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Cited by 539Pain Mechanisms and TreatmentsSleep and Wakefulness ResearchSleep and Work-Related Fatigue

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The Effects of Sleep Deprivation on Pain Inhibition and Spontaneous Pain in Women

Smith, Michael T., Edwards, Robert R., McCann, Una D., Haythornthwaite, Jennifer A.·2007·Sleep
DOI 10.1093/sleep/30.4.494
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Abstract

Impaired central pain modulation is implicated in the pathophysiology of chronic pain. In this controlled experiment, we evaluated whether partial sleep loss altered endogenous pain inhibition and reports of spontaneous pain. Thirty-two healthy females were studied polysomnographically for 7 nights. On Nights 1-2 (Baseline), subjects slept undisturbed for 8 hours. After Night 2, subjects were randomized to Control (N = 12), Forced Awakening (FA, N = 10), or Restricted Sleep Opportunity (RSO, N = 10) conditions. Controls continued to sleep undisturbed. FA underwent 8 forced awakenings (one per hour) on Nights 3-5. RSO subjects were yoked to FA on total sleep time (TST), receiving partial sleep deprivation by delayed bedtime. On Night 6, both FA & RSO underwent 36 hours total sleep deprivation (TSD), followed by 11-hour recovery sleep (Night 7). Subjects completed twice-daily psychophysical assessments of mechanical pain thresholds and pain inhibition (Diffuse Noxious Inhibitory Controls), via use of a conditioning stimulus (i.e., cold pressor) paradigm. FA and RSO demonstrated 50% reductions in total sleep time and increases in nonpainful somatic symptoms during partial sleep deprivation. While sleep deprivation had no effect on pain thresholds, during partial sleep deprivation the FA group demonstrated a significant loss of pain inhibition and an increase in spontaneous pain; neither of the other 2 groups showed changes in pain inhibition or spontaneous pain during partial sleep deprivation. These data suggest that sleep continuity disturbance, but not simple sleep restriction, impairs endogenous pain-inhibitory function and increases spontaneous pain, supporting a possible pathophysiologic role of sleep disturbance in chronic pain.

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  1. Nielsen KD, Drewes AM, Svendsen L, Bjerregard K, Taagholt S. Ambulatory recording and power spectral analysis by autoregres- sive modeling of polygraphic sleep signals in patients suffering from chronic pain. Methods Inf Med 1994;33:76-8.
  2. Roizenblatt S, Moldofsky H, Benedito-Silva AA, Tufik S. Alpha sleep characteristics in fibromyalgia. Arthritis Rheum 2001;44:222-30.
  3. Perlis ML, Giles DE, Mendelson WB, Bootzin RR, Wyatt JK. Psy- chophysiological insomnia: the behavioural model and a neurocog- nitive perspective. J Sleep Res 1997;6:179-88.
  4. Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self- report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA 1999; 282:1737-44.
  5. Nakagawa S. A farewell to Bonferroni: the problems of low statisti- cal power and publication bias. Behav Ecol 2004;15:1044-5.

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Metadata

Authors
Smith, M. T., Edwards, R. R., McCann, U. D., & Haythornthwaite, J. A.
Affiliations
Johns Hopkins University (US)
Corresponding author
Smith, Michael T.
ORCID
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2007-04
Volume
30
Issue
4
Pages
494-505
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.1093/sleep/30.4.494
OpenAlex
W190565509
Cited by
539
References
54
Citations by year
2026: 24 · 2025: 27 · 2024: 18 · 2023: 40 · 2022: 42 · 2021: 32 · 2020: 24 · 2019: 37 · 2018: 27 · 2017: 23 · 2016: 19 · 2015: 34 · 2014: 32 · 2013: 32 · 2012: 37
FWCI
14.31
Type
journal article
Language
en
Open access
closed
Locations
  • SLEEP (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (K23 NS47168, R21NS051771, K23NS047168)
  • National Center for Research Resources (M01RR002719)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
sleep deprivation, pain inhibition, spontaneous pain, central pain modulation, chronic pain, sleep continuity, sleep restriction, mechanical pain threshold, diffuse noxious inhibitory control, cold pressor pain, women, recovery sleep
MeSH terms
Adult, Chronic Disease, Female, Humans, Neural Inhibition, Pain, Pain Measurement, Reference Values, Sick Role, Sleep Deprivation, Sleep Wake Disorders, Wakefulness, Polysomnography, Pain Threshold

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