Cited by 262Alzheimer's disease research and treatmentsEpigenetics and DNA MethylationDementia and Cognitive Impairment Research

Epigenetic regulation in the pathophysiology of Alzheimer's disease

Chouliaras, Leonidas, Rutten, Bart P.F., Kenis, Gunter, Peerbooms, Odette, Visser, Pieter Jelle, Verhey, Frans, van Os, Jim, Steinbusch, Harry W.M. +1 more·2010·Progress in Neurobiology

Abstract

With the aging of the population, the growing incidence and prevalence of Alzheimer's disease (AD) increases the burden on individuals and society as a whole. To date, the pathophysiology of AD is not yet fully understood. Recent studies have suggested that epigenetic mechanisms may play a pivotal role in its course and development. The most frequently studied epigenetic mechanisms are DNA methylation and histone modifications, and investigations relevant to aging and AD are presented in this review. Various studies on human postmortem brain samples and peripheral leukocytes, as well as transgenic animal models and cell culture studies relevant to AD will be discussed. From those, it is clear that aging and AD are associated with epigenetic dysregulation at various levels. Moreover, data on e.g. twin studies in AD support the notion that epigenetic mechanisms mediate the risk for AD. Conversely, it is still not fully clear whether the observed epigenetic changes actually represent a cause or a consequence of the disease. This is mainly due to the fact that most clinical investigations on epigenetics in AD are conducted in samples of patients already in an advanced stage of the disease. Evidently, more research is needed in order to clarify the exact role of epigenetic regulation in the course and development of AD. Research on earlier stages of the disease could provide more insight into its underlying pathophysiology, possibly contributing to the establishment of early diagnosis and the development of more effective treatment strategies.

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Crossref · 10.1016/j.pneurobio.2010.01.002

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Authors
Chouliaras, L., Rutten, B. P. F., Kenis, G., Peerbooms, O., Visser, P. J., Verhey, F., van Os, J., Steinbusch, H. W. M., & van den Hove, D. L. A.
Affiliations
Maastricht University Medical Centre (NL)
Corresponding author
Rutten, Bart P.F.
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2010-04
Volume
90
Issue
4
Pages
498-510
ISSN
0301-0082 (ISSN-L)
OpenAlex
W2146824244
Cited by
262
References
167
Citations by year
2026: 5 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 14 · 2018: 14 · 2017: 9 · 2016: 13 · 2015: 26 · 2014: 21 · 2013: 32 · 2012: 35
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, epigenetic regulation, DNA methylation, histone modifications, aging, epigenetic dysregulation, postmortem brain, peripheral blood leukocytes, transgenic animal models, twin studies, disease risk, early diagnosis, pathophysiology
MeSH terms
Aging, Alzheimer Disease, Animals, Environment, Gene Expression Regulation, Histones, Humans, DNA Methylation, Genetic Predisposition to Disease, Epigenesis, Genetic

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