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Affective Traits in Schizophrenia and Schizotypy
Open accessAbstract
This article reviews empirical studies of affective traits in individuals with schizophrenia spectrum disorders, population-based investigations of vulnerability to psychosis, and genetic and psychometric high-risk samples. The review focuses on studies that use self-report trait questionnaires to assess Negative Affectivity (NA) and Positive Affectivity (PA), which are conceptualized in contemporary models of personality as broad, temperamentally-based dispositions to experience corresponding emotional states. Individuals with schizophrenia report a pattern of stably elevated NA and low PA throughout the illness course. Among affected individuals, these traits are associated with variability in several clinically important features, including functional outcome, quality of life, and stress reactivity. Furthermore, evidence that elevated NA and low PA (particularly the facet of anhedonia) predict the development of psychosis and are detectable in high-risk samples suggests that these traits play a role in vulnerability to schizophrenia, though they are implicated in other forms of psychopathology as well. Results are discussed in terms of their implications for treatment, etiological models, and future research to advance the study of affective traits in schizophrenia and schizotypy.
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“Moreover, psychosis-spectrum samples are heterogeneous, with multiple symptom and trait profiles typically present in any given sample (e.g., Cowan et al., 2020; Dickinson et al., 2018; Horan et al., 2008).”
From Narrative identity in the psychosis spectrum: A systematic review and developmental model (2021) · cites this paper as Horan et al., 2008
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Emotional Response Deficits in Schizophrenia: Insights From Affective Science
Kring, A. M., & Moran, E. K. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn071 · Cited by 458
A New Perspective on Anhedonia in Schizophrenia
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Evidence of a dimensional relationship between schizotypy and schizophrenia: A systematic review
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Metadata
- Authors
- Horan, W. P., Blanchard, J. J., Clark, L. A., & Green, M. F.
- Affiliations
- University of California, Los Angeles (US)
- University of Maryland, College Park (US)
- University of Iowa (US)
- Corresponding author
- Horan, W. P.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-21
- Volume
- 34
- Issue
- 5
- Pages
- 856-874
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC2632479
- OpenAlex
- W2110072357
- Cited by
- 290
- References
- 220
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 20 · 2018: 20 · 2017: 13 · 2016: 19 · 2015: 24 · 2014: 23 · 2013: 29 · 2012: 23
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH065707, MH077141, MH65707, MH 079231, R03MH077141, K02MH079231, MH 43292)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Keywords
- emotional characteristics, schizophrenia
- MeSH terms
- Affect, Humans, Psychometrics, Schizophrenia, Schizophrenic Psychology, Schizotypal Personality Disorder
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