000279189.81529.c4 · Cited by 207 · see citing works
Antioxidant Vitamins and Trace Elements in Critical Illness
Koekkoek, W. A. C. (., & van Zanten, A. R. H. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616653832 · Cited by 203 · see citing works
Berger, M. M., Soguel, L., Shenkin, A., Revelly, J.-P., Pinget, C., Baines, M., & Chioléro, R. L. (2008) · Critical Care · doi:10.1186/cc6981 · Cited by 202 · see citing works
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Holford, P., Carr, A. C., Jovic, T. H., Ali, S. R., Whitaker, I. S., Marik, P. E., & Smith, A. D. (2020) · Nutrients · doi:10.3390/nu12123760 · Cited by 201 · see citing works
The Emerging Role of Vitamin C as a Treatment for Sepsis
Kashiouris, M. G., L’Heureux, M., Cable, C. A., Fisher, B. J., Leichtle, S. W., & Fowler, A. A. (2020) · Nutrients · doi:10.3390/nu12020292 · Cited by 177 · see citing works
Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium
Wilson, J. X. (2009) · BioFactors · doi:10.1002/biof.7 · Cited by 176 · see citing works
Vitamin C: a wound healing perspective
Moores, J. (2013) · British Journal of Community Nursing · doi:10.12968/bjcn.2013.18.sup12.s6 · Cited by 175 · see citing works
Vitamin C for the treatment of sepsis: The scientific rationale
Marik, P. E. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.04.007 · Cited by 170 · see citing works
Vitamin C Pharmacokinetics in Critically Ill Patients
de Grooth, H., Manubulu-Choo, W.-P., Zandvliet, A. S., de Man, A., Girbes, A. R. J., Swart, E. L., & Straaten, H. M. O. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.02.025 · Cited by 166 · see citing works
Cerullo, G., Negro, M., Parimbelli, M., Pecoraro, M., Perna, S., Liguori, G., Rondanelli, M., Cena, H., & D’Antona, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574029 · Cited by 171 · see citing works
Bench-to-bedside review: Sepsis - from the redox point of view
Andrades, M. É., Morina, A., Spasić, S. D., & Spasojević, I. (2011) · Critical Care · doi:10.1186/cc10334 · Cited by 158 · see citing works
Starke, J., Schneider, H., Alteheld, B., Stehle, P., & Meier, R. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2010.07.021 · Cited by 156 · see citing works
The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19
Carr, A. C., & Rowe, S. (2020) · Nutrients · doi:10.3390/nu12113286 · Cited by 155 · see citing works
Elke, G., Hartl, W. H., Kreymann, K. G., Adolph, M., Felbinger, T. W., Graf, T., de Heer, G., Heller, A. R., Kampa, U., Mayer, K., et al. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.05.002 · Cited by 150 · see citing works
Vollbracht, C., Schneider, B., Leendert, V., Weiß, G., Auerbach, L., & Beuth, J. (2011) · PubMed · Cited by 145 · see citing works
Antioxidant Micronutrients in Major Trauma and Burns: Evidence and Practice
Berger, M. M. (2006) · Nutrition in Clinical Practice · doi:10.1177/0115426506021005438 · Cited by 143 · see citing works
Vitamin C supplementation in the critically ill patient
Berger, M. M., & Oudemans-van Straaten, H. M. (2015) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000148 · Cited by 133 · see citing works
Hemilä, H., & Chalker, E. (2020) · Journal of Intensive Care · doi:10.1186/s40560-020-0432-y · Cited by 130 · see citing works
Vitamin C: should we supplement?
