The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Neurocircuitry Targets in Ethanol Reward and Dependence
Abstract
Alcoholism is a complex behavioral disorder characterized by excessive consumption of ethanol, a narrowing of the behavioral repertoire toward excessive consumption, the development of tolerance and dependence, and impairment in social and occupational functioning. Animal models of the complete syndrome of alcoholism are difficult if not impossible to achieve, but validated animal models exist for many of the different components of the syndrome. Recent work has begun to define the neurocircuits responsible for the two major sources of reinforcement key to animal models of excessive ethanol intake: positive and negative reinforcement. Ethanol appears to interact with ethanol-sensitive elements within neuronal membranes that convey the specificity of neurochemical action. Ethanol reinforcement appears to be mediated by an activation of GABA-A receptors, release of opioid peptides, release of dopamine, inhibition of glutamate receptors, and interaction with serotonin systems. These neurocircuits may be altered by chronic ethanol administration as reflected by opposite effects during acute ethanol withdrawal and by the recruitment of other neurotransmitter systems such as the stress neuropeptide corticotropin-releasing factor. Future challenges will include a focus on understanding how these neuroadaptive changes convey vulnerability to relapse in animals with a history of ethanol dependence.
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2022) · doi:10.1176/appi.books.9780890425787 · Cited by 23,476
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Cited by
Anton, R. F., O’Malley, S. S., Ciraulo, D. A., Cisler, R. A., Couper, D., Donovan, D. M., Gastfriend, D. R., Hosking, J. D., Johnson, B. A., LoCastro, J. S., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2003 · Cited by 1,930
Jackson, J. S., Knight, K. M., & Rafferty, J. A. (2010) · American Journal of Public Health · doi:10.2105/ajph.2008.143446 · Cited by 840
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Jayne, M., Ma, Y., Pradhan, K., & Wong, C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3371-07.2007 · Cited by 494
Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.78 · Cited by 466
Can food be addictