Epigenetic regulation in the pathophysiology of Alzheimer's disease
Abstract
With the aging of the population, the growing incidence and prevalence of Alzheimer's disease (AD) increases the burden on individuals and society as a whole. To date, the pathophysiology of AD is not yet fully understood. Recent studies have suggested that epigenetic mechanisms may play a pivotal role in its course and development. The most frequently studied epigenetic mechanisms are DNA methylation and histone modifications, and investigations relevant to aging and AD are presented in this review. Various studies on human postmortem brain samples and peripheral leukocytes, as well as transgenic animal models and cell culture studies relevant to AD will be discussed. From those, it is clear that aging and AD are associated with epigenetic dysregulation at various levels. Moreover, data on e.g. twin studies in AD support the notion that epigenetic mechanisms mediate the risk for AD. Conversely, it is still not fully clear whether the observed epigenetic changes actually represent a cause or a consequence of the disease. This is mainly due to the fact that most clinical investigations on epigenetics in AD are conducted in samples of patients already in an advanced stage of the disease. Evidently, more research is needed in order to clarify the exact role of epigenetic regulation in the course and development of AD. Research on earlier stages of the disease could provide more insight into its underlying pathophysiology, possibly contributing to the establishment of early diagnosis and the development of more effective treatment strategies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Epigenetic mechanisms are proposed to play crucial roles in ageing and age-related neurodegeneration.
“Epigenetic mechanisms are furthermore proposed to play crucial roles in ageing and age-related neurodegeneration 18, 19.”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [18]
Cites
Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466 · see citing works
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325 · see citing works
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336 · see citing works
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works
Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440 · see citing works
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works
The complex language of chromatin regulation during transcription
Berger, S. L. (2007) · Nature · doi:10.1038/nature05915 · Cited by 2,768 · see citing works
Epigenetics: A landscape takes shape
Goldberg, A. D., Allis, C. D., & Bernstein, E. (2007) · Cell · doi:10.1016/j.cell.2007.02.006 · Cited by 2,466 · see citing works
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works
Linking DNA methylation and histone modification: patterns and paradigms
Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267 · see citing works
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works
Intracellular amyloid-β in Alzheimer's disease
LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857 · see citing works
Role of Genes and Environments for Explaining Alzheimer Disease
Gatz, M., Reynolds, C. A., Fratiglioni, L., Johansson, B., Mortimer, J. A., Berg, S., Fiske, A., & Pedersen, N. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.168 · Cited by 1,798 · see citing works
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
Ooi, S. K. T., Qiu, C., Bernstein, E., Li, K., Jia, D., Yang, Z., Erdjument‐Bromage, H., Tempst, P., Lin, S., Allis, C. D., et al. (2007) · Nature · doi:10.1038/nature05987 · Cited by 1,558 · see citing works
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295 · see citing works
The structure of DNA in the nucleosome core
Richmond, T. J., & Davey, C. A. (2003) · Nature · doi:10.1038/nature01595 · Cited by 1,287 · see citing works
Kalaria, R. N., Maestre, G. E., Arizaga, R., Friedland, R. P., Galasko, D., Hall, K., Luchsinger, J. A., Ogunniyi, A., Perry, E. K., Potocnik, F., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70169-8 · Cited by 1,233 · see citing works
Recovery of learning and memory is associated with chromatin remodelling
Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227 · see citing works
A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60
Cao, X., & Südhof, T. C. (2001) · Science · doi:10.1126/science.1058783 · Cited by 1,202 · see citing works
Methylation of tRNA Asp by the DNA Methyltransferase Homolog Dnmt2
Goll, M. G., Kirpekar, F., Maggert, K. A., Yoder, J. A., Hsieh, C., Zhang, X., Golic, K. G., Jacobsen, S. E., & Bestor, T. H. (2006) · Science · doi:10.1126/science.1120976 · Cited by 1,192 · see citing works
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Bu, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2620 · Cited by 1,168 · see citing works
Felsenfeld, G., & Groudine, M. T. (2003) · Nature · doi:10.1038/nature01411 · Cited by 1,153 · see citing works
Cummings, J. L. (2004) · New England Journal of Medicine · doi:10.1056/nejmra040223 · Cited by 1,152 · see citing works
Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074 · see citing works
Christensen, B. C., Houseman, E. A., Marsit, C. J., Zheng, S., Wrensch, M., Wiemels, J. L., Nelson, H. H., Karagas, M. R., Padbury, J. F., Bueno, R., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000602 · Cited by 1,062 · see citing works
The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation
Fuks, F., Hurd, P. J., Wolf, D., Nan, X., Bird, A. P., & Kouzarides, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210256200 · Cited by 994 · see citing works
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
Fuks, F., Burgers, W. A., Brehm, A., Hughes‐Davies, L., & Kouzarides, T. (2000) · Nature Genetics · doi:10.1038/71750 · Cited by 988 · see citing works
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938 · see citing works
Physical Activity, Diet, and Risk of Alzheimer Disease
Scarmeas, N. (2009) · JAMA · doi:10.1001/jama.2009.1144 · Cited by 916 · see citing works
Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912 · see citing works
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases
Selkoe, D. J. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1054 · Cited by 863 · see citing works
Burns, A., & Iliffe, S. (2009) · BMJ · doi:10.1136/bmj.b158 · Cited by 859 · see citing works
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
Oberdoerffer, P., Michan, S., McVay, M., Mostoslavsky, R., Vann, J., Park, S.-K., Hartlerode, A., Stegmuller, J., Hafner, A., Loerch, P., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.025 · Cited by 852 · see citing works
The amyloid hypothesis for Alzheimer’s disease: A critical reappraisal
Hardy, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06181.x · Cited by 814 · see citing works
Strategy for Investigating Interactions Between Measured Genes and Measured Environments
Moffitt, T. E., Caspi, A., & Rutter, M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.473 · Cited by 784 · see citing works
Rethinking how DNA methylation patterns are maintained
Jones, P. A., & Liang, G. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2651 · Cited by 767 · see citing works
van Os, J., Rutten, B. P., & Poulton, R. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn117 · Cited by 713 · see citing works
Self-citationEpigenetics and aging: the targets and the marks
Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690 · see citing works
Multiple roles of HDAC inhibition in neurodegenerative conditions
Chuang, D.-M., Leng, Y., Marinova, Z., Kim, H.-J., & Chiu, C.-T. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.06.002 · Cited by 676 · see citing works
Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health
Meaney, M. J., Moshe Szyf, A., & Seckl, J. R. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.05.003 · Cited by 660 · see citing works
DNA Methylation Decreases in Aging But Not in Immortal Cells
Wilson, V. L., & Jones, P. A. (1983) · Science · doi:10.1126/science.6844925 · Cited by 649 · see citing works
Epigenetic mechanisms that underpin metabolic and cardiovascular diseases
Gluckman, P. D., Hanson, M. A., Buklijas, T., Low, F. M., & Beedle, A. S. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.102 · Cited by 627 · see citing works
Glucocorticoids increase amyloid-β and tau pathology in a mouse model of alzheimer’s disease
Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., & LaFerla, F. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2797-06.2006 · Cited by 623 · see citing works
Decline in genomic DNA methylation through aging in a cohort of elderly subjects
Bollati, V., Schwartz, J. D., Wright, R. O., Litonjua, A. A., Tarantini, L., Suh, H. H., Sparrow, D., Vokonas, P., & Baccarelli, A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.003 · Cited by 594 · see citing works
Tissue-specific regulation of SIRT1 by calorie restriction
Chen, D., Bruno, J., Easlon, E., Lin, S.-J., Cheng, H.-L., Alt, F. W., & Guarente, L. (2008) · Genes & Development · doi:10.1101/gad.1650608 · Cited by 567 · see citing works
Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
Small, S. A., & Duff, K. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.007 · Cited by 546 · see citing works
Modrego, P. J., & Ferrández, J. (2004) · Archives of Neurology · doi:10.1001/archneur.61.8.1290 · Cited by 539 · see citing works
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replicationPreprint
Estève, P., Chin, H. G., Smallwood, A., Feehery, G. R., Gangisetty, O., Karpf, A. R., Carey, M., & Pradhan, S. (2006) · Genes & Development · doi:10.1101/gad.1463706 · Cited by 539 · see citing works
The Colorful History of Active DNA Demethylation
Ooi, S. K. T., & Bestor, T. H. (2008) · Cell · doi:10.1016/j.cell.2008.06.009 · Cited by 537 · see citing works
The social environment and the epigenome
Moshe Szyf, A., McGowan, P. O., & Meaney, M. J. (2007) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20357 · Cited by 533 · see citing works
Genomic 5-methyldeoxycytidine decreases with age.
Wilson, V. L., Smith, R. A., Ma, S., & Cutler, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61057-9 · Cited by 521 · see citing works
Alzheimer's disease – do tauists and baptists finally shake hands?
Mudher, A. K., & Lovestone, S. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02031-2 · Cited by 512 · see citing works
Bannister, A. J., & Kouzarides, T. (2005) · Nature · doi:10.1038/nature04048 · Cited by 503 · see citing works
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
Abel, T. G., & Zukin, R. S. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.002 · Cited by 495 · see citing works
Sirtuin Functions in Health and Disease
Yamamoto, H., Schoonjans, K., & Auwerx, J. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0079 · Cited by 480 · see citing works
Wu, J., Basha, R. M., Brock, B., Cox, D. P., Cardozo‐Pelaez, F., McPherson, C. A., Harry, J., Rice, D. C., Maloney, B., Chen, D., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4405-07.2008 · Cited by 473 · see citing works
Tumours with PI3K activation are resistant to dietary restriction
Kalaany, N. Y., & Sabatini, D. M. (2009) · Nature · doi:10.1038/nature07782 · Cited by 468 · see citing works
Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease
Wang, S.-C., Oelze, B., & Schumacher, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002698 · Cited by 467 · see citing works
Clearance of Alzheimer's Aβ Peptide
Tanzi, R. E., Moir, R. D., & Wagner, S. L. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.024 · Cited by 431 · see citing works
Ricobaraza, A., Cuadrado-Tejedor, M., Pérez-Mediavilla, A., Frechilla, D., Del Río, J., & García-Osta, A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.229 · Cited by 423 · see citing works
A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis
Fede, G. D., Catania, M., Morbin, M., Rossi, G., Suardi, S., Mazzoleni, G., Merlin, M., Gıovagnolı, A. R., Prioni, S., Erbetta, A., et al. (2009) · Science · doi:10.1126/science.1168979 · Cited by 415 · see citing works
Siegmund, K. D., Connor, C., Campan, M., Long, T. I., Weisenberger, D. J., Biniszkiewicz, D., Jaenisch, R., Laird, P. W., & Akbarian, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000895 · Cited by 411 · see citing works
Green, K. N., Steffan, J. S., Martinez-Coria, H., Sun, X., Schreiber, S. S., Thompson, L. M., & LaFerla, F. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3203-08.2008 · Cited by 404 · see citing works
Histone deacetylase 6 interacts with the microtubule‐associated protein tau
Ding, H., Dolan, P. J., & Johnson, G. V. W. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05564.x · Cited by 387 · see citing works
Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation
Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C. M., Coleman, P. D., & Rogers, J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.12.005 · Cited by 386 · see citing works
Rapp, M. A., Beeri, M. S., Grossman, H. T., Sano, M. C., Perl, D. P., Purohit, D. P., Gorman, J. M., & Haroutunian, V. H. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.161 · Cited by 386 · see citing works
Genetic aspects of Alzheimer disease.
Bird, T. D. (2008) · Genetics in Medicine · doi:10.1097/gim.0b013e31816b64dc · Cited by 356 · see citing works
Epigenetics, oxidative stress, and Alzheimer disease
Zawia, N. H., Lahiri, D. K., & Cardozo-Pelaez, F. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.006 · Cited by 337 · see citing works
Relevance of DNA methylation in the management of cancer
Esteller, M. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01115-x · Cited by 329 · see citing works
The impact of metabolism on DNA methylation
Ulrey, C. L., Liu, L., Andrews, L. G., & Tollefsbol, T. O. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi100 · Cited by 317 · see citing works
Håkansson, K., Rovio, S., Helkala, E., Vilska, A.-R., Winblad, B., Soininen, H., Nissinen, A., Mohammed, A., & Kivipelto, M. (2009) · British medical journal · doi:10.1136/bmj.b2462 · Cited by 315 · see citing works
Epigenetic codes in cognition and behaviour
Gräff, J., & Mansuy, I. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.01.021 · Cited by 307 · see citing works
Critical loss of CBP/p300 histone acetylase activity by caspase‐6 during neurodegeneration
Rouaux, C., Jokic, N., Mbebi, C., Boutillier, S., Loeffler, J., & Boutillier, A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg615 · Cited by 302 · see citing works
Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease
Francis, Y. I., Fà, M., Ashraf, H., Zhang, H., Staniszewski, A., Latchman, D. S., & Arancio, O. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1134 · Cited by 296 · see citing works
Mastroeni, D., McKee, A. C., Grover, A., Rogers, J., & Coleman, P. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006617 · Cited by 292 · see citing works
Epigenetic principles and mechanisms underlying nervous system functions in health and disease
Mehler, M. F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.10.001 · Cited by 292 · see citing works
Huang, H.-C., & Jiang, Z.-F. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-0960 · Cited by 278 · see citing works
Gene-Environment Interactions and Epigenetic Basis of Human Diseases
Liu, L., Li, Y., & Tollefsbol, T. O. (2008) · Current Issues in Molecular Biology · doi:10.21775/cimb.010.025 · Cited by 273 · see citing works
Chronic Psychological Distress and Risk of Alzheimer’s Disease in Old Age
Wilson, R. S., Arnold, S. E., Schneider, J. A., Kelly, J. F., Tang, Y., & Bennett, D. A. (2006) · Neuroepidemiology · doi:10.1159/000095761 · Cited by 266 · see citing works
Maternal care, the epigenome and phenotypic differences in behavior
Moshe Szyf, A., Weaver, I. C. G., & Meaney, M. J. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.001 · Cited by 263 · see citing works
Early-Life Risk Factors for Alzheimer Disease
Borenstein, A. R., Copenhaver, C. I., & Mortimer, J. A. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000201854.62116.d7 · Cited by 259 · see citing works
Genomic organization of the human amyloid beta-protein precursor gene
Yoshikai, S.-I., Sasaki, H., Doh‐ura, K., Furuya, H., & Sakaki, Y. (1990) · Gene · doi:10.1016/0378-1119(90)90310-n · Cited by 259 · see citing works
Cross‐Talk between Aging and Cancer: The Epigenetic Language
FRAGA, M. F., AGRELO, R., & ESTELLER, M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.005 · Cited by 251 · see citing works
Prospects for epigenetic epidemiology
Foley, D. L., Craig, J. M., Morley, R., Olsson, C. J., Dwyer, T., Smith, K., & Saffery, R. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn380 · Cited by 244 · see citing works
Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders
Rutten, B. P. F., & Mill, J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp104 · Cited by 244 · see citing works
Self-citationWeaver, I. C. G. (2007) · Epigenetics · doi:10.4161/epi.2.1.3881 · Cited by 239 · see citing works
Progressive loss of SIRT1 with cell cycle withdrawal
Sasaki, T., Maier, B., Bartke, A., & Scrable, H. J. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00235.x · Cited by 235 · see citing works
Relationship between Helicobacter pylori infection and Alzheimer disease
Kountouras, J., Tsolaki, M., Gavalas, E., Boziki, M. K., Zavos, C., Karatzoglou, P., Chatzopoulos, D., & Venizelos, I. (2006) · Neurology · doi:10.1212/01.wnl.0000203644.68059.5f · Cited by 221 · see citing works
Abdolmaleky, H. M., Smith, C. L., Faraone, S. V., Shafa, R., Stone, W., Glatt, S. J., & Tsuang, M. T. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20142 · Cited by 216 · see citing works
The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases
Lahiri, D. K., Maloney, B., & Zawia, N. H. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.82 · Cited by 211 · see citing works
The Epigenetic Basis of Twin Discordance in Age-Related Diseases
Poulsen, P., Esteller, M., Vaag, A. A., & Fraga, M. F. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e31803c7b98 · Cited by 211 · see citing works
Complex disease, gender and epigenetics
Kaminsky, Z. A., Wang, S., & Petronis, A. (2006) · Annals of Medicine · doi:10.1080/07853890600989211 · Cited by 209 · see citing works
Hypomethylation of the amyloid precursor protein gene in the brain of an alzheimer’s disease patient
West, R. L., Lee, J. M., & Maroun, L. E. (1995) · Journal of Molecular Neuroscience · doi:10.1007/bf02736773 · Cited by 208 · see citing works
The Role of Heredity in Late-Onset Alzheimer Disease and Vascular Dementia
Bergem, A. L. M. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830150090013 · Cited by 208 · see citing works
Presenilin 1 gene silencing by S ‐adenosylmethionine: a treatment for Alzheimer disease?
Scarpa, S., Fuso, A., D’Anselmi, F., & Cavallaro, R. A. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00277-1 · Cited by 195 · see citing works
Epigenetics and twins: three variations on the theme
Petronis, A. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.04.010 · Cited by 193 · see citing works
Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease
Kountouras, J., Boziki, M. K., Gavalas, E., Zavos, C., Grigoriadis, N., Deretzi, G., Tzilves, D., Katsinelos, P., Tsolaki, M., Chatzopoulos, D., et al. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5011-z · Cited by 190 · see citing works
DNA Methylation of Alzheimer Disease and Tauopathy-Related Genes in Postmortem Brain
Barrachina, M., & Ferrer, I. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181af2e46 · Cited by 188 · see citing works
Lahiri, D. K., Farlow, M. R., Sambamurti, K., Greig, N. H., Giacobini, E., & Schneider, L. S. S. (2003) · Current Drug Targets · doi:10.2174/1389450033346957 · Cited by 185 · see citing works
Tau – an inhibitor of deacetylase HDAC6 function
Perez, M., Santa‐Maria, I., De Barreda, E. G., Zhu, X., Cuadros, R., Cabrero, J. R., Sanchez‐Madrid, F., Dawson, H. N., Vitek, M. P., Perry, G., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06102.x · Cited by 182 · see citing works
Tohgi, H., Utsugisawa, K., Nagane, Y., Yoshimura, M., Genda, Y., & Ukitsu, M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00163-1 · Cited by 181 · see citing works
Increased Neurofibrillary Tangles in Patients With Alzheimer Disease With Comorbid Depression
Rapp, M. A., Beeri, M. S., Purohit, D. P., Perl, D. P., Haroutunian, V. H., & Sano, M. C. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31816029ec · Cited by 178 · see citing works
Breitner, J. C. S. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540320035011 · Cited by 178 · see citing works
Belyaev, N. D., Nalivaeva, N. N., Makova, N. Z., & Turner, A. J. (2008) · EMBO Reports · doi:10.1038/embor.2008.222 · Cited by 177 · see citing works
Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
Gatz, M., Fratiglioni, L., Johansson, B. E. A., Berg, S., Mortimer, J. A., Reynolds, C. A., Fiske, A., & Pedersen, N. L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.04.004 · Cited by 177 · see citing works
Pfister, J. A., Ma, C., Morrison, B. E., & D’Mello, S. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004090 · Cited by 176 · see citing works
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes
Myung, N.-H., Zhu, X., Kruman, I. I., Castellani, R. J., Petersen, R. B., Siedlak, S. L., Perry, G., Smith, M. A., & Lee, H.-G. (2008) · AGE · doi:10.1007/s11357-008-9050-7 · Cited by 170 · see citing works
Adiposity and Alzheimer's disease
Luchsinger, J. A., & Gustafson, D. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831c8c71 · Cited by 169 · see citing works
Role of DNA Methylation in Stable Gene Repression
Lande‐Diner, L., Zhang, J., Ben‐Porath, I., Amariglio, N., Keshet, I., Hecht, M., Azuara, V., Fisher, A. G., Rechavi, G., & Cedar, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607838200 · Cited by 161 · see citing works
Epigenetic inheritance in mammals: Evidence for the impact of adverse environmental effects
Franklin, T. B., & Mansuy, I. M. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.012 · Cited by 153 · see citing works
Neuronal protection by sirtuins in Alzheimer's disease
Anekonda, T. S., & Reddy, P. H. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03492.x · Cited by 150 · see citing works
Chen, K.-L., Wang, S. S., Yang, Y.-Y., Yuan, R.-Y., Chen, R.-M., & Hu, C.-J. (2009) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2008.10.173 · Cited by 144 · see citing works
Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?
Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.021 · Cited by 139 · see citing works
Self-citationKennedy, B. P., Bottiglieri, T., Arning, E., Ziegler, M. G., Hansen, L. A., & Masliah, E. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0096-5 · Cited by 138 · see citing works
Lahiri, D. K., Maloney, B., Basha, R. M., Ge, Y. W., & Zawia, N. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362164 · Cited by 134 · see citing works
Lahiri, D. K., Sambamurti, K., & Bennett, D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.024 · Cited by 130 · see citing works
Developmental and vascular risk factors for Alzheimer's disease
Borenstein, A. R., Wu, Y., Mortimer, J. A., Schellenberg, G. D., McCormick, W. C., Bowen, J. D., McCurry, S. M., & Larson, E. B. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.04.010 · Cited by 125 · see citing works
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works
Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency
Fuso, A., Nicolia, V., Pasqualato, A., Fiorenza, M. T., Cavallaro, R. A., & Scarpa, S. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.02.013 · Cited by 124 · see citing works
Genetic Factors in Alzheimer's Disease
Bird, T. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmp058027 · Cited by 122 · see citing works
Law, I. K. M., Liu, L., Xu, A., Lam, K. S. L., Vanhoutte, P. M., Che, C., Leung, P. T. Y., & Wang, Y. (2009) · PROTEOMICS · doi:10.1002/pmic.200800738 · Cited by 115 · see citing works
Genetic and epigenetic regulation of aging
Fraga, M. F. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.04.003 · Cited by 112 · see citing works
Neuropathology of Alzheimer's disease and other dementias
Dickson, D. W. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70066-5 · Cited by 110 · see citing works
Clearance of Alzheimer's Aβ PeptideThe Many Roads to Perdition
Tanzi, R. E., Moir, R. D., & Wagner, S. L. (2004) · Neuron · doi:10.1016/s0896-6273(04)00533-1 · Cited by 107 · see citing works
Cholesterol and APOE genotype interact to influence Alzheimer disease progression
Evans, R. M., Hui, S. L., Perkins, A. J., Lahiri, D. K., Poirier, J., & Farlow, M. R. (2004) · Neurology · doi:10.1212/01.wnl.0000125323.15458.3f · Cited by 95 · see citing works
One-carbon metabolism in psychiatric illness
Sugden, C. (2006) · Nutrition Research Reviews · doi:10.1079/nrr2006119 · Cited by 91 · see citing works
Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits
Nakagawa, Y., Reed, L., Nakamura, M., McIntosh, T. K., Smith, D. H., Saatman, K. E., Raghupathi, R., Clemens, J., Saido, T. C., Lee, V. M.-Y., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7375 · Cited by 91 · see citing works
Silva, P. N., Gigek, C. O., Leal, M. F., Bertolucci, P. H. F., de Lábio, R. W., Payão, S. L. M., & Smith, M. D. A. C. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13207 · Cited by 86 · see citing works
Gene silencing through methylation: An epigenetic intervention on Alzheimer disease
Scarpa, S., Cavallaro, R. A., D’Anselmi, F., & Fuso, A. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9406 · Cited by 84 · see citing works
Variability of Familial Risk of Alzheimer Disease Across the Late Life Span
Silverman, J. M., Ciresi, G., Smith, C. J., Marin, D. B., & Beeri, M. S. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.565 · Cited by 80 · see citing works
4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease
Drake, J., Petroze, R. T., Castegna, A., Ding, Q., Keller, J. N., Markesbery, W. R., Lovell, M. A., & Butterfield, D. A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.047 · Cited by 77 · see citing works
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
Chen, D., Steele, A. D., Hütter, G., Bruno, J., Govindarajan, A., Easlon, E. J., Lin, S.-J., Aguzzi, A., Lindquist, S. L., & Guarente, L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.08.050 · Cited by 71 · see citing works
Zhang, Z., Zhang, Z., Fauser, U., & Schluesener, H. J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.061 · Cited by 71 · see citing works
Tohgi, H., Utsugisawa, K., Nagane, Y., Yoshimura, M., Ukitsu, M., & Genda, Y. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00731-4 · Cited by 70 · see citing works
Gene expression profile analysis of lymphocytes from Alzheimer??s patients
K??lm??n, J., Kitajka, K., ski, M. P. K., Zvara, ?., sz, A. J. A., Vincze, G., Janka, Z., & Pusk??s, L. G. (2005) · Psychiatric Genetics · doi:10.1097/00041444-200503000-00001 · Cited by 67 · see citing works
Evidence for parent of origin effect in late-onset Alzheimer disease
Bassett, S. S., Avramopoulos, D., & Fallin, D. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10648 · Cited by 66 · see citing works
Harold, D. H., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng1009-1156d · Cited by 64 · see citing works
Early-life events may trigger biochemical pathways for Alzheimer’s disease: the “LEARn” model
Lahiri, D. K., Zawia, N. H., Greig, N. H., Sambamurti, K., & Maloney, B. (2008) · Biogerontology · doi:10.1007/s10522-008-9162-6 · Cited by 62 · see citing works
Lin, H., Hsieh, H.-M., Chen, Y.-H., & Hu, M. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.03.011 · Cited by 62 · see citing works
Fuso, A., Cavallaro, R. A., Zampelli, A., D’Anselmi, F., Piscopo, P., Confaloni, A., & Scarpa, S. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11303 · Cited by 61 · see citing works
El‐Maarri, O., Kareta, M. S., Mikeska, T., Becker, T., Diaz-Lacava, A. N., Junen, J., Nüsgen, N., Behne, F., Wienker, T. F., Waha, A., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp088 · Cited by 54 · see citing works
Schizophrenia aetiology: Do gene-environment interactions hold the key?
The European Network of Schizophrenia Networks for the Study of Gene-Environment Interactions(EU-GEI) (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.003 · Cited by 52 · see citing works
Epigenetics of Complex Diseases: From General Theory to Laboratory Experiments
Schumacher, A., & Petronis, A. (2006) · Springer eBooks · doi:10.1007/3-540-31181-5_6 · Cited by 50 · see citing works
Gene-Environment-Wide Interaction Studies in Psychiatry
van Os, J., & Rutten, B. P. F. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.09060904 · Cited by 50 · see citing works
Self-citationDepression in the Prodromal Phase of Alzheimer Disease and the Reverse Causal Hypothesis
Modrego, P. J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.502 · Cited by 47 · see citing works
Brickell, K. L., Leverenz, J. B., Steinbart, E. J., Rumbaugh, M. C., Schellenberg, G. D., Nochlin, D., Lampe, T. H., Holm, I. E., Deerlin, V. M. V., Yuan, W., et al. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.113803 · Cited by 43 · see citing works
Traumatic brain injury induces relocalization of DNA-methyltransferase 1
Lundberg, J., Karimi, M., von Gertten, C., et al. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.105 · Cited by 43 · see citing works
Association of Decreased Paternal Age and Late-Onset Alzheimer's Disease
Farrer, L. A. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530180051017 · Cited by 40 · see citing works
Mani, S. T., & Thakur, M. K. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.006 · Cited by 39 · see citing works
Epigenetics, genomic mutations and cognitive function
Reichenberg, A., Mill, J. S., & MacCabe, J. H. (2009) · Cognitive Neuropsychiatry · doi:10.1080/13546800902978417 · Cited by 39 · see citing works
Schizophrenia aetiology: do gene-environment interactions hold the key?
Leboyer, M., Meyer‐Lindenberg, A., Stefanis, N. C., Rutten, B. P. F., Arango, C., Jones, P. B., Kapur, S., Lewis, S. W., Murray, R. M., Owen, M. J., et al. (2008) · Schizophrenia Research · Cited by 37 · see citing works
Self-citationThe effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis
Cavallaro, R. A., Fuso, A., D’Anselmi, F., Seminara, L., & Scarpa, S. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9407 · Cited by 20 · see citing works
Sweatt, J. D. (2007) · Nature · doi:10.1038/nature05716 · Cited by 20 · see citing works
Analysis of DNA variations in promoter region of HCNP gene with Alzheimer’s disease
Okita, K., Matsukawa, N., Maki, M., Nakazawa, H., Katada, E., Hattori, M., Akatsu, H., Borlongan, C. V., & Ojika, K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.037 · Cited by 17 · see citing works
P3‐260: Epigenetic modification in a monozygotic twin with Alzheimer's disease
Ryu, H., Barrup, M., Kowall, N. W., & McKee, A. C. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.1828 · Cited by 16 · see citing works
P2‐146: Epigenetic changes related to beta‐amyloid‐implications for Alzheimer's disease
Lithner, C. U., Hernandez, C. M., Nordberg, A. K., & Sweatt, J. D. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.457 · Cited by 16 · see citing works
Can the rDNA methylation pattern be used as a marker for Alzheimer's disease?
Sperança, M. A., Batista, L. M., Lourenço, R. D. S., et al. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.03.010 · Cited by 12 · see citing works
DNA methylation, ageing and ribosomal genes activity
de Carvalho, C. V., Sl, P., & Smith, M. D. A. C. (2000) · Biogerontology · doi:10.1023/a:1026542618182 · Cited by 10 · see citing works
Brunet, A. (2009) · Nature · doi:10.1038/458713a · Cited by 8 · see citing works
Räihä, I. J., Kaprio, J. A., Koskenvuo, M., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91543-3 · Cited by 5 · see citing works
Zukin, S. R. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.502 · Cited by 3 · see citing works
Nakagawa (1999) · doi:10.1002/(sici)1096-9861(19990830)411:3
Flagged first, then by citations
Cited by
Sorted by citations
Alzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works
Resilience in mental health: linking psychological and neurobiological perspectives.
Rutten, B. P. F., Hammels, C., Geschwind, N., Menne‐Lothmann, C., Pishva, E., Schruers, K., van den Hove, D., Kenis, G., van Os, J., & Wichers, M. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12095 · Cited by 418 · see citing works
Self-citationThe epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works
Self-citationGenetics of familial and sporadic Alzheimer s disease
Piaceri, I. (2013) · Frontiers in Bioscience · doi:10.2741/e605 · Cited by 256 · see citing works
MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease
Denk, J., Boelmans, K., Siegismund, C., Lassner, D., Arlt, S., & Jahn, H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126423 · Cited by 236 · see citing works
Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease
Pietrzak, M., Rempala, G., Nelson, P. T., Zheng, J.-J., & Hetman, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022585 · Cited by 155 · see citing works
Griñán-Ferré, C., Izquierdo, V., Otero, E., Puigoriol-Illamola, D., Corpas, R., Sanfeliu, C., Ortuño-Sahagún, D., & Pallàs, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00224 · Cited by 94 · see citing works
Chouliaras, L., L.A. van den Hove, D., Kenis, G., Keitel, S., R. Hof, P., van Os, J., W.M. Steinbusch, H., Schmitz, C., & P.F. Rutten, B. (2012) · Current Alzheimer Research · doi:10.2174/156720512800618035 · Cited by 91 · see citing works
Self-citationCaloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus
Chouliaras, L., van den Hove, D. L. A., Kenis, G., Dela Cruz, J., Lemmens, M. A. M., van Os, J., Steinbusch, H. W. M., Schmitz, C., & Rutten, B. P. F. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.11.016 · Cited by 89 · see citing works
Self-citationPrevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction
Chouliaras, L., van den Hove, D. L. A., Kenis, G., Keitel, S., Hof, P. R., van Os, J., Steinbusch, H. W. M., Schmitz, C., & Rutten, B. P. F. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.003 · Cited by 78 · see citing works
Self-citationAging alters mRNA expression of amyloid transporter genes at the blood-brain barrier
Osgood, D., Miller, M. C., Messier, A. A., Gonzalez, L., & Silverberg, G. D. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.011 · Cited by 63 · see citing works
- Authors
- Chouliaras, L., Rutten, B. P. F., Kenis, G., Peerbooms, O., Visser, P. J., Verhey, F., van Os, J., Steinbusch, H. W. M., & van den Hove, D. L. A.
- Affiliations
- Maastricht University Medical Centre (NL)
- Corresponding author
- Rutten, Bart P.F.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 90
- Issue
- 4
- Pages
- 498-510
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2146824244
- Cited by
- 262
- References
- 167
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 14 · 2018: 14 · 2017: 9 · 2016: 13 · 2015: 26 · 2014: 21 · 2013: 32 · 2012: 35
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, epigenetic regulation, DNA methylation, histone modifications, aging, epigenetic dysregulation, postmortem brain, peripheral blood leukocytes, transgenic animal models, twin studies, disease risk, early diagnosis, pathophysiology
- MeSH terms
- Aging, Alzheimer Disease, Animals, Environment, Gene Expression Regulation, Histones, Humans, DNA Methylation, Genetic Predisposition to Disease, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review