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Cited by 283

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Recent Advances in the Neuropathology of Schizophrenia

Bogerts, B.·1993·Schizophrenia Bulletin
DOI 10.1093/schbul/19.2.431
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Abstract

This article reviews some 50 neuroanatomical postmortem studies published in the last 20 years. The majority of these studies demonstrated various types of subtle anomalies in limbic structures, that is, the hippocampus, parahippocampal gyrus, entorhinal cortex, amygdala, cingulate gyrus, and septum of schizophrenia patients. A number of schizophrenic symptoms might be related to structural and functional disturbances of these brain regions. But these studies also reported subtle changes in parts of the basal ganglia, thalamus, cortex, corpus callosum, and brainstem neurotransmitter systems. Many of the studies, however, are based on small sample sizes and, therefore, must be regarded as preliminary. Cytoarchitectonic abnormalities and lack of gliosis in limbic structures as well as the absence of normal structural cerebral asymmetry in a substantial proportion of patients indicate that these structural anomalies may reflect a disorder of prenatal brain development and argue against the notion that schizophrenia is a progressive degenerative brain disorder.

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Metadata

Authors
Bogerts, B.
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
1993-01-01
Volume
19
Issue
2
Pages
431-445
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/19.2.431
OpenAlex
W2075900490
Cited by
283
References
4
FWCI
20.35
Type
journal article
Language
en
Open access
closed

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