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Cited by 133Schizophrenia research and treatmentMental Health and PsychiatryNeurological disorders and treatments

Motor abnormalities: from neurodevelopmental to neurodegenerative through “functional” (neuro)psychiatric disorders

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Peralta, Victor, Cuesta, Manuel J·2017·Schizophrenia Bulletin
DOI 10.1093/schbul/sbx089PMC PMC5581892
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Abstract

Background: Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to a great extent on schizophrenia, and as a consequence their prevalence and featural properties in other psychiatric or neuropsychiatric disorders are poorly known. In this article, we evaluated the extent to which catatonic, extrapyramidal and neurological soft signs, and their associated clinical features, are present transdiagnostically. Methods: We examined motor-related features in neurodevelopmental (schizophrenia, obsessive compulsive disorder, autism spectrum disorders), "functional" (nonschizophrenic nonaffective psychoses, mood disorders) and neurodegenerative (Alzheimer's disease) disorders. Examination of the literature revealed that there have been very few comparisons of motor-related features across diagnoses and we had to rely mainly in disorder-specific studies to compare it transdiagnostically. Results: One or more motor domains had a substantial prevalence in all the diagnoses examined. In "functional" disorders, MAs, and particularly catatonic signs, appear to be markers of episode severity; in chronic disorders, although with different degree of strength or evidence, all motor domains are indicators of both disorder severity and poor outcome; lastly, in Alzheimer's disease they are also indicators of disorder progression. Conclusions: MAs appear to represent a true transdiagnostic domain putatively sharing neurobiological mechanisms of neurodevelopmental, functional or neurodegenerative origin.

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  • The National Institute for Mental Health (NIMH), in its Research Domain Criteria (RDoC) framework matrix, has recently proposed the incorporation of a new Sensorimotor Systems domain, composed of subconstructs such as Motor Actions, Agency and Ownership and Habits.

    “The National Institute for Mental Health (NIMH), in its Research Domain Criteria (RDoC) framework matrix [76 -79], has recently proposed the incorporation of a new Sensorimotor Systems domain, composed of sub­ constructs such as Motor Actions, Agency and Ownership and Habits [80 -82]”

    From Habit as a therapeutic component in psychological treatment for obsessive-compulsive disorder: A randomised controlled feasibility study. (2026) · cites this paper as [82]

    The Introduction says motor abnormalities had been proposed as a putative domain within the NIMH RDoC framework, and the Discussion argues they should be incorporated as an additional domain. Neither passage says NIMH recently proposed a Sensorimotor Systems domain or identifies Motor Actions, Agency and Ownership, and Habits as its subconstructs. (LLM, conf=0.82)

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Research works printed but not linked: 1

  1. [10]10. Steck H. Les syndromes extrapiramidaus dans les maladies mentales. Arch Suiss Neurol Psychiatr. 1926;19:195–233. [Google Scholar]

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Authors
Peralta, V., & Cuesta, M. J.
Affiliations
Complejo Hospitalario de Navarra (ES)
ORCID
Cuesta, Manuel J
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
2017-07-22
Volume
43
Issue
5
Pages
956-971
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/sbx089
PMC
PMC5581892
OpenAlex
W2737738292
Cited by
133
References
251
Citations by year
2026: 8 · 2025: 22 · 2024: 5 · 2023: 11 · 2022: 16 · 2021: 20 · 2020: 21 · 2019: 8 · 2018: 13 · 2017: 9
FWCI
2.12
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Instituto de Salud Carlos III (PI16/02148)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
motor abnormalities, transdiagnostic markers
MeSH terms
Autism Spectrum Disorder, Alzheimer Disease, Humans, Movement Disorders, Obsessive-Compulsive Disorder, Psychotic Disorders, Schizophrenia, Mood Disorders

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