The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Epidermal stem cells arise from the hair follicle after wounding
Abstract
During normal development, the epidermis and hair follicle are distinct lineage compartments maintained by independent stem cell populations. Both epidermal and follicular keratinocytes are recruited to participate in epidermal repair in response to injury. However, it is generally thought that follicular cells contribute to the wound epidermis only transiently and are ultimately replaced by the progeny of stem cells derived from the original epidermal compartment prior to wounding. Here we use inducible and constitutive cre recombinase expressed from the Sonic hedgehog locus (Shh) for in vivo lineage tracing. This analysis confirms that follicular cells participate in the initial resurfacing of the wound but also reveals that their progeny persist in wound epidermis for months after the wound is healed. It further demonstrates that Shh is not induced in keratinocytes during the wound healing process. We conclude that follicular cells can undergo reprogramming to become long‐term repopulating epidermal progenitors following wounding.—Levy, V., Lindon, C., Zheng, Y., Harfe, B. D., Morgan, B. A. Epidermal stem cells arise from the hair follicle after wounding. FASEB J. 21, 1358–1366 (2007)
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Cites
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Capturing and profiling adult hair follicle stem cells
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Self-citationTHE EPIDERMAL PROLIFERATIVE UNIT: THE POSSIBLE ROLE OF THE CENTRAL BASAL CELL
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Cited by
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270
The Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., et al. (2010) · Science · doi:10.1126/science.1184733 · Cited by 751
Inflammatory memory sensitizes skin epithelial stem cells to tissue damage
Naik, S., Larsen, S. B., Gomez, N. C., Alaverdyan, K., Sendoel, A., Yuan, S., Polak, L., Kulukian, A., Chai, S., & Fuchs, E. (2017) · Nature · doi:10.1038/nature24271 · Cited by 745
Metadata
- Authors
- Levy, V., Lindon, C., Zheng, Y., Harfe, B. D., & Morgan, B. A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2007-01-25
- Volume
- 21
- Issue
- 7
- Pages
- 1358-1366
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1974805319
- Cited by
- 386
- References
- 27
- FWCI
- 26.95
- Type
- journal article
- Language
- en
- Open access
- closed
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