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Sleep Homeostasis and Cortical Synchronization: II. A Local Field Potential Study of Sleep Slow Waves in the Rat
Open accessAbstract
STUDY OBJECTIVE: Sleep slow-wave activity (SWA, EEG power between 0.5 and 4.0 Hz) decreases homeostatically in the course of non-rapid eye movement sleep (NREM) sleep. According to a recent hypothesis, the homeostatic decrease of sleep SWA is due to a progressive decrease in the strength of corticocortical connections. This hypothesis was evaluated in a large-scale thalamocortical model, which showed that a decrease in synaptic strength, implemented through a reduction of postsynaptic currents, resulted in lower sleep SWA in simulated local field potentials (LFP). The decrease in SWA was associated with a decreased proportion of high-amplitude slow waves, a decreased slope of the slow waves, and an increase in the number of multipeak waves. Here we tested the model predictions by obtaining LFP recordings from the rat cerebral cortex and comparing conditions of high homeostatic sleep pressure (early sleep) and low homeostatic sleep pressure (late sleep). DESIGN: Intracortical LFP recordings during baseline sleep and after 6 hours of sleep deprivation. SETTING: Basic sleep research laboratory. PATIENTS OR PARTICIPANTS: WKY adult male rats. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Early sleep (sleep at the beginning of the major sleep phase, sleep immediately after sleep deprivation) was associated with (1) high SWA, (2) many large slow waves, (3) steep slope of slow waves, and (4) rare occurrence of multipeak waves. By contrast, late sleep (sleep at the end of the major sleep phase, sleep several hours after the end of sleep deprivation) was associated with (1) low SWA, (2) few high-amplitude slow waves, (3) reduced slope of slow waves, and (4) more frequent multipeak waves. CONCLUSION: In rats, changes in sleep SWA are associated with changes in the amplitude and slope of slow waves, and in the number of multi-peak waves. Such changes in slow-wave parameters are compatible with the hypothesis that average synaptic strength decreases in the course of sleep.
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“Specifically, the model predicted a decrease in the incidence of high-amplitude slow waves, a decrease in slope, as well as an increase in the number of multipeak waves from early to late sleep, which was con-firmed in related animal and human studies (994, 1269).”
From About Sleep's Role in Memory (2013) · cites this paper as [1269]
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“Recent evidence suggests that slow wave activity is also an indicator of synaptic strength in the brain (Esser et al., 2007; Riedner et al., 2007; Vyazovskiy et al., 2007).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Vyazovskiy et al., 2007
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Learning induces long-term potentiation in the hippocampus
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Research works printed but not linked: 1
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837
Cortical firing and sleep homeostasis
Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.024 · Cited by 740
Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks
Abel, T. G., Havekes, R., Saletin, J., & Walker, M. P. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.025 · Cited by 585
Metadata
- Authors
- Vyazovskiy, V. V., Riedner, B. A., Cirelli, C., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12
- Volume
- 30
- Issue
- 12
- Pages
- 1631-1642
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC2276140
- OpenAlex
- W2124761808
- Cited by
- 225
- References
- 68
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 14 · 2023: 15 · 2022: 11 · 2021: 12 · 2020: 11 · 2019: 13 · 2018: 14 · 2017: 16 · 2016: 16 · 2015: 10 · 2014: 19 · 2013: 18 · 2012: 6
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (106264)
- National Institutes of Health (NRSA T32)
- National Institute of General Medical Sciences (T32GM007507)
- National Institute of Diabetes and Digestive and Kidney Diseases (T90DK070079)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep homeostasis, sleep slow waves, cortical synchronization, synaptic efficacy, sleep deprivation, NREM sleep, thalamocortical model, local field potentials, corticocortical connections, rat cortex
- MeSH terms
- Animals, Cerebral Cortex, Circadian Rhythm, Computer Simulation, Cortical Synchronization, Electroencephalography, Evoked Potentials, Fourier Analysis, Homeostasis, Male, Nerve Net, Rats, Inbred WKY, Sleep, Sleep Deprivation, Thalamus, Rats
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