Cited by 986Genomics and Phylogenetic StudiesEvolution and Genetic DynamicsBacterial Genetics and Biotechnology

The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

Prokaryotic Evolution in Light of Gene Transfer

Gogarten, J. Peter, Doolittle, W. Ford, Lawrence, Jeffrey G.·2002·Molecular Biology and Evolution

Abstract

Accumulating prokaryotic gene and genome sequences reveal that the exchange of genetic information through both homology-dependent recombination and horizontal (lateral) gene transfer (HGT) is far more important, in quantity and quality, than hitherto imagined. The traditional view, that prokaryotic evolution can be understood primarily in terms of clonal divergence and periodic selection, must be augmented to embrace gene exchange as a creative force, itself responsible for much of the pattern of similarities and differences we see between prokaryotic microbes. Rather than replacing periodic selection on genetic diversity, gene loss, and other chromosomal alterations as important players in adaptive evolution, gene exchange acts in concert with these processes to provide a rich explanatory paradigm-some of whose implications we explore here. In particular, we discuss (1) the role of recombination and HGT in giving phenotypic "coherence" to prokaryotic taxa at all levels of inclusiveness, (2) the implications of these processes for the reconstruction and meaning of "phylogeny," and (3) new views of prokaryotic adaptation and diversification based on gene acquisition and exchange.

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Crossref · 10.1093/oxfordjournals.molbev.a004046

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  • Substantial horizontal gene transfer (HGT) has occurred between microorganisms.

    “The recognition that substantial horizontal gene transfer (HGT) has occurred between microorganisms raised concerns that genes might be transferred with high enough frequency as to seriously challenge the notion of a universal tree of life (e.g.Doolittle 1999; Gogarten et al. 2002).”

    From The Emergence of Life (2019) · cites this paper as Gogarten et al. 2002

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Research works printed but not linked: 1

  1. Wright S., 1932 The roles of mutation, inbreeding, crossbreeding, and selection in evolution Proc. 6th Int. Congr. Genet1:356-366

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Metadata

Authors
Gogarten, J. P., Doolittle, W. F., & Lawrence, J. G.
Affiliations
University of Connecticut (US)
Venue
Molecular Biology and Evolution
Published
2002-12-01
Volume
19
Issue
12
Pages
2226-2238
ISSN
  • 0737-4038 (ISSN-L)
  • 1537-1719
OpenAlex
W2110105435
Cited by
986
References
132
Citations by year
2026: 16 · 2025: 16 · 2024: 19 · 2023: 18 · 2022: 27 · 2021: 31 · 2020: 37 · 2019: 31 · 2018: 33 · 2017: 32 · 2016: 45 · 2015: 39 · 2014: 47 · 2013: 57 · 2012: 51
FWCI
16.65
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Biology and Evolution (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • David and Lucile Packard Foundation
  • National Aeronautics and Space Administration
  • Canadian Institute for Advanced Research
  • Canada Research Chairs
  • Health Canada
  • Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
prokaryotic evolution, horizontal gene transfer, homologous recombination, genetic exchange, phylogeny, diversification, gene loss, clonal divergence
MeSH terms
Phylogeny, Prokaryotic Cells, Evolution, Molecular, Gene Transfer, Horizontal

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