de Man, A., Elbers, P., & Straaten, H. M. O. (2018) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000510 · Cited by 131 · see citing works
Rationale and impact of vitamin C in clinical nutrition
McGregor, G. P., & Biesalski, H. K. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000247478.79779.8f · Cited by 115 · see citing works
Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury
de Man, A., Elbers, P., & Straaten, H. M. O. (2018) · Critical Care · doi:10.1186/s13054-018-1996-y · Cited by 113 · see citing works
Kumar, S., Saxena, J., Srivastava, V. K., Kaushik, S., Singh, H., Abo‐EL‐Sooud, K., Abdel‐Daim, M. M., Jyoti, A., & Saluja, R. (2022) · Vaccines · doi:10.3390/vaccines10101575 · Cited by 121 · see citing works
Impact of High‐Dose Antioxidants on Outcomes in Acutely Injured Patients
Collier, B. R., Giladi, A. M., Dossett, L. A., Dyer, L., Fleming, S. B., & Cotton, B. A. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108319808 · Cited by 108 · see citing works
Soft Tissue Wounds and Principles of Healing
Strecker-McGraw, M. K., Jones, T. R., & Baer, D. G. (2007) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2006.12.002 · Cited by 104 · see citing works
Zang, Q. S., Sadek, H. A., Maass, D. L., Martinez, B., Ma, L., Kilgore, J. A., Williams, N. S., Frantz, D. E., Wigginton, J. G., Nwariaku, F. E., et al. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00203.2011 · Cited by 103 · see citing works
Wani, S. J., Mufti, S. A., Jan, R. A., Shah, S. U., Qadri, S. M., Khan, U. H., Bagdadi, F. S., Mehfooz, N., & Koul, P. A. (2020) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2020.1718200 · Cited by 103 · see citing works
Evaluation of Vitamin C for Adjuvant Sepsis Therapy
Wilson, J. X. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5401 · Cited by 101 · see citing works
Inflammatory Response in Microvascular Endothelium in Sepsis: Role of Oxidants
Cepinskas, G., & Wilson, J. X. (2008) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2008026 · Cited by 101 · see citing works
Oral candidiasis and nutritional deficiencies in elderly hospitalised patients
Paillaud, É., Merlier, I., Dupeyron, C., Scherman, E., Poupon, J., & Bories, P.-N. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041264 · Cited by 99 · see citing works
Peroxidase Activity of Hemoglobin·Haptoglobin Complexes
Kapralov, A., Vlasova, I. I., Feng, W., Maeda, A., Walson, K., Tyurin, V. A., Huang, Z., Aneja, R. K., Carcillo, J., Bayır, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.045567 · Cited by 96 · see citing works
Wu, F. Y., Wilson, J. X., & Tyml, K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.025 · Cited by 96 · see citing works
Water‐Soluble Vitamins in People with Low Glomerular Filtration Rate or On Dialysis: A Review
Clase, C. M., Ki, V., & Holden, R. M. (2013) · Seminars in Dialysis · doi:10.1111/sdi.12099 · Cited by 91 · see citing works
Vitamin C requirement in surgical patients
Fukushima, R., & Yamazaki, E. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833e05bc · Cited by 88 · see citing works
Litwak, J., Cho, N. H., Nguyen, H., Moussavi, K., & Bushell, T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040478 · Cited by 84 · see citing works
Antioxidant therapy in critical care—Is the microcirculation the primary target?
Biesalski, H. K., & McGregor, G. P. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000278598.95294.c5 · Cited by 85 · see citing works
Tyml, K., Li, F., & Wilson, J. X. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000172548.34622.de · Cited by 84 · see citing works
Wang, Y., Lin, H., Lin, B., & Lin, J. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0532-9 · Cited by 83 · see citing works
Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review
Sahoo, D. K., Wong, D. M., Patani, A., Paital, B., Yadav, V. K., Patel, A., & Jergens, A. E. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1348713 · Cited by 87 · see citing works
Menon, V. P., Mohamed, Z. U., Prasannan, P., Moni, M., Edathadathil, F., Prasanna, P., Menon, A., Balachandran, S., Greeshma, C., Sathyapalan, D. T., et al. (2020) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-23517 · Cited by 82 · see citing works
Putzu, A., Daems, A.-M., Lopez-Delgado, J. C., Giordano, V. F., & Landoni, G. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003700 · Cited by 77 · see citing works
Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach
Hill, A., Borosch, S., Benstoem, C., Neubauer, C., Meybohm, P., Langlois, P. L., Adhikari, N. K. J., Heyland, D. K., & Stoppe, C. (2018) · Nutrients · doi:10.3390/nu10080974 · Cited by 74 · see citing works
Vitamin C supplementation in the critically ill: A systematic review and meta-analysis
Zhang, M., & Jativa, D. F. (2018) · SAGE Open Medicine · doi:10.1177/2050312118807615 · Cited by 76 · see citing works
DGEM-Leitlinie: „Klinische Ernährung in der Intensivmedizin“
Elke, G., Hartl, W. H., Kreymann, K. G., Adolph, M., Felbinger, T. W., Graf, T., de Heer, G., Heller, A. R., Kampa, U., Mayer, K., et al. (2018) · Aktuelle Ernährungsmedizin · doi:10.1055/a-0713-8179 · Cited by 76 · see citing works
Vitamin C Requirements in Parenteral Nutrition
Berger, M. M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.012 · Cited by 74 · see citing works
Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury
Spoerke, N. J. (2009) · Archives of Surgery · doi:10.1001/archsurg.2009.154 · Cited by 71 · see citing works
Rosengrave, P., Spencer, E. S., Williman, J. A., Mehrtens, J. E., Morgan, S., Doyle, T., Heyden, K. V. D., Morris, A., Shaw, G. M., & Carr, A. C. (2022) · Critical Care · doi:10.1186/s13054-022-03900-w · Cited by 70 · see citing works
Luo, M., Fernández‐Estívariz, C., Jones, D. P., Accardi, C. J., Alteheld, B., Bazargan, N., Hao, L., Griffith, D. P., Blumberg, J. B., Galloway, J. R., et al. (2007) · Nutrition · doi:10.1016/j.nut.2007.10.004 · Cited by 70 · see citing works
Mortality in septic patients treated with vitamin C: a systematic meta-analysis
Scholz, S. S., Borgstedt, R., Ebeling, N., Menzel, L. C., Jansen, G., & Rehberg, S. W. (2021) · Critical Care · doi:10.1186/s13054-020-03438-9 · Cited by 69 · see citing works
Belsky, J., Wira, C., Jacob, V., Sather, J., & Lee, P. J. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000124 · Cited by 69 · see citing works
Han, M. H., Pendem, S., Teh, S. L., Sukumaran, D. K., Wu, F. Y., & Wilson, J. X. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.034 · Cited by 66 · see citing works
History of scurvy and use of vitamin C in critical illness: A narrative review
Dresen, E., Lee, Z., Hill, A., Notz, Q., Patel, J. J., & Stoppe, C. (2022) · Nutrition in Clinical Practice · doi:10.1002/ncp.10914 · Cited by 64 · see citing works
Oral preoperative antioxidants in pancreatic surgery: A double-blind, randomized, clinical trial
Braga, M., Bissolati, M., Rocchetti, S., Beneduce, A. A., Pecorelli, N., & Carlo, V. D. (2011) · Nutrition · doi:10.1016/j.nut.2011.05.014 · Cited by 61 · see citing works
Kamel, A. Y., Dave, N. J., Zhao, V. M., Griffith, D. P., Connor, M. J., Jr., & Ziegler, T. R. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533617716618 · Cited by 60 · see citing works
Halcrow, S. E., Harris, N. J., Beavan, N., & Buckley, H. R. (2014) · International Journal of Paleopathology · doi:10.1016/j.ijpp.2014.01.004 · Cited by 59 · see citing works
