Cited by 163Circadian rhythm and melatoninSleep and Work-Related FatigueImpact of Light on Environment and Health

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Individual differences in light sensitivity affect sleep and circadian rhythms

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Chellappa, Sarah L·2021·Sleep

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Abstract

Artificial lighting is omnipresent in contemporary society with disruptive consequences for human sleep and circadian rhythms because of overexposure to light, particularly in the evening/night hours. Recent evidence shows large individual variations in circadian photosensitivity, such as melatonin suppression, due to artificial light exposure. Despite the emerging body of research indicating that the effects of light on sleep and circadian rhythms vary dramatically across individuals, recommendations for appropriate light exposure in real-life settings rarely consider such individual effects. This review addresses recently identified links among individual traits, for example, age, sex, chronotype, genetic haplotypes, and the effects of evening/night light on sleep and circadian hallmarks, based on human laboratory and field studies. Target biological mechanisms for individual differences in light sensitivity include differences occurring within the retina and downstream, such as the central circadian clock. This review also highlights that there are wide gaps of uncertainty, despite the growing awareness that individual differences shape the effects of evening/night light on sleep and circadian physiology. These include (1) why do certain individual traits differentially affect the influence of light on sleep and circadian rhythms; (2) what is the translational value of individual differences in light sensitivity in populations typically exposed to light at night, such as night shift workers; and (3) what is the magnitude of individual differences in light sensitivity in population-based studies? Collectively, the current findings provide strong support for considering individual differences when defining optimal lighting specifications, thus allowing for personalized lighting solutions that promote quality of life and health.

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Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Life between Clocks: Daily Temporal Patterns of Human Chronotypes
Roenneberg, T., Wirz-Justice, A., & Merrow, M. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730402239679 · Cited by 2,662
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
Brainard, G. C., Hanifin, J. P., Greeson, J. M., Byrne, B., Glickman, G., Gerner, E., & Rollag, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06405.2001 · Cited by 1,930
The new world atlas of artificial night sky brightness
Falchi, F., Cinzano, P., Duriscoe, D. M., Kyba, C. C. M., Elvidge, C. D., Baugh, K., Portnov, B. A., Rybnikova, N. A., & Furgoni, R. (2016) · Science Advances · doi:10.1126/sciadv.1600377 · Cited by 1,695
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460
Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness.
Chang, A.-M., Aeschbach, D., Duffy, J. F., & Czeisler, C. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418490112 · Cited by 1,430 · cited 1×
“longer sleep latency, altered slow-wave activity dynamics) [35, 43, 44].”
Background
An action spectrum for melatonin suppression: evidence for a novel non‐rod, non‐cone photoreceptor system in humans
Thapan, K., Arendt, J., & Skene, D. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00261.x · Cited by 1,320
Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression
Zeitzer, J. M., Dijk, D., Kronauer, R. E., Brown, E. N., & Czeisler, C. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00695.x · Cited by 1,175

Show all 130 references

Research works printed but not linked: 2

Boyce, 2003, The Benefits of Daylight Through Windows
Chellappa, 2019, Association, JAMA Ophthalmol., 137

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Authors: Chellappa, S. L.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Chellappa, Sarah L
ORCID: Chellappa, Sarah L
Venue: Sleep
Publisher: Oxford University Press (OUP)
Published: 2020-10-13
Volume: 44
Issue: 2
ISSN: 0161-8105 (ISSN-L)
1550-9109
DOI: 10.1093/sleep/zsaa214
PMC: PMC7879412
OpenAlex: W3091969560
Cited by: 163
References: 130
Citations by year: 2026: 27 · 2025: 43 · 2024: 30 · 2023: 28 · 2022: 19 · 2021: 16
FWCI: 2.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: SLEEP (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Funders: National Institutes of Health (STaR/0015/2013)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords: individual differences, photosensitivity, circadian rhythm, melatonin suppression, artificial light at night, evening light exposure, chronotype, haplotypes, age and sex differences, night shift workers, personalized lighting, retina
MeSH terms: Circadian Rhythm, Humans, Individuality, Melatonin, Quality of Life, Sleep, Photophobia

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Individual differences in light sensitivity affect sleep and circadian rhythms

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