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In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial
Abstract
The aim of the study was to assess whether benefits associated with the traditional Mediterranean diet (TMD) and virgin olive oil (VOO) consumption could be mediated through changes in the expression of atherosclerosis‐related genes. A randomized, parallel, controlled clinical trial in healthy volunteers ( n =90) aged 20 to 50 yr was performed. Threemonth intervention groups were as follows: 1 ) TMD with VOO (TMD+VOO), 2 ) TMD with washed virgin olive oil (TMD+WOO), and 3 ) control with participants’ habitual diet. WOO was similar to VOO, but with a lower polyphenol content (55 vs. 328 mg/kg, respectively). TMD consumption decreased plasma oxidative and inflammatory status and the gene expression related with both inflammation [INF‐γ ( INFy ), Rho GTPase‐activating protein15 ( ARHGAP15 ), and interleukin‐7 receptor ( IL7R)] and oxidative stress [adrenergic ß 2 ‐receptor ( ADRB2 ) and polymerase (DNA‐directed) κ ( POLK)] in peripheral blood mononuclear cells. All effects, with the exception of the decrease in POLK expression, were particularly observed when VOO, rich in polyphenols, was present in the TMD dietary pattern. Our results indicate a significant role of olive oil polyphenols in the down‐regulation of proatherogenic genes in the context of a TMD. In addition, the benefits associated with a TMD and olive oil polyphenol consumption on cardiovascular risk can be mediated through nutrigenomic effects.—Konstantinidou, V., Covas, M.‐I., Mun˜oz‐Aguayo, D., Khymenets, O., de la Torre, R., Saez, G., del Carmen Tormos, M., Toledo, E., Marti, A., Ruiz‐Gutiérrez, V., Ruiz Mendez, M. V., Fito, M. In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial. FASEBJ. 24, 2546–2557 (2010). www.fasebj.org
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Metadata
- Authors
- Konstantinidou, V., Covas, M., Muñoz‐Aguayo, D., Khymenets, O., de la Torre, R., Saez, G., del Carmen Tormos, M., Toledo, E., Marti, A., Ruiz‐Gutiérrez, V., Mendez, M. V. R., & Fito, M.
- Affiliations
- Centro de Investigación Biomédica en Red (ES)
- Cardiovascular Risk and Nutrition Research Group Institut Municipal d’Investigació Medica (IMIM‐Hospital del Mar) Centro de Investigación Biomédica Eu Red (CIBER) de Fisiopatología de la Obesidad y Nutrición Barcelona Spain
- Human Pharmacology and Clinical Neurosciences Research Group Institut Municipal d’Investigació Mèdica (IMIM‐Hospital del Mar) Centro de Investigación Biomédica Eu Red (CIBER) de Fisiopatología de la Obesidad y Nutrición Barcelona Spain
- Department of Biochemistry and Molecular Biology University of Valencia Valencia Spain
- Department of Preventive Medicine and Public Health University of Navarra Navarra Spain
- Department of Nutrition Food Science Physiology and Toxicology University of Navarra Navarra Spain
- Instituto de Nutrition and Lipid Metabolism Instituto de la Grasa Seville Spain
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2010-02-23
- Volume
- 24
- Issue
- 7
- Pages
- 2546-2557
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2164353743
- Semantic Scholar
- 08a7f0f7373ac654a192b9c0551445eb9391856c
- Cited by
- 274
- References
- 62
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 13 · 2022: 12 · 2021: 13 · 2020: 17 · 2019: 28 · 2018: 14 · 2017: 17 · 2016: 21 · 2015: 30 · 2014: 22 · 2013: 19 · 2012: 26
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- virgin olive oil, olive oil polyphenols, Mediterranean diet, nutrigenomics, atherosclerosis, gene expression, inflammation, oxidative stress, peripheral blood mononuclear cells, interferon-gamma, CD127, ADRB2, DNA polymerase kappa, cardiovascular risk
- MeSH terms
- Olive Oil, Adult, Cardiovascular Diseases, Flavonoids, Gene Expression Regulation, Humans, Inflammation, Middle Aged, Oxidation-Reduction, Phenols, Plant Oils, Down-Regulation, Diet, Mediterranean, Atherosclerosis, Nutrigenomics, Young Adult, Polyphenols
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