Cited by 167Epigenetics and DNA MethylationFolate and B Vitamins ResearchNeurogenesis and neuroplasticity mechanisms

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Choline deficiency alters global histone methylation and epigenetic marking at the Rel site of the calbindin 1 gene

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Mehedint, Mihai G., Niculescu, Mihai D., Craciunescu, Corneliu N., Zeisel, Steven H.·2010·The FASEB Journal

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Abstract

Maternal choline availability is essential for fetal neurogenesis. Choline deprivation (CD) causes hypomethylation of specific CpG islands in genes controlling cell cycling in fetal hippocampus. We now report that, in C57BL/6 mice, CD during gestational days 12-17 also altered methylation of the histone H3 in E17 fetal hippocampi. In the ventricular and subventricular zones, monomethyl-lysine 9 of H3 (H3K9me1) was decreased by 25% (P<0.01), and in the pyramidal layer, dimethyl-lysine 9 of H3 (H3K9me2) was decreased by 37% (P<0.05). These changes were region specific and were not observed in whole-brain preparations. Also, the same effects of CD on H3 methylation were observed in E14 neural progenitor cells (NPCs) in culture. Changes in G9a histone methyltransferase might mediate altered H3K9me2,1. Gene expression of G9a was decreased by 80% in CD NPCs (P<0.001). In CD, H3 was hypomethylated upstream of the RE1 binding site in the calbindin 1 promoter, and 1 CpG site within the calbindin1 promoter was hypermethylated. REST binding to RE1 (recruits G9a) was decreased by 45% (P<0.01) in CD. These changes resulted in increased expression of calbindin 1 in CD (260%; P<0.05). Thus, CD modulates histone methylation in NPCs, and this could underlie the observed changes in neurogenesis.

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
EMBOSS: the European molecular biology open software suite.
Rice, P., Longden, I., & Bleasby, A. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02024-2 · Cited by 9,466
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
Histone demethylation by a family of JmjC domain-containing proteins
Tsukada, Y.-I., Fang, J., Erdjument‐Bromage, H., Warren, M., Borchers, C. H., Tempst, P., & Zhang, Y. (2005) · Nature · doi:10.1038/nature04433 · Cited by 2,244
The diverse functions of histone lysine methylation
Martin, C., & Zhang, Y. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1761 · Cited by 2,157
Active Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tailsPreprint
Zhang, Y., & Reinberg, D. (2001) · Genes & Development · doi:10.1101/gad.927301 · Cited by 1,639
Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse
Bernstein, B., Kamal, M., Lindblad‐Toh, K., Bekiranov, S., Bailey, D. K., Huebert, D. J., McMahon, S., Karlsson, E. K., Kulbokas, E. J., Gingeras, T., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.001 · Cited by 1,567
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesisPreprint
Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., et al. (2002) · Genes & Development · doi:10.1101/gad.989402 · Cited by 1,294
Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin
Lehnertz, B., Ueda, Y., Derijck, A. A. H. A., Braunschweig, U., Perez-Burgos, L., Kubicek, S., Chen, T., Li, E., Jenuwein, T., & Peters, A. H. F. M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00432-9 · Cited by 1,289
Controlling the double helix
Felsenfeld, G., & Groudine, M. T. (2003) · Nature · doi:10.1038/nature01411 · Cited by 1,252
Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin
Peters, A. H. F. M., Kubicek, S., Mechtler, K., O’Sullivan, R. J., Derijck, A. A. H. A., Perez-Burgos, L., Kohlmaier, A., Opravil, S., Tachibana, M., Shinkai, Y., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00477-5 · Cited by 1,208
Targeted Recruitment of Set1 Histone Methylase by Elongating Pol II Provides a Localized Mark and Memory of Recent Transcriptional Activity
Ng, H., Robert, F., Young, R. A., & Struhl, K. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00092-3 · Cited by 1,131
Regulation of histone acetylation during memory formation in the hippocampus
Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
Fuks, F., Burgers, W. A., Brehm, A., Hughes‐Davies, L., & Kouzarides, T. (2000) · Nature Genetics · doi:10.1038/71750 · Cited by 988
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
Chong, J. A., Tapia-Ramirez, J., Kim, S., Toledo-Aral, J. J., Zheng, Y., Boutros, M. C., Altshuller, Y. M., Frohman, M. A., Kraner, S. D., & Mandel, G. (1995) · Cell · doi:10.1016/0092-8674(95)90298-8 · Cited by 967
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
Pasini, D., Bracken, A. P., Jensen, M. R., Denchi, E. L., & Helin, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600402 · Cited by 963
REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis
Ballas, N., Grunseich, C., Lu, D. D., Speh, J. C., & Mandel, G. (2005) · Cell · doi:10.1016/j.cell.2005.03.013 · Cited by 950
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9Preprint
Tachibana, M., Ueda, J., Fukuda, M., Takeda, N., Ohta, T., Iwanari, H., Sakihama, T., Kodama, T., Hamakubo, T., & Shinkai, Y. (2005) · Genes & Development · doi:10.1101/gad.1284005 · Cited by 868
Histone Methyltransferases Direct Different Degrees of Methylation to Define Distinct Chromatin Domains
Rice, J. C., Briggs, S. D., Ueberheide, B. M., Barber, C. M., Shabanowitz, J., Hunt, D. F., Shinkai, Y., & Allis, C. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00479-9 · Cited by 849
SET Domain-containing Protein, G9a, Is a Novel Lysine-preferring Mammalian Histone Methyltransferase with Hyperactivity and Specific Selectivity to Lysines 9 and 27 of Histone H3
Tachibana, M., Sugimoto, K., Fukushima, T., & Shinkai, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101914200 · Cited by 784
Methylation of histone H3 Lys 4 in coding regions of active genes
Bernstein, B., Humphrey, E. L., Erlich, R., Schneider, R., Bouman, P., Liu, J. S., Kouzarides, T., & Schreiber, S. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082249499 · Cited by 778
Epigenetic mechanisms in memory formation
Levenson, J. M., & Sweatt, J. D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1604 · Cited by 767
Choline: Critical Role During Fetal Development and Dietary Requirements in Adults
Zeisel, S. H. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111156 · Cited by 741
Self-citation
Histone methylation versus histone acetylation: new insights into epigenetic regulation
Rice, J. C., & Allis, C. D. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00208-8 · Cited by 701
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
Klose, R. J., Yamane, K., Bae, Y., Zhang, D., Erdjument‐Bromage, H., Tempst, P., Wong, J., & Zhang, Y. (2006) · Nature · doi:10.1038/nature04853 · Cited by 648
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replicationPreprint
Estève, P., Chin, H. G., Smallwood, A., Feehery, G. R., Gangisetty, O., Karpf, A. R., Carey, M., & Pradhan, S. (2006) · Genes & Development · doi:10.1101/gad.1463706 · Cited by 565
Neural tube defects and folate: case far from closed
Blom, H. J., Shaw, G. M., den Heijer, M., & Finnell, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1986 · Cited by 562
Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4.
Sobel, R. E., Cook, R. G., Perry, C. A., Annunziato, A. T., & Allis, C. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.4.1237 · Cited by 513
Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure
Guan, Z., Giustetto, M., Lomvardas, S., Kim, J.-H., Miniaci, M. C., Schwartz, J. H., Thanos, D., & Kandel, E. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01074-7 · Cited by 497
Integrating the MAP kinase signal into the G1 phase cell cycle machinery
Roovers, K., & Assoian, R. K. (2000) · BioEssays · doi:10.1002/1521-1878(200009)22:9 · Cited by 475
The many faces of REST oversee epigenetic programming of neuronal genes
Ballas, N., & Mandel, G. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.015 · Cited by 451
A small modulatory dsRNA specifies the fate of adult neural stem cells
Kuwabara, T., Hsieh, J., Nakashima, K., Taira, K., & Gage, F. H. (2004) · Cell · doi:10.1016/s0092-8674(04)00248-x · Cited by 447
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
Loh, Y.-H., Zhang, W., Chen, X., George, J., & Ng, H.-H. (2007) · Genes & Development · doi:10.1101/gad.1588207 · Cited by 443
Chromatin crosstalk in development and disease: lessons from REST
Ooi, L., & Wood, I. C. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2100 · Cited by 405
Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells
Altman, J., & Bayer, S. A. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903010302 · Cited by 401
Structure and catalytic mechanism of the human histone methyltransferase SET7/9
Xiao, B., Jing, C., Wilson, J. R., Walker, P. A., Vasisht, N., Kelly, G. P., Howell, S. A., Taylor, I. A., Blackburn, G. M., & Gamblin, S. J. (2003) · Nature · doi:10.1038/nature01378 · Cited by 395
Periconceptional Dietary Intake of Choline and Betaine and Neural Tube Defects in Offspring
Shaw, G. M., Carmichael, S. L., Yang, W., Selvin, S., & Schaffer, D. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh187 · Cited by 362
Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains
Niculescu, M. D., Craciunescu, C. N., & Zeisel, S. H. (2006) · The FASEB Journal · doi:10.1096/fj.05-4707com · Cited by 330
Self-citation
Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan
Meck, W. H., & Williams, C. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00069-1 · Cited by 324
Localized Domains of G9a-Mediated Histone Methylation Are Required for Silencing of Neuronal Genes
Roopra, A., Qazi, R., Schoenike, B. A., Daley, T. J., & Morrison, J. F. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.026 · Cited by 286
Pre‐ and postnatal choline supplementation produces long‐term facilitation of spatial memory
Meck, W. H., Smith, R. A., & Williams, C. L. (1988) · Developmental Psychobiology · doi:10.1002/dev.420210405 · Cited by 269
Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression
Kovacheva, V., Mellott, T. J., Davison, J. M., Wagner, N., G.‐Coviella, I. L., Schnitzler, A. C., & Blusztajn, J. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705539200 · Cited by 225
Epigenetic control of neural stem cell fate
Hsieh, J., & Gage, F. H. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.07.006 · Cited by 212
Choline supplementation during prenatal development reduces proactive interference in spatial memory
Meck, W. H., & Williams, C. L. (1999) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00105-4 · Cited by 193
Choline availability alters embryonic development of the hippocampus and septum in the rat
Albright, C. D., Tsai, A. Y., Friedrich, C. B., Mar, M.-H. H., & Zeisel, S. H. (1999) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00183-7 · Cited by 189
Self-citation
High Efficacy of Clonal Growth and Expansion of Adult Neural Stem Cells
Wachs, F., Couillard‐Després, S., Engelhardt, M., Wilhelm, D., Ploetz, S., Vroemen, M., Kaesbauer, J., Uyanik, G., Klucken, J., Karl, C., et al. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000075556.74231.a5 · Cited by 188
Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory
Meck, W. H., & Williams, C. L. (1997) · Neuroreport · doi:10.1097/00001756-199709080-00005 · Cited by 187
Chemoarchitectonic Atlas of the Developing Mouse Brain
Jacobowitz, D. M., & Abbott, L. C. (1997) · CRC Press eBooks · doi:10.1201/9781466593411 · Cited by 180
GeneFisher--software support for the detection of postulated genes.
Giegerich, R., Meyer, F., & Schleiermacher, C. (1996) · PubMed · Cited by 180
The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylationPreprint
Mutskov, V. J., Farrell, C. M., Wade, P. A., Wolffe, A. P., & Felsenfeld, G. (2002) · Genes & Development · doi:10.1101/gad.988502 · Cited by 180
Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks
Shivapurkar, N., & Poirier, L. A. (1983) · Carcinogenesis · doi:10.1093/carcin/4.8.1051 · Cited by 173
Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats
Meck, W. H., & Williams, C. L. (1997) · Neuroreport · doi:10.1097/00001756-199709290-00009 · Cited by 171
Choline Availability During Embryonic Development Alters Progenitor Cell Mitosis in Developing Mouse Hippocampus
Craciunescu, C. N., Albright, C. D., Mar, M.-H. H., Song, J., & Zeisel, S. H. (2003) · Journal of Nutrition · doi:10.1093/jn/133.11.3614 · Cited by 171
Self-citation
Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum
Albright, C. D., Friedrich, C. B., Brown, E. C., Mar, M.-H. H., & Zeisel, S. H. (1999) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00057-7 · Cited by 149
Self-citation
Hypertrophy of basal forebrain neurons and enhanced visuospatial memory in perinatally choline-supplemented rats
Williams, C. L., Meck, W. H., Heyer, D., & Loy, R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00229-7 · Cited by 146
Perinatal choline supplementation increases the threshold for chunking in spatial memory
Meck, W. H., & Williams, C. L. (1997) · Neuroreport · doi:10.1097/00001756-199709290-00010 · Cited by 144
Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro
Fisher, M. C., Zeisel, S. H., Mar, M.-H. H., & Sadler, T. W. (2002) · The FASEB Journal · doi:10.1096/fj.01-0564fje · Cited by 130
Self-citation
Automethylation of G9a and its implication in wider substrate specificity and HP1 binding
Chin, H. G., Estève, P., Pradhan, M., Benner, J. S., Patnaik, D., Carey, M., & Pradhan, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm726 · Cited by 127
G9a and Jhdm2a Regulate Embryonic Stem Cell Fusion-Induced Reprogramming of Adult Neural Stem Cells
Ma, D. K., Chiang, C.-H. J., Ponnusamy, K. E., Ming, G., & Song, H. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0388 · Cited by 120
Cell cycle and cell fate interactions in neural development
Cremisi, F., Philpott, A., & Ohnuma, S. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00005-9 · Cited by 118
Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver
Zeisel, S. H., Zola, T. H., daCosta, K.-A., & Pomfret, E. A. (1989) · Biochemical Journal · doi:10.1042/bj2590725 · Cited by 107
Self-citation
Choline deficiency induces apoptosis in SV40‐immortalized CWSV‐1 rat hepatocytes in culture 1
Albright, C. D., Liu, R., Bethea, T. C., da Costa, K.-A., Salganik, R. I., & Zeisel, S. H. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.4.8647350 · Cited by 100
Self-citation
Free and Phospholipid-Bound Choline Concentrations in Serum during Pregnancy, after Delivery and in Newborns
İlçöl, Y. Ö., Uncu, G., & Ulus, İ. H. (2002) · Archives of Physiology and Biochemistry · doi:10.1076/apab.110.5.393.11832 · Cited by 98
Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos
Fisher, M. C., Zeisel, S. H., Mar, M.-H. H., & Sadler, T. W. (2001) · Teratology · doi:10.1002/tera.1053 · Cited by 87
Self-citation
Age- and behavior-related variation in volumes of song control nuclei in male European starlings
Bernard, D. J., Eens, M., & Ball, G. F. (1996) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199607)30:3 · Cited by 85
Choline in the diets of the US population: NHANES, 2003–2004
Jensen, H. H., Batres-Marquez, S. P., Carriquiry, A., & Schalinske, K. L. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.6.lb46-c · Cited by 78
RE1 Silencing Transcription Factor Maintains a Repressive Chromatin Environment in Embryonic Hippocampal Neural Stem Cells
Guest, D. J., Street, M., Jeffries, A. R., & Buckley, N. J. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0207 · Cited by 72
Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brain.
Niculescu, M., Craciunescu, C., & Zeisel, S. (2005) · Brain Research. Molecular Brain Research · doi:10.1016/j.molbrainres.2004.11.001 · Cited by 56
Self-citation
Choline Availability During Embryonic Development Alters the Localization of Calretinin in Developing and Aging Mouse Hippocampus
Albright, C. D., Siwek, D. F., Craciunescu, C. N., Mar, M.-H. H., Kowall, N. W., Williams, C. L., & Zeisel, S. H. (2003) · Nutritional Neuroscience · doi:10.1080/1028415031000084418 · Cited by 45
Self-citation
Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus
Zhu, X., Mar, M.-H. H., Song, J., & Zeisel, S. H. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.01.004 · Cited by 38
Self-citation
Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus
Albright, C. D., Mar, M.-H. H., Craciunescu, C. N., Song, J., & Zeisel, S. H. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.07.002 · Cited by 33
Self-citation
Isolation of neural stem and precursor cells from rodent tissue.
Wu, Y.-Y., Liu, Y., Chesnut, J., & Rao, M. S. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-133-8_5 · Cited by 17