Carr, A. C., Spencer, E. S., Dixon, L., & Chambers, S. T. (2020) · Nutrients · doi:10.3390/nu12051318 · Cited by 58 · see citing works
Zhou, G., Kamenos, G., Pendem, S., Wilson, J. X., & Wu, F. Y. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00153.2011 · Cited by 57 · see citing works
Mahmoodpoor, A., Shadvar, K., Sanaie, S., Hadipoor, M. R., Pourmoghaddam, M. A., & Saghaleini, S. H. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-06288-0 · Cited by 57 · see citing works
Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities
Dao, D. T., Anez‐Bustillos, L., Cho, B. S., Li, Z., Puder, M., & Gura, K. M. (2017) · Nutrients · doi:10.3390/nu9111185 · Cited by 56 · see citing works
Metabolic origin of hypovitaminosis C in acutely hospitalized patients
Evans-Olders, R., Eintracht, S., & Hoffer, L. J. (2010) · Nutrition · doi:10.1016/j.nut.2009.08.015 · Cited by 54 · see citing works
Vitamin C deficiency and secondary hyperparathyroidism in chronic haemodialysis patients
Richter, A. M., Kuhlmann, M. K., Seibert, E., Kotanko, P., Levin, N. W., & Handelman, G. J. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn084 · Cited by 54 · see citing works
Vitamin C supplementation for diabetes management: A comprehensive narrative review
Mason, S. A., Parker, L., van der Pligt, P., & Wadley, G. D. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.003 · Cited by 53 · see citing works
Sherman, A. R., & Barkley, M. C. (2011) · Journal of Wound Care · doi:10.12968/jowc.2011.20.8.357 · Cited by 53 · see citing works
Vitamin C in Health and Disease: A Companion Animal Focus
Gordon, D. S., Rudinsky, A. J., Guillaumin, J., Parker, V. J., & Creighton, K. J. (2020) · Topics in companion animal medicine · doi:10.1016/j.tcam.2020.100432 · Cited by 55 · see citing works
Nutrition Management of Pressure Ulcers
Doley, J. A. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533609359294 · Cited by 51 · see citing works
Rodemeister, S., Duquesne, M., Adolph, M., Nöhr, D., Biesalski, H. K., & Unertl, K. E. (2013) · Nutrition · doi:10.1016/j.nut.2013.10.026 · Cited by 49 · see citing works
Gandhi, H., Balakrishnan, M., Shah, K. H., Pandya, H., Patel, R., Keshwani, S., & Yadav, N. (2018) · Indian Journal of Anaesthesia · doi:10.4103/ija.ija_361_18 · Cited by 49 · see citing works
Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation
Gaut, J. P., Belaaouaj, A., Byun, J., Roberts, L. J., Maeda, N., Frei, B., & Heinecke, J. W. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.013 · Cited by 48 · see citing works
Snoddy, A. M. E., Halcrow, S. E., Buckley, H. R., Standen, V. G., & Arriaza, B. T. (2017) · International Journal of Paleopathology · doi:10.1016/j.ijpp.2017.05.011 · Cited by 45 · see citing works
The Patient With Circulatory Shock: To Feed or Not to Feed?
Cresci, G., & Cué, J. I. (2008) · Nutrition in Clinical Practice · doi:10.1177/0884533608323431 · Cited by 45 · see citing works
Chow, J. H., Abuelkasem, E., Sankova, S. K., Henderson, R. A., Mazzeffi, M. A., & Tanaka, K. A. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004343 · Cited by 45 · see citing works
Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients
Lavillegrand, J., Raia, L., Urbina, T., Hariri, G., Gabarre, P., Bonny, V., Bigé, N., Baudel, J.-L., Bruneel, A., Dupré, T., et al. (2022) · Critical Care · doi:10.1186/s13054-022-03891-8 · Cited by 43 · see citing works
Lykkesfeldt, J., Carr, A. C., & Tveden‐Nyborg, P. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100043 · Cited by 44 · see citing works
Chang, C., Chen, J., Wu, M., & Hu, M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.05.015 · Cited by 40 · see citing works
Doctor—your septic patients have scurvy!
Marik, P. E., & Hooper, M. H. (2018) · Critical Care · doi:10.1186/s13054-018-1950-z · Cited by 40 · see citing works
RETRACTED ARTICLE: Early use of high-dose vitamin C is beneficial in treatment of sepsis
Lv, S., Guo-hu, Z., Xia, J., Yu, H., & Zhao, F. (2020) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-020-02394-1 · Cited by 40 · see citing works
RetractedNabil Habib, T., & Ahmed, I. (2017) · International Journal of Microbiology & Advanced Immunology · doi:10.19070/2329-9967-1700015 · Cited by 36 · see citing works
Ahn, J. H., Oh, D. K., Huh, J. W., Lim, C., Koh, Y., & Hong, S. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.03.03 · Cited by 36 · see citing works
Yanase, F., Bitker, L., Hessels, L., Osawa, E., Naorungroj, T., Cutuli, S. L., Young, P. J., Ritzema, J., Hill, G., Latimer-Bell, C., et al. (2019) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2019.08.034 · Cited by 37 · see citing works
Sae‐khow, K., Tachaboon, S., Wright, H. L., Edwards, S. W., Srisawat, N., Leelahavanichkul, A., & Chiewchengchol, D. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s252433 · Cited by 37 · see citing works
Vitamin C measurement in critical illness: challenges, methodologies and quality improvements
Collie, J. T. B., Greaves, R. F., Jones, O. A. H., Eastwood, G. M., & Bellomo, R. (2019) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-0912 · Cited by 35 · see citing works
Hudson, E. P., Collie, J. T. B., Fujii, T., Luethi, N., Udy, A. A., Doherty, S., Eastwood, G. M., Yanase, F., Naorungroj, T., Bitker, L., et al. (2019) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00548-3 · Cited by 35 · see citing works
Jain, S. K., Dar, M. Y., Kumar, S., Yadav, A. K., & Kearns, S. R. (2018) · Foot and Ankle Surgery · doi:10.1016/j.fas.2018.05.001 · Cited by 35 · see citing works
Resolution of Sterile Inflammation: Role for Vitamin C
Mohammed, B. M., Fisher, B. J., Huynh, Q. K., Wijesinghe, D. S., Chalfant, C. E., Brophy, D. F., Fowler, A. A., & Natarajan, R. (2014) · Mediators of Inflammation · doi:10.1155/2014/173403 · Cited by 34 · see citing works
Effect of vitamin C on the growth of experimentally induced endometriotic cysts
Durak, Y., Kökçü, A., Kefeli, M., Bıldırcın, D., Çelik, H., & Alper, T. (2013) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12050 · Cited by 33 · see citing works
Wilson, J. X., & Wu, F. (2012) · Subcellular Biochemistry · doi:10.1007/978-94-007-2199-9_5 · Cited by 32 · see citing works
Hemoglobin and Plasma Vitamin C Levels in Patients on Peritoneal Dialysis
Finkelstein, F. O., Juergensen, P. H., Wang, S., Santacroce, S., Levine, M., Kotanko, P., Levin, N. W., & Handelman, G. J. (2010) · Peritoneal Dialysis International · doi:10.3747/pdi.2009.00154 · Cited by 32 · see citing works
Honoré, P. M., Spapen, H. D., Marik, P. E., Boer, W., & Straaten, H. M. O. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-0640-6 · Cited by 30 · see citing works
He, J., Xu, W., Zheng, X., Zhao, B., Ni, T., Yu, P., Deng, S., Pan, X., Chen, E., Mao, E., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-3294 · Cited by 31 · see citing works
Holley, A., Osland, E., Barnes, J., Krishnan, A., & Fraser, J. F. (2011) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2010.02413.x · Cited by 31 · see citing works
Behrend, H., Lengnick, H., Zdravkovic, V., Ladurner, A., Rudin, D., Erschbamer, M., Joerger, M., & Kuster, M. S. (2018) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-018-5030-3 · Cited by 29 · see citing works
- Authors
- Long, C. L., Maull, K. I., Krishnan, R. S., Laws, H. L., Geiger, J. W., Borghesi, L., Franks, W., Lawson, T. C., & Sauberlich, H. E.
- Affiliations
- Carraway Methodist Medical Center (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Maull, K.I
- ORCID
- Long, C.L
- Venue
- Journal of Surgical Research
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 109
- Issue
- 2
- Pages
- 144-148
- ISSN
- 0022-4804 (ISSN-L)
- OpenAlex
- W2136795074
- Cited by
- 254
- References
- 34
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 15 · 2022: 20 · 2021: 25 · 2020: 24 · 2019: 25 · 2018: 19 · 2017: 6 · 2016: 10 · 2015: 4 · 2014: 12 · 2013: 13 · 2012: 4
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Surgical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Keywords
- vitamin C, total parenteral nutrition, critically injured patients, trauma (physical injury), sepsis, plasma ascorbic acid levels, vitamin C supplementation, antioxidants, wound healing, immune response, oxidative damage
- MeSH terms
- Adult, Antioxidants, Ascorbic Acid, Female, Humans, Male, Middle Aged, Parenteral Nutrition, Total, Time Factors, Wounds and Injuries, Critical Illness, Sepsis
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