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Diabetes mellitus and free radicals
Abstract
Diabetes mellitus is a syndrome initially characterized by a loss of glucose homeostasis. The disease is progressive and is associated with high risk of atherosclerosis, kidney and nerve damage as well as blindness. Abnormalities in the regulation of peroxide and transition metal metabolism are postulated to result in establishment of the disease as well as its longer term complications. Diabetes mellitus is associated with oxidative reactions, particularly those which are catalyzed by decompartmentalized transition metals, but their causative significance in diabetic tissue damage remains to be established.
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“Iron 'excess' is also a known feature of gestational diabetes [591-593], and is a clear risk factor for the disease even in 'normal' populations [594-603], and indeed diabetes is a classical consequence of iron overloading as seen in hereditary haemochromatosis [604].”
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Metadata
- Authors
- Wolff, S. P.
- Affiliations
- University College London (GB)
- Corresponding author
- Wolff, S P
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1993
- Volume
- 49
- Issue
- 3
- Pages
- 642-652
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W1953115230
- Cited by
- 660
- References
- 0
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 17 · 2018: 11 · 2017: 15 · 2016: 22 · 2015: 32 · 2014: 35 · 2013: 29 · 2012: 31
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Medical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- diabetes mellitus, free radicals, oxidative stress, glucose homeostasis, peroxide metabolism, atherosclerosis, diabetes complications, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy
- MeSH terms
- Alloxan, Animals, Arginine, Diabetes Mellitus, Free Radicals, Glucose, Humans, Lysine, Metals, Oxidation-Reduction, Oxygen Consumption, Streptozocin, Lipid Peroxidation, Reactive Oxygen Species, Diabetes Complications, Rats
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