Cited by 530Schizophrenia research and treatmentFunctional Brain Connectivity StudiesHallucinations in medical conditions

Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations

Lawrie, Stephen M, Buechel, Christian, Whalley, Heather C, Frith, Christopher D, Friston, Karl J, Johnstone, Eve C·2002·Biological Psychiatry

Abstract

Background We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia.Methods Eight DSM-IV schizophrenia patients and 10 control subjects were studied with fMRI while they thought of the missing last word in 128 visually presented sentences. The fMRI data were analyzed comparing the effect of sentence completion (vs. rest) using a random effects analysis.Results There were no significant group differences in regional brain responses. Correlation coefficients between left temporal cortex (x = -54, y = -42, z = 3) and left dorsolateral prefrontal cortex (x = -39, y = 12, z = 24) were significantly lower in the schizophrenic group and were negatively correlated with the severity of auditory hallucinations.Conclusions Previous demonstrations of hypofrontality in schizophrenia may reflect particular task requirements. Frontotemporal functional connectivity is reduced in schizophrenia and may be associated with auditory hallucinations.

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Crossref · 10.1016/s0006-3223(02)01316-1

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Authors
Lawrie, S. M., Buechel, C., Whalley, H. C., Frith, C. D., Friston, K. J., & Johnstone, E. C.
Affiliations
  • Royal Edinburgh Hospital (GB)
  • National Hospital for Neurology and Neurosurgery (GB)
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2002-06
Volume
51
Issue
12
Pages
1008-1011
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2029059267
Cited by
529
References
15
Citations by year
2026: 3 · 2025: 2 · 2024: 9 · 2023: 9 · 2022: 16 · 2021: 20 · 2020: 14 · 2019: 16 · 2018: 24 · 2017: 26 · 2016: 29 · 2015: 24 · 2014: 27 · 2013: 41 · 2012: 33
FWCI
14.50
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords
schizophrenia, auditory hallucinations, dorsolateral prefrontal cortex, left temporal cortex, hypofrontality, sentence completion task
MeSH terms
Adult, Female, Frontal Lobe, Hallucinations, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Task Performance and Analysis, Temporal Lobe

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