The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease
Abstract
This study was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease (AD) by preventing β‐amyloid (Aβ) neuropathology pivotal to the initiation and progression of the disease. We report that a CR dietary regimen prevents Aβ peptides generation and neuritic plaque deposition in the brain of a mouse model of AD neuropathology through mechanisms associated with promotion of anti‐amyloidogenic α‐secretase activity. Study findings support existing epidemiological evidence indicating that caloric intake may influence risk for AD and raises the possibility that CR may be used in preventative measures aimed at delaying the onset of AD amyloid neuropathology.
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Cites
Pathways towards and Away from Alzheimer’s Disease
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“Moreover, because ADtype amyloid neuropathology is undetectable in the brain of 3-month-old Tg2576 mice ( 12 ), the age when our mice were initially exposed to the CR dietary regimen, our studies support the possibility that CR, by promoting α-secretase activity preventively, possibly through mechanisms involving ADAM…”
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Impact of intermittent fasting on health and disease processes
Mattson, M. P., Longo, V. D., & Harvie, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.005 · Cited by 1,187
Ageing and neuronal vulnerability
Mattson, M. P., & Magnus, T. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1886 · Cited by 957
Mattson, M. P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00275.x · Cited by 751
Histone acetylation: molecular mnemonics on the chromatin
Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680
Intermittent metabolic switching, neuroplasticity and brain health
Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.156 · Cited by 624
Metadata
- Authors
- Wang, J., Ho, L., Qin, W., Rocher, A. B., Seror, I., Humala, N., Maniar, K., Dolios, G., Wang, R., Hof, P. R., & Pasinetti, G. M.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2005-01-13
- Volume
- 19
- Issue
- 6
- Pages
- 1-18
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2095853881
- Cited by
- 316
- References
- 7
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- onlinelibrary.wiley.com/termsAndConditions#vor (vor)
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
- Funders
- National Institute on Aging (AG02219)
- Dana Foundation
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- Wang, J., Ho, L., Qin, W., Rocher, A. B., Seror, I., Humala, N., Maniar, K., Dolios, G., Wang, R., Hof, P. R., & Pasinetti, G. M. (2005). Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease. The FASEB Journal. https://doi.org/10.1096/fj.04-3182fje
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