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Authors: Mehedint, M. G., Niculescu, M. D., Craciunescu, C. N., & Zeisel, S. H.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Zeisel, Steven H.
ORCID: Niculescu, Mihai D.
Zeisel, Steven H.
Venue: The FASEB Journal
Publisher: Wiley
Published: 2009-09-14
Volume: 24
Issue: 1
Pages: 184-195
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.09-140145
PMC: PMC2797040
OpenAlex: W2070463636
Cited by: 167
References: 77
Citations by year: 2026: 3 · 2025: 1 · 2024: 9 · 2023: 2 · 2022: 13 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 4 · 2017: 15 · 2016: 11 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 27
FWCI: 6.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AG-09525, DK-55865)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: choline deficiency, histone H3 methylation, H3K9me1, H3K9me2, G9a, rest, neural progenitor cells, fetal hippocampus, neurogenesis, epigenetic regulation, CpG methylation, fetal development
MeSH terms: RE1-Silencing Transcription Factor, Animals, Base Sequence, Binding Sites, Cells, Cultured, Choline Deficiency, DNA, Female, Hippocampus, Histones, Methylation, Mice, Inbred C57BL, Mitosis, Models, Biological, Pregnancy, Promoter Regions, Genetic, Histone-Lysine N-Methyltransferase, Repressor Proteins, Apoptosis, CpG Islands, Epigenesis, Genetic, Mice, Embryonic Stem Cells, Calbindins, S100 Calcium Binding Protein G, Calbindin 1

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Choline deficiency alters global histone methylation and epigenetic marking at the Rel site of the calbindin 1 gene

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