Cited by 290Schizophrenia research and treatmentMental Health and PsychiatryPersonality Traits and Psychology

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Affective Traits in Schizophrenia and Schizotypy

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Horan, W. P., Blanchard, J. J., Clark, L. A., Green, M. F.·2008·Schizophrenia Bulletin

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Abstract

This article reviews empirical studies of affective traits in individuals with schizophrenia spectrum disorders, population-based investigations of vulnerability to psychosis, and genetic and psychometric high-risk samples. The review focuses on studies that use self-report trait questionnaires to assess Negative Affectivity (NA) and Positive Affectivity (PA), which are conceptualized in contemporary models of personality as broad, temperamentally-based dispositions to experience corresponding emotional states. Individuals with schizophrenia report a pattern of stably elevated NA and low PA throughout the illness course. Among affected individuals, these traits are associated with variability in several clinically important features, including functional outcome, quality of life, and stress reactivity. Furthermore, evidence that elevated NA and low PA (particularly the facet of anhedonia) predict the development of psychosis and are detectable in high-risk samples suggests that these traits play a role in vulnerability to schizophrenia, though they are implicated in other forms of psychopathology as well. Results are discussed in terms of their implications for treatment, etiological models, and future research to advance the study of affective traits in schizophrenia and schizotypy.

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Self-citation
A transdiagnostic evaluation of adult temperamental profiles and their interactions with childhood adversities across major psychiatric disorder.
Dayalamurthy, P., Balachander, S., Lakkireddy, S. P., Bhattacharya, M., Joseph, M. S., Kumar, P., Kannampuzha, A. J., Mallappagari, S., Narayana, S., Alexander, A. C., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122460

Authors: Horan, W. P., Blanchard, J. J., Clark, L. A., & Green, M. F.
Affiliations: University of California, Los Angeles (US)
University of Maryland, College Park (US)
University of Iowa (US)
Corresponding author: Horan, W. P.
ORCID: Blanchard, J. J.
Clark, L. A.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 2008-07-21
Volume: 34
Issue: 5
Pages: 856-874
ISSN: 0586-7614 (ISSN-L)
1745-1701
DOI: 10.1093/schbul/sbn083
PMC: PMC2632479
OpenAlex: W2110072357
Cited by: 290
References: 220
Citations by year: 2026: 6 · 2025: 9 · 2024: 11 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 20 · 2018: 20 · 2017: 13 · 2016: 19 · 2015: 24 · 2014: 23 · 2013: 29 · 2012: 23
FWCI: 1.84
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Schizophrenia Bulletin (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH065707, MH077141, MH65707, MH 079231, R03MH077141, K02MH079231, MH 43292)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
Keywords: emotional characteristics, schizophrenia
MeSH terms: Affect, Humans, Psychometrics, Schizophrenia, Schizophrenic Psychology, Schizotypal Personality Disorder

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Affective Traits in Schizophrenia and Schizotypy

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