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Quantitative Meta-Analysis on State and Trait Aspects of Auditory Verbal Hallucinations in Schizophrenia
Open accessAbstract
Auditory verbal hallucinations (AVHs) have a high prevalence in schizophrenic patients. An array of studies have explored the neural correlates of AVHs by means of functional neuroimaging and have associated AVHs with diverse brain regions, some of which have been shown to be involved in speech generation, speech perception, and auditory stimulus processing. We divided these studies into "state" studies comparing periods of presence and absence of AVHs within-subject and "trait" studies comparing patients experiencing AVHs with patients without AVHs or healthy controls during tasks with verbal material. We set out to test the internal consistency and possible dissociations of the neural correlates of AVHs. We used activation likelihood estimation to perform quantitative meta-analyses on brain regions reported in state and trait studies on AVHs to assess significant concordance across studies. State studies were associated with activation in bilateral inferior frontal gyrus, bilateral postcentral gyrus, and left parietal operculum. Trait studies on the other hand showed convergence of decreases in hallucinating subjects in left superior temporal gyrus, left middle temporal gyrus, anterior cingulate cortex, and left premotor cortex activity. Based on the clear dissociation of brain regions that show convergence across state in comparison to trait studies, we conclude that the state of experiencing AVHs is primarily related brain regions that have been implicated in speech production ie, Broca's area, whereas the general trait that makes humans prone to AVHs seems to be related to brain areas involved in auditory stimuli processing and speech perception, ie, auditory cortex.
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“Our present study extends this by showing commonalities between many of the neural regions activated during AVH (such as left STG, left insula, left IFG) and those strongly activated during dialogic inner speech (Jardri et al., 2011; Kühn and Gallinat, 2012).”
From The brain's conversation with itself: neural substrates of dialogic inner speech (2016) · cites this paper as Kühn and Gallinat, 2012
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“Recent meta-analyses of symptom-capture studies have come to only partially overlapping conclusions: while Jardri et al. (2011) found AVHs to be associated with activation in left IFG, anterior insula, superior temporal, and hippocampal areas, Kühn and Gallinat (2012) could only find consistent results for bilateral IFG, postcentral gyrus, and parietal areas.”
From Inner Speech: Development, Cognitive Functions, Phenomenology, and Neurobiology (2015) · cites this paper as Kühn and Gallinat (2012)
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Cited by
Sorted by citations
Inner Speech: Development, Cognitive Functions, Phenomenology, and Neurobiology
Alderson-Day, B., & Fernyhough, C. (2015) · Psychological Bulletin · doi:10.1037/bul0000021 · Cited by 864
“…studies (investigating neural correlates of the occurrence of AVHs in the scanner) show activation of inferior frontal gyrus bilaterally (Kühn & Gallinat, 2012), while speech-processing atypicalities in schizophrenia patients who experience AVHs are also consistent with a model in…”
ResultThe neural mechanisms of hallucinations: A quantitative meta-analysis of neuroimaging studies
Zmigrod, L., Garrison, J. R., Carr, J., & Simons, J. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.037 · Cited by 226
Interaction of language, auditory and memory brain networks in auditory verbal hallucinations
Ćurčić-Blake, B., Ford, J. M., Hubl, D., Orlov, N. D., Sommer, I. E., Waters, F., Allen, P., Jardri, R., Woodruff, P. W., David, O., et al. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.11.002 · Cited by 224
“The STG (left and right) are almost universally active during AVH (Jardri et al., 2011; Kuhn and Gallinat, 2010).”
BackgroundKompus, K., Westerhausen, R., & Hugdahl, K. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.08.010 · Cited by 286
The auditory steady-state response (ASSR)
O’Donnell, B. F., Vohs, J. L., Krishnan, G. P., Rass, O., Hetrick, W. P., & Morzorati, S. L. (2013) · Supplements to Clinical neurophysiology · doi:10.1016/b978-0-7020-5307-8.00006-5 · Cited by 182
“Auditory hallucinations are a diagnostic criterion for SZ, and patients with auditory hallucinations show altered brain activation in left superior temporal gyrus and middle temporal gyrus compared to nonhallucinating individuals (Kuhn and Gallinat, 2010).”
Background
Metadata
- Authors
- Kuhn, S., & Gallinat, J.
- Affiliations
- St. Hedwig-Krankenhaus (DE)
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12-22
- Volume
- 38
- Issue
- 4
- Pages
- 779-786
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC3406531
- OpenAlex
- W2159319538
- Cited by
- 245
- References
- 53
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 77 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 12 · 2019: 10 · 2018: 9 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 8 · 2013: 12 · 2012: 13
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- Bundesministerium für Bildung und Forschung (01GS08159)
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Cilag
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- auditory verbal hallucinations, schizophrenia
- MeSH terms
- Auditory Perception, Brain, Frontal Lobe, Gyrus Cinguli, Hallucinations, Humans, Magnetic Resonance Imaging, Parietal Lobe, Schizophrenia, Speech Perception, Temporal Lobe, Positron-Emission Tomography, Functional Neuroimaging
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