Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology
Open accessAbstract
Background Gene-environment interactions (GEI) are involved in the pathogenesis of mental diseases. We evaluated interaction between mutant human disrupted-in-schizophrenia 1 (mhDISC1) and maternal immune activation implicated in schizophrenia and mood disorders.Methods Pregnant mice were treated with saline or polyinosinic:polycytidylic acid at gestation day 9. Levels of inflammatory cytokines were measured in fetal and adult brains; expression of mhDISC1, endogenous DISC1, lissencephaly type 1, nuclear distribution protein nudE-like 1, glycoprotein 130, growth factor receptor-bound protein 2, and glycogen synthase kinase-3beta were assessed in cortical samples of newborn mice. Tissue content of monoamines, volumetric brain abnormalities, dendritic spine density in the hippocampus, and various domains of the mouse behavior repertoire were evaluated in adult male mice.Results Prenatal interaction produced anxiety, depression-like responses, and altered social behavior that were accompanied by decreased reactivity of the hypothalamic-pituitary-adrenal axis, attenuated serotonin neurotransmission in the hippocampus, reduced enlargement of lateral ventricles, decreased volumes of amygdala and periaqueductal gray matter and density of spines on dendrites of granule cells of the hippocampus. Prenatal interaction modulated secretion of inflammatory cytokines in fetal brains, levels of mhDISC1, endogenous mouse DISC1, and glycogen synthase kinase-3beta. The behavioral effects of GEI were observed only if mhDISC1 was expressed throughout the life span.Conclusions Prenatal immune activation interacted with mhDISC1 to produce the neurobehavioral phenotypes that were not seen in untreated mhDISC1 mice and that resemble aspects of major mental illnesses. Our DISC1 mouse model is a valuable system to study GEI relevant to mental illnesses.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prenatal poly(I:C) exposure increased 5-HT levels in hippocampus in one study.
“In contrast, one study found that prenatal poly(I:C) exposure increased 5-HT levels in the hippocampus (Abazyan et al., 2010).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Abazyan et al., 2010
Prenatal maternal immune activation and expression of a mutant DISC1 protein interacted to produce an altered pattern of sociability in mice.
“prenatal maternal immune activation and expression of a mutant DISC1 protein interacted to produce an altered pattern of sociability.”
From Autism risk factors: genes, environment, and gene-environment interactions (2012) · cites this paper as [107]
The altered neurobehavioral profile was absent in untreated mice expressing the mutant DISC1 protein.
“This neurobehavioral profile was absent in untreated mice expressing the mutant.”
From Autism risk factors: genes, environment, and gene-environment interactions (2012) · cites this paper as [107]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346 · see citing works
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · cited 1× · see citing works
“In addition, elevated levels and decreased turnover of 5-HT in the hippocampus in mhDISC1 mice treated with Poly I:C are reminiscent of serotonin abnormalities associated with affective states (64,81,82).”
Cryan, J. F., Mombereau, C., & Vassout, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.009 · Cited by 1,674 · see citing works
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605 · see citing works
Disruption of two novel genes by a translocation co-segregating with schizophrenia
Millar, J. K. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1415 · Cited by 1,254 · see citing works
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244 · see citing works
Translating developmental time across mammalian species
Clancy, B., Darlington, R. B., & Finlay, B. L. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00171-3 · Cited by 1,221 · see citing works
A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety
Hogg, S. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02126-4 · Cited by 1,169 · see citing works
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058 · see citing works
Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025 · see citing works
The Neurodevelopmental Hypothesis of Schizophrenia, Revisited
Fatemi, S. H., & Folsom, T. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn187 · Cited by 860 · see citing works
GSK3 signalling in neural development
Hur, E., & Zhou, F. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2870 · Cited by 828 · see citing works
The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings
Strakowski, S. M., DelBello, M. P., & Adler, C. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001585 · Cited by 818 · see citing works
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776 · see citing works
Meyer, U., Nyffeler, M., Engler, A., Urwyler, A., Schedlowski, M., Knuesel, I., Yee, B. K., & Feldon, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0099-06.2006 · Cited by 774 · see citing works
Mao, Y., Ge, X., Frank, C. L., Madison, J. M., Koehler, A. N., Doud, M. K., Tassa, C., Berry-Scott, E., Soda, T., Singh, K. K., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.044 · Cited by 768 · see citing works
Exploratory behavior models of anxiety in mice
Crawley, J. N. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90030-2 · Cited by 756 · see citing works
van Os, J., Rutten, B. P., & Poulton, R. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn117 · Cited by 713 · see citing works
Ross, C. A., Margolis, R. L., Reading, S. A. J., Pletnikov, M. V., & Coyle, J. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.015 · Cited by 697 · see citing works
Self-citationThe immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
Müller, N., & Schwarz, M. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002006 · Cited by 670 · see citing works
Cryan, J. F., & Mombereau, C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001457 · Cited by 616 · see citing works
Khashan, A. S., Abel, K. M., McNamee, R., Pedersen, M. G., Webb, R. T., Baker, P. N., Kenny, L. C., & Mortensen, P. B. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.20 · Cited by 576 · see citing works
The DISC locus in psychiatric illness
Chubb, J. E., Bradshaw, N. J., Soares, D. C., Porteous, D. J., & Millar, J. K. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002106 · Cited by 542 · see citing works
Prenatal Infection as a Risk Factor for Schizophrenia
Brown, A. S. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj052 · Cited by 540 · see citing works
Meta-analysis, Database, and Meta-regression of 98 Structural Imaging Studies in Bipolar Disorder
Kempton, M. J., Geddes, J. R., Ettinger, U., Williams, S., & Grasby, P. M. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.9.1017 · Cited by 533 · see citing works
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development
Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, C., Okawa, M., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1328 · Cited by 531 · see citing works
Self-citationBehavioral phenotypes of Disc1 missense mutations in mice
Clapcote, S. J., Lipina, T. V., Millar, J. K., Mackie, S., Christie, S., Ogawa, F., Lerch, J. P., Trimble, K., Uchiyama, M., Sakuraba, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.015 · Cited by 526 · see citing works
Zuckerman, L., Rehavi, M., Nachman, R., & Weiner, I. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300248 · Cited by 501 · see citing works
Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis
Arnone, D., Cavanagh, J., Gerber, D., Lawrie, S. M., Ebmeier, K. P., & McIntosh, A. M. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.059717 · Cited by 441 · see citing works
Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704774104 · Cited by 417 · see citing works
Self-citationHaddad, J. J., Saadé, N. E., & Safieh‐Garabedian, B. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00357-0 · Cited by 416 · see citing works
Corticosteroid hormones in the central stress response: Quick-and-slow
de Kloet, E. R., Karst, H., & Joëls, M. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.002 · Cited by 391 · see citing works
Ashdown, H. F., Dumont, Y., Ng, M., Poole, S., Boksa, P., & Luheshi, G. N. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001748 · Cited by 387 · see citing works
Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)
Beurel, E., Michalek, S. M., & Jope, R. S. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.007 · Cited by 378 · see citing works
Fortier, M., Kent, S., Ashdown, H. F., Poole, S., Boksa, P., & Luheshi, G. N. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00293.2004 · Cited by 354 · see citing works
Pletnikov, M. V., Ayhan, Y., Nikolskaia, O. V., Xu, Y., Ovanesov, M. V., Huang, H., Mori, S., Moran, T. H., & Ross, C. A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002079 · Cited by 339 · see citing works
Self-citationAre some cases of psychosis caused by microbial agents? A review of the evidence
Yolken, R. H., & Torrey, E. F. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.5 · Cited by 327 · see citing works
A Review of the Fetal Brain Cytokine Imbalance Hypothesis of Schizophrenia
Meyer, U., Feldon, J., & Yee, B. K. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn022 · Cited by 318 · see citing works
Role of the amygdala and periaqueductal gray in anxiety and panic.
Graeff, F. G., Silveira, M. C. L., Nogueira, R. L., Audi, E. A., & Oliveira, R. M. W. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90097-a · Cited by 301 · see citing works
Konarski, J. Z., McIntyre, R. S., Kennedy, S. H., Rafi‐Tari, S., Soczynska, J. K., & Ketter, T. A. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00435.x · Cited by 297 · see citing works
Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder
McDonald, C., Zanelli, J., Rabe‐Hesketh, S., Ellison-Wright, I., Sham, P. C., Kalidindi, S., Murray, R. M., & Kennedy, N. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.021 · Cited by 295 · see citing works
Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia
Sweet, R. A., Henteleff, R. A., Zhang, W., Sampson, A. R., & Lewis, D. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.67 · Cited by 290 · see citing works
Kvajo, M., McKellar, H., Arguello, P. A., Drew, L. J., Moore, H., MacDermott, A. B., Karayiorgou, M., & Gogos, J. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802615105 · Cited by 268 · see citing works
In utero infection and adult schizophrenia
Brown, A. S., & Susser, E. (2002) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10004 · Cited by 261 · see citing works
Association Between Prenatal Exposure to Bacterial Infection and Risk of Schizophrenia
Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn121 · Cited by 261 · see citing works
Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing TruncatedDisc1
Shen, S., Lang, B., Nakamoto, C., Zhang, F., Pu, J., Kuan, S. L., Chatzi, C. A., He, S., Mackie, I., Brandon, N. J., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3299-08.2008 · Cited by 250 · see citing works
Kolluri, N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1200 · Cited by 241 · see citing works
The psychoneuroimmunology of depression
Leonard, B. E., & Myint, A.-M. (2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1011 · Cited by 236 · see citing works
Sankoorikal, G. M. V., Kaercher, K. A., Boon, C. J., Lee, J. K., & Brodkin, E. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.026 · Cited by 231 · see citing works
Sachs, N. A., Sawa, A., Holmes, S. E., Ross, C. A., DeLisi, L. E., & Margolis, R. L. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001667 · Cited by 221 · see citing works
Self-citationMillar, J. K., CHRISTIE, S., Anderson, S. M., Lawson, D., Loh, D. H., Devon, R. S., Arveiler, B., Muir, W. J., Blackwood, D., & Porteous, D. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000784 · Cited by 202 · see citing works
Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development
Brandon, N. J., Millar, J. K., Korth, C., Sive, H., Singh, K. K., & Sawa, A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3355-09.2009 · Cited by 198 · see citing works
Self-citationLawrie, S. M., McIntosh, A. M., Hall, J., Owens, D. G. C., & Johnstone, E. C. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm158 · Cited by 192 · see citing works
Gene-environment interactions in mental disorders.
Tsuang, M. T., Bar, J. L., Stone, W. S., & Faraone, S. V. (2004) · Europe PMC (PubMed Central) · Cited by 179 · see citing works
Gilmore, J. H., Jarskog, L. F., & Vadlamudi, S. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.008 · Cited by 177 · see citing works
Maternal Effects on Schizophrenia Risk
Patterson, P. H. (2007) · Science · doi:10.1126/science.1150196 · Cited by 175 · see citing works
Nawa, H., & Takei, N. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.002 · Cited by 174 · see citing works
The Genetics and Biology of Disc1—An Emerging Role in Psychosis and Cognition
Porteous, D. J., Thomson, P. A., Brandon, N. J., & Millar, J. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.008 · Cited by 172 · see citing works
DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder
Hennah, W., Thomson, P. A., McQuillin, A., Bass, N. J., Loukola, A., Anjorin, A., Blackwood, D., Curtis, D., Deary, I. J., Harris, S. E., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.22 · Cited by 165 · see citing works
Rydmark, I., Wahlberg, K., Ghatan, P. H., Modell, S., Nygren, Å., Ingvar, M., Åsberg, M., & Heilig, M. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.029 · Cited by 157 · see citing works
Hennah, W., Tuulio‐Henriksson, A., Paunio, T., Ekelund, J., Varilo, T., Partonen, T., Cannon, T. D., Lönnqvist, J. K., & Peltonen, L. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001731 · Cited by 156 · see citing works
Schizophrenia and viral infection during neurodevelopment: a focus on mechanisms
Pearce, B. D. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000956 · Cited by 152 · see citing works
Li, Q., Cheung, C., Wei, R., Hui, E. S. K., Feldon, J., Meyer, U., Chung, S. K., Chua, S. E., Sham, P. C., Wu, E. X., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006354 · Cited by 149 · see citing works
Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2009.144 · Cited by 148 · see citing works
Self-citationPiontkewitz, Y., Assaf, Y., & Weiner, I. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.005 · Cited by 143 · see citing works
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood
Ibi, D., Nagai, T., Koike, H., Kitahara, Y., Mizoguchi, H., Niwa, M., Jaaro-Peled, H., Nitta, A., Yoneda, Y., & Nabeshima, T. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.027 · Cited by 137 · cited 2× · see citing works
“In contrast to a previous study that injected Poly I:C into developing DISC1 mouse pups (36), we employed a widely used prenatal challenge with Poly I:C that is likely to be more relevant to the human situation, and to mimic maternal immune activation following microbial infections in humans (20–24).”
Blunted cortisol response to a psychosocial stressor in schizophrenia
Jansen, L. M. C., Wied, C. C. G., Gademan, P. J., de Jonge, R. C. J., van der Linden, J. A., & Kahn, R. S. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00066-8 · Cited by 135 · see citing works
Prenatal and postnatal maternal contributions in the infection model of schizophrenia
Meyer, U., Schwendener, S., Feldon, J., & Yee, B. K. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0419-5 · Cited by 128 · see citing works
Millar, J. K., Christie, S., Semple, C. A. M., & Porteous, D. J. (2000) · Genomics · doi:10.1006/geno.2000.6239 · Cited by 114 · see citing works
Baharnoori, M., Brake, W. G., & Srivastava, L. K. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.10.003 · Cited by 113 · see citing works
Panic Disorder: Is the PAG Involved?
Del‐Ben, C. M., & Graeff, F. G. (2009) · Neural Plasticity · doi:10.1155/2009/108135 · Cited by 92 · see citing works
Animal models of gene–environment interactions in schizophrenia
Ayhan, Y., Sawa, A., Ross, C. A., & Pletnikov, M. V. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.010 · Cited by 87 · see citing works
Self-citationAlterations of dopamine and serotonin transmission in schizophrenia
Remington, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00906-0 · Cited by 81 · see citing works
Hennah, W., & Porteous, D. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004906 · Cited by 79 · see citing works
Dendritic Spine Density in Schizophrenia and Depression
Glantz, L. A., & Lewis, D. A. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.2.203 · Cited by 73 · see citing works
Lowe, G. C., Luheshi, G. N., & Williams, S. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90350.2008 · Cited by 64 · see citing works
Genetic causality in schizophrenia and bipolar disorder: out with the old and in with the new
Porteous, D. J. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.005 · Cited by 60 · see citing works
The role of the amygdala in bipolar disorder development
Garrett, A., & Chang, K. D. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000618 · Cited by 52 · see citing works
WOOD, M., & Wren, P. B. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00911-4 · Cited by 42 · see citing works
Pletnikov, M. V., Xu, Y., Ovanesov, M. V., Kamiya, A., Sawa, A., & Ross, C. A. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.03.003 · Cited by 36 · see citing works
Self-citationRosoklija, G., Toomayan, G., Ellis, S. P., Keilp, J., Mann, J. J., Latov, N., Hays, A. P., & Dwork, A. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.349 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Maternal immune activation and abnormal brain development across CNS disorders
Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880 · see citing works
Autism risk factors: genes, environment, and gene-environment interactions
Chaste, P., & Leboyer, M. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/pchaste · Cited by 807 · see citing works
Animal models of schizophrenia
Jones, C., Watson, D., & Fone, K. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01386.x · Cited by 771 · see citing works
Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems
Meyer, U. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.011 · Cited by 626 · see citing works
Maternal infection and immune involvement in autism
Patterson, P. H. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.03.001 · Cited by 520 · see citing works
Linking neurodevelopmental and synaptic theories of mental illness through DISC1
Brandon, N. J., & Sawa, A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3120 · Cited by 422 · see citing works
Self-citationGaray, P. A., Hsiao, E. Y., Patterson, P. H., & McAllister, A. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.008 · Cited by 366 · see citing works
Millan, M. J., Fone, K. C. F., Steckler, T., & Horan, W. P. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.008 · Cited by 354 · see citing works
Maternal immune activation and autism spectrum disorder: From rodents to nonhuman and human primates
Careaga, M., Murai, T., & Bauman, M. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.020 · Cited by 348 · see citing works
Luczynski, P., Whelan, S. O., O'SULLIVAN, C. T. D., Clarke, G. A., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13291 · Cited by 345 · see citing works
Neuroinflammation as a risk factor for attention deficit hyperactivity disorder
Dunn, G. A., Nigg, J. T., & Sullivan, E. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.005 · Cited by 299 · see citing works
Maternal Immune Activation and Neuropsychiatric Illness: A Translational Research Perspective
Brown, A. S., & Meyer, U. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17121311 · Cited by 285 · see citing works
Inflammation and the two-hit hypothesis of schizophrenia
Feigenson, K. A., Kusnecov, A., & Silverstein, S. M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.006 · Cited by 280 · see citing works
Brain changes in a maternal immune activation model of neurodevelopmental brain disorders
Bergdolt, L., & Dunaevsky, A. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.002 · Cited by 266 · see citing works
Erickson, M. A., & Banks, W. A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.006 · Cited by 262 · see citing works
The fetal origins of mental illness
al-Haddad, B. J. S., Oler, E., Armistead, B., Elsayed, N. A., Weinberger, D. R., Bernier, R., Burd, I. D., Kapur, R. P., Jacobsson, B., Wang, C., et al. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.06.013 · Cited by 265 · see citing works
Kentner, A. C., Bilbo, S. D., Brown, A. S., Hsiao, E. Y., McAllister, A. K., Meyer, U., Pearce, B. D., Pletnikov, M. V., Yolken, R. H., & Bauman, M. D. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0185-7 · Cited by 245 · see citing works
Self-citationMeyer, U., & Feldon, J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.009 · Cited by 247 · see citing works
Sex, glia, and development: Interactions in health and disease
Schwarz, J. M., & Bilbo, S. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.018 · Cited by 247 · see citing works
Neurodevelopment, GABA System Dysfunction, and Schizophrenia
Schmidt, M. J., & Mirnics, K. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.95 · Cited by 239 · see citing works
Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders
Gibney, S. M., & Drexhage, H. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9462-8 · Cited by 237 · see citing works
Schwartzer, J. J., Careaga, M., Onore, C. E., Rushakoff, J. A., Berman, R. F., & Ashwood, P. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.16 · Cited by 227 · see citing works
Gastrointestinal inflammation and associated immune activation in schizophrenia
Severance, E. G., Alaedini, A., Yang, S., Halling, M., Gressitt, K. L., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Leweke, F. M., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.025 · Cited by 226 · see citing works
Haddad, F. L., Patel, S. V., & Schmid, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.012 · Cited by 195 · see citing works
Mattei, D., Djodari-Irani, A., Hadar, R., Pelz, A., de Cossío, L. F., Goetz, T., Matyash, M., Kettenmann, H., Winter, C., & Wolf, S. A. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.01.019 · Cited by 188 · see citing works
Microglia as modulators of cognition and neuropsychiatric disorders
Blank, T., & Prinz, M. (2012) · Glia · doi:10.1002/glia.22372 · Cited by 185 · see citing works
Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap
Pratt, J. A., Winchester, C. L., Dawson, N., & MORRIS, B. J. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3649 · Cited by 189 · see citing works
Immune System Disturbances in Schizophrenia
Horváth, S., & Mirnics, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.010 · Cited by 177 · see citing works
Wnt signaling networks in autism spectrum disorder and intellectual disability
Kwan, V., Unda, B. K., & Singh, K. K. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9176-3 · Cited by 171 · see citing works
Maternal immune activation in neurodevelopmental disorders
Solek, C. M., Farooqi, N., Verly, M., Lim, T. K., & Ruthazer, E. S. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24612 · Cited by 168 · see citing works
The development of autism spectrum disorders: variability and causal complexity
Wozniak, R. H., Leezenbaum, N. B., Northrup, J. B., West, K. L., & Iverson, J. M. (2016) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1426 · Cited by 162 · see citing works
Implications for reactive oxygen species in schizophrenia pathogenesis
Koga, M., Serritella, A. V., Sawa, A., & Sedlak, T. W. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.022 · Cited by 159 · see citing works
Self-citationMottahedin, A., Ardalan, M., Chumak, T., Riebe, I., Ek, C. J., & Mallard, C. E. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00190 · Cited by 149 · see citing works
Lipina, T. V., Zai, C. C. H., Hlousek, D., Roder, J., & Wong, A. H. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0091-13.2013 · Cited by 146 · see citing works
Abnormal Trajectories of Neurodevelopment and Behavior Following In Utero Insult in the Rat
Piontkewitz, Y., Arad, M., & Weiner, I. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.007 · Cited by 144 · see citing works
Madore, C., Leyrolle, Q., Lacabanne, C., Benmamar-Badel, A., Joffre, C., Nadjar, A., & Layé, S. (2016) · Neural Plasticity · doi:10.1155/2016/3597209 · Cited by 141 · see citing works
DISC1 at 10: connecting psychiatric genetics and neuroscience
Porteous, D. J., Millar, J. K., Brandon, N. J., & Sawa, A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.09.002 · Cited by 137 · see citing works
Self-citationMueller, F. S., Scarborough, J., Schalbetter, S. M., Richetto, J., Kim, E., Couch, A. C. M., Yee, Y., Lerch, J. P., Vernon, A. C., Weber‐Stadlbauer, U., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00952-8 · Cited by 133 · see citing works
Vuillermot, S., Joodmardi, E., Perlmann, T., Ove Ögren, S., Feldon, J., & Meyer, U. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4831-11.2012 · Cited by 127 · see citing works
Prenatal inflammation and neurodevelopment in schizophrenia: A review of human studies
Miller, B. J., Culpepper, N. H., Rapaport, M. H., & Buckley, P. F. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.03.010 · Cited by 124 · see citing works
Mueller, F. S., Richetto, J., Hayes, L. N., Zambon, A., Pollak, D. D., Sawa, A., Meyer, U., & Weber‐Stadlbauer, U. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.019 · Cited by 126 · see citing works
Self-citationGiovanoli, S., Notter, T., Richetto, J., Labouesse, M. A., Vuillermot, S., Riva, M. A., & Meyer, U. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0437-y · Cited by 124 · see citing works
Long-term effects of maternal immune activation on depression-like behavior in the mouse
Khan, D., Fernando, P. M., Cicvaric, A., Berger, A., Pollak, A. J., Monje, F. J., & Pollak, D. D. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.132 · Cited by 118 · see citing works
Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works
Mouse models of maternal immune activation: Mind your caging system!
Mueller, F. S., Polesel, M., Richetto, J., Meyer, U., & Weber‐Stadlbauer, U. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.014 · Cited by 107 · see citing works
de Bartolomeis, A., Barone, A., Vellucci, L., Mazza, B., Austin, M. C., Iasevoli, F., & Ciccarelli, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02976-3 · Cited by 113 · see citing works
Prenatal infection, maternal immune activation, and risk for schizophrenia
Canetta, S., & Brown, A. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0045-6 · Cited by 109 · see citing works
DISC1 genetics, biology and psychiatric illness
Thomson, P. A., Malavasi, E. L. V., Grünewald, E., Soares, D. C., Borkowska, M., & Millar, J. K. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1254-7 · Cited by 109 · see citing works
Immune system gene dysregulation in autism and schizophrenia
Michel, M., Schmidt, M. J., & Mirnics, K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22044 · Cited by 107 · see citing works
Exposure to Prenatal Infection and Risk of Schizophrenia
Brown, A. S. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00063 · Cited by 105 · see citing works
Connor, C., Dincer, A., Straubhaar, J., Galler, J. R., Houston, I. B., & Akbarian, S. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.037 · Cited by 100 · see citing works
Guilarte, T. R., Opler, M. G., & Pletnikov, M. V. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2011.11.008 · Cited by 95 · see citing works
Self-citationMolecular substrates of schizophrenia: homeostatic signaling to connectivity
Landek‐Salgado, M. A., Faust, T. E., & Sawa, A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.141 · Cited by 93 · see citing works
Self-citationThe emerging tale of microglia in psychiatric disorders
Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 91 · see citing works
Immune Dysregulation in Autism Spectrum Disorder
Hsiao, E. Y. (2013) · International Review of Neurobiology · doi:10.1016/b978-0-12-418700-9.00009-5 · Cited by 87 · see citing works
Wu, W., Adams, C. E., Stevens, K. E., Chow, K.-H. K., Freedman, R., & Patterson, P. H. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.005 · Cited by 84 · see citing works
Fetal programming of schizophrenia: Select mechanisms
Debnath, M., Venkatasubramanian, G., & Berk, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.003 · Cited by 84 · see citing works
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
Samsom, J. N., & Wong, A. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00013 · Cited by 82 · see citing works
Woods, R. M., Lorusso, J. M., Fletcher, J., ElTaher, H., McEwan, F., Harris, I., Kowash, H. M., D'Souza, S. W., Harte, M., Hager, R., et al. (2023) · Neuronal Signaling · doi:10.1042/ns20220064 · Cited by 84 · see citing works
Animal models of gene–environment interaction in schizophrenia: A dimensional perspective
Ayhan, Y., McFarland, R., & Pletnikov, M. V. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.002 · Cited by 81 · see citing works
Self-citationStolp, H. B., Neuhaus, A. A., Sundramoorthi, R., & Molnár, Z. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00050 · Cited by 85 · see citing works
Ardalan, M., Chumak, T., Vexler, Z. S., & Mallard, C. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092270 · Cited by 79 · see citing works
Long-term pathological consequences of prenatal infection: beyond brain disorders
Labouesse, M. A., Langhans, W., & Meyer, U. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00087.2015 · Cited by 78 · see citing works
Guma, E., Bordignon, P. D. C., Devenyi, G. A., Gallino, D., Anastassiadis, C., Cvetkovska, V., Barry, A., Snook, E., Germann, J., Greenwood, C. M. T., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.03.017 · Cited by 75 · see citing works
Schwarz, J. M., & Bilbo, S. D. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.04.042 · Cited by 74 · see citing works
Immuno-psychiatry: an agenda for clinical practice and innovative research
Leboyer, M., Berk, M., Yolken, R. H., Tamouza, R., Kupfer, D. J., & Groc, L. (2016) · BMC Medicine · doi:10.1186/s12916-016-0712-5 · Cited by 73 · see citing works
Cell Biology of the BLOC-1 Complex Subunit Dysbindin, a Schizophrenia Susceptibility Gene
Mullin, A. P., Gokhale, A., Larimore, J. L., & Faúndez, V. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8183-3 · Cited by 72 · see citing works
Yee, N., Schwarting, R. K. W., Fuchs, E., & Wöhr, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.05.010 · Cited by 71 · see citing works
Neeley, E. W., Berger, R., Koenig, J. I., & Leonard, S. S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.065 · Cited by 71 · see citing works
Li, P. P., Sun, X., Xia, G., Arbez, N., Paul, S., Zhu, S., Peng, H. B., Ross, C. A., Koeppen, A. H., Margolis, R. L., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24761 · Cited by 70 · see citing works
Self-citationUtility and validity of DISC1 mouse models in biological psychiatry
Tomoda, T., Sumitomo, A., Jaaro-Peled, H., & Sawa, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.061 · Cited by 68 · see citing works
Self-citationRoles of glial cells in schizophrenia: Possible targets for therapeutic approaches
Takahashi, N., & Sakurai, T. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.001 · Cited by 67 · see citing works
Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment
Chini, M., Pöpplau, J. A., Lindemann, C., Carol-Perdiguer, L., Hnida, M., Oberlander, V. C., Xu, X., Ahlbeck, J., Bitzenhofer, S. H., Mulert, C., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.042 · Cited by 68 · see citing works
Toxoplasma Gondii and Cognitive Deficits in Schizophrenia: An Animal Model Perspective
Kannan, G., & Pletnikov, M. V. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs079 · Cited by 67 · see citing works
Self-citationAguilar-Valles, A., Rodrigue, B., & Matta-Camacho, E. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00852 · Cited by 62 · see citing works
Ordemann, J. M., & Austin, R. N. (2015) · Metallomics · doi:10.1039/c5mt00300h · Cited by 65 · see citing works
Bauman, M. D., & de Water, J. V. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104864 · Cited by 64 · see citing works
Yee, N., Ribic, A., de Roo, C. C., & Fuchs, E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.040 · Cited by 64 · see citing works
Inside the minds of mice and men
Baker, M. (2011) · Nature · doi:10.1038/475123a · Cited by 62 · see citing works
Needham, B. D., Tang, W., & Wu, W. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22581 · Cited by 59 · see citing works
DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice
Terrillion, C. E., Abazyan, B. N., Yang, Z., Crawford, J. A., Shevelkin, A. V., Jouroukhin, Y., Yoo, K. H., Cho, C. H., Roychaudhuri, R., Snyder, S. H., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.129 · Cited by 58 · see citing works
Self-citationIke, K. G. O., de Boer, S. F., Buwalda, B., & Kas, M. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.030 · Cited by 61 · see citing works
Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse models
Lipina, T. V., & Roder, J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.001 · Cited by 57 · see citing works
Ducharme, G., Lowe, G. C., Goutagny, R., & Williams, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029754 · Cited by 56 · see citing works
Jouroukhin, Y., Zhu, X., Shevelkin, A. V., Hasegawa, Y., Abazyan, B. N., Saito, A., Pevsner, J., Kamiya, A., & Pletnikov, M. V. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.07.024 · Cited by 53 · see citing works
Self-citationComplement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia
Severance, E. G., Gressitt, K. L., Halling, M., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Alaedini, A., Dupont, D., Dickerson, F., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.07.005 · Cited by 53 · see citing works
Social defeat interacts with Disc1 mutations in the mouse to affect behavior
Haque, F. N., Lipina, T. V., Roder, J., & Wong, A. H. C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.037 · Cited by 53 · see citing works
TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology
Chen, C.-Y., Liu, H., & Hsueh, Y. (2016) · EMBO Reports · doi:10.15252/embr.201642586 · Cited by 53 · see citing works
Mouse models of gene-environment interactions in schizophrenia
Kannan, G., Sawa, A., & Pletnikov, M. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.05.012 · Cited by 59 · see citing works
Self-citationMaternal Immune Activation and Schizophrenia–Evidence for an Immune Priming Disorder
Choudhury, Z., & Lennox, B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.585742 · Cited by 52 · see citing works
Animal Models of Maternal Immune Activation in Depression Research
Ronovsky, M., Berger, S., Molz, B., Berger, A., & Pollak, D. D. (2015) · Current Neuropharmacology · doi:10.2174/1570159x14666151215095359 · Cited by 49 · see citing works
Hartung, H., Cichon, N. B., Feo, V. D., Riemann, S., Schildt, S., Lindemann, C., Mulert, C., Gogos, J. A., & Hanganu‐Opatz, I. L. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw274 · Cited by 47 · see citing works
Abazyan, B., Dziedzic, J., Hua, K., Abazyan, S., Yang, C., Mori, S., Pletnikov, M., & Guilarte, T. (2014) · Schizophrenia bulletin · doi:10.1093/schbul/sbt071 · Cited by 54 · see citing works
Self-citationDISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders
Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A. V., Andrabi, S. A., Prandovszky, E., Yolken, R. H., Dawson, V. L., Dawson, T. M., Aja, S. M., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0123-9 · Cited by 48 · see citing works
Self-citationMaternal immune activation generates anxiety in offspring: A translational meta-analysis
Quagliato, L. A., de Matos, U. M. A., & Nardi, A. E. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01361-3 · Cited by 47 · see citing works
Nagai, T., Kitahara, Y., Ibi, D., Nabeshima, T., Sawa, A., & Yamada, K. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.049 · Cited by 47 · see citing works
Self-citationDISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders
Cash-Padgett, T. V., & Jaaro-Peled, H. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00113 · Cited by 46 · see citing works
Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models
Moran, P. M., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J. L., & O’Tuathaigh, C. M. P. (2016) · Neural Plasticity · doi:10.1155/2016/2173748 · Cited by 46 · see citing works
Prenatal inflammation and risk for schizophrenia: A role for immune proteins in neurodevelopment
Allswede, D. M., & Cannon, T. D. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000317 · Cited by 45 · see citing works
DISC1 as a therapeutic target for mental illnesses
Hikida, T., Gamo, N. J., & Sawa, A. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.719879 · Cited by 43 · see citing works
Self-citation
- Authors
- Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., Cadet, J. L., Pardo, C., Mori, S., Kamiya, A., Vogel, M. W., Sawa, A., Ross, C. A., & Pletnikov, M. V.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Pletnikov, Mikhail V.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 68
- Issue
- 12
- Pages
- 1172-1181
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3026608
- OpenAlex
- W2068766837
- Cited by
- 255
- References
- 83
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 11 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 13 · 2016: 24 · 2015: 24 · 2014: 16 · 2013: 24 · 2012: 32
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health
- Cell Science Research Foundation
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- DISC1, gene-environment interaction, maternal immune activation, polyinosinic-polycytidylic acid, prenatal immune activation, schizophrenia, mood disorders, anxiety, depression-like behavior, social behavior, hypothalamic-pituitary-adrenal axis, serotonergic neurotransmission, lateral ventricle enlargement, amygdala, periaqueductal gray, glycogen synthase kinase-3β, inflammatory cytokines
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Animals, Animals, Newborn, Atrophy, Behavior, Animal, Brain, Carrier Proteins, Corticosterone, Disease Models, Animal, Female, Male, Mice, Mutant Strains, Mice, Transgenic, Microtubule-Associated Proteins, Nerve Tissue Proteins, Poly I-C, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Biogenic Monoamines, Cytokines, Mood Disorders, Glycogen Synthase Kinase 3, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Dendritic Spines, Cytokine Receptor gp130, Mice, GRB2 Adaptor Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
