The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Increased migration and metastatic potential of tumor cells expressing aquaporin water channels
Abstract
Aquaporin (AQP) water channels are expressed in high‐grade tumor cells of different tissue origins. Based on the involvement of AQPs in angiogenesis and cell migration, we tested whether AQP expression in tumor cells might enhance their migration and metastatic potential. Transfection of B16F10 and 4T1 tumor cells with AQP1 did not affect their appearance, size, growth, or substrate adherence but increased their plasma membrane osmotic water permeability by 5‐ to 10‐fold. In vitro analysis of cell migration by transwell assay, wound healing and video microscopy showed a 2‐ to 3‐fold accelerated migration of the AQP1‐expressing tumor cells compared to control cells. In mice, AQP1 expression increased tumor cell extravasation by > 1.5‐fold as quantified by counting tumor cells in lung at 6 h after tail vein injection of a mixture of fluorescently tagged AQP1‐expressing and control tumor cells. AQP1 expression also increased by 3‐fold the number of lung metastases 14 days after tail vein injection of tumor cells, with alveolar wall infiltration seen with AQP1‐expressing tumor cells. Our results provide evidence for AQP‐facilitated tumor cell migration and spread, suggesting a novel function for AQP expression in high‐grade tumors. AQP inhibition may thus reduce the metastatic potential of some tumors.—Hu, J., Verkman, A. S. Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J . 20, 1228–1236 (2006)
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Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Tumour-cell invasion and migration: diversity and escape mechanisms
Friedl, P., & Wolf, K. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1075 · Cited by 3,222
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
Liotta, L. A., Steeg, P. S., & Stetler-Stevenson, W. G. (1991) · Cell · doi:10.1016/0092-8674(91)90642-c · Cited by 2,720
Aquaporin water channels – from atomic structure to clinical medicine
Agre, P., King, L. S., Yasui, M., Guggino, W. B., Ottersen, O. P., Fujiyoshi, Y., Engel, A., & Nielsen, S. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.020818 · Cited by 1,139
Biological Diversity in Metastatic Neoplasms: Origins and Implications
Fidler, I. J., & Hart, I. R. (1982) · Science · doi:10.1126/science.7112116 · Cited by 928
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
Saadoun, S., Papadopoulos, M. C., Hara-Chikuma, M., & Verkman, A. S. (2005) · Nature · doi:10.1038/nature03460 · Cited by 728
Self-citationMore than just water channels: unexpected cellular roles of aquaporins
Verkman, A. S. (2005) · Journal of Cell Science · doi:10.1242/jcs.02519 · Cited by 604
Self-citationInvolvement of aquaporin-4 in astroglial cell migration and glial scar formation
Saadoun, S., Papadopoulos, M. C., Watanabe, H., Yan, D., Manley, G. T., & Verkman, A. S. (2005) · Journal of Cell Science · doi:10.1242/jcs.02680 · Cited by 464
Self-citationAquaporin-4 expression is increased in oedematous human brain tumours
Saadoun, S. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.2.262 · Cited by 376
Solenov, E., Watanabe, H., Manley, G. T., & Verkman, A. S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00298.2003 · Cited by 329
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Cited by
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Aquaporins: important but elusive drug targets
Verkman, A. S., Anderson, M. O., & Papadopoulos, M. C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4226 · Cited by 586
Self-citationPapadopoulos, M. C., Saadoun, S., & Verkman, A. S. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0357-5 · Cited by 428
Self-citationRole of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Aquaporins in Clinical Medicine
Verkman, A. S. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-043010-193843 · Cited by 388
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Metadata
- Authors
- Hu, J., Verkman, A. S., Hu, J., & Verkman, A. S.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-07-03
- Volume
- 20
- Issue
- 11
- Pages
- 1892-1894
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2117506568
- Cited by
- 332
- References
- 27
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
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