Neurobiological effects of physical exercise in schizophrenia: a systematic review.
Abstract
PURPOSE: The aim of the present systematic review was to provide a summary of neurobiological effects of physical exercise for people with schizophrenia. METHODS: A systematic review was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Searches were conducted up to April 2013 across three databases: Medline, PsycINFO, and Embase. A methodological quality assessment using the Downs and Black Quality Index was carried out with all of the included studies. RESULTS: Of the 654 initial data search results, two studies reported in 3 articles including 48 patients (six women) with schizophrenia, met the eligibility criteria. The methodological quality of each study was high. Data on hippocampal volume changes following physical exercise were conflicting while physical exercise-induced changes in other brain areas were absent. Increases in hippocampal volume following physical exercise were correlated with improvements in aerobic fitness and short-term memory. CONCLUSIONS: Future research is needed to investigate whether brain health in people with schizophrenia is activity-dependent. Additionally, research that considers the neurobiological mechanisms and associated functional outcomes of physical exercise in individuals with schizophrenia is required. IMPLICATIONS FOR REHABILITATION: Understanding the neurobiological effects of physical exercise in patients with schizophrenia may contribute to the development of new rehabilitation strategies. There is currently insufficient evidence to determine if physical exercise has a beneficial influence on the brain health of people with schizophrenia.
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AE is known to be preventative of cardiovascular, metabolic and respiratory dysfunction.
“Moreover, AE is known to be preventative of cardiovascular, metabolic and respiratory dysfunction, which suggests that the inclusion of an AE intervention may be useful in stemming the risk of psychiatric patients developing these severe conditions (Caemmerer et al., 2012; Vancampfort et al., 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Vancampfort et al., 2014
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Aerobic and Postural Strength Exercise Benefits in People with Schizophrenia
Szortyka, M. F., Cristiano, V. B., & Belmonte-de-Abreu, P. S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043421 · Cited by 6 · see citing works
Yoga versus non-standard care for schizophrenia
Broderick, J. M., Crumlish, N., Waugh, A., & Vancampfort, D. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012052 · Cited by 6 · see citing works
Cotterill, M., & Kotera, Y. (2023) · International Journal of Spa and Wellness · doi:10.1080/24721735.2023.2229711 · Cited by 4 · see citing works
Sporttherapie bei schizophrenen Psychosen: Von der Idee bis zur Leitlinie
Falkai, P., Schwaiger, R., Schmitt, A., Röll, L., & Maurus, I. (2023) · Das Gesundheitswesen · doi:10.1055/a-2129-7421 · Cited by 4 · see citing works
Pilates-Based Training for Postural Stability in Patients with Schizophrenia
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Nörobilim Ve Psikiyatri Hemşireliğinde Kullanımı: Hayal Ya Da Gerçek?
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- Authors
- Vancampfort, D., Probst, M., De Hert, M., Soundy, A., Stubbs, B., Stroobants, M., & De Herdt, A.
- Affiliations
- KU Leuven (BE)
- University of Birmingham (GB)
- University of Greenwich (GB)
- Corresponding author
- Vancampfort, Davy
- Venue
- Disability and Rehabilitation
- Publisher
- Informa UK Limited
- Published
- 2014-01-02
- Volume
- 36
- Issue
- 21
- Pages
- 1749-1754
- ISSN
- 0963-8288 (ISSN-L)
- 1464-5165
- OpenAlex
- W2063699516
- Cited by
- 80
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 15 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 13 · 2014: 3 · 2013: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Disability and Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Greenwich Academic Literature Archive (University of Greenwich) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Lirias (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- physical activity, schizophrenia, neurobiological effects, hippocampal volume, cardiorespiratory fitness, short-term memory, brain health, rehabilitation strategies
- MeSH terms
- Hippocampus, Humans, Organ Size, Schizophrenia, Exercise
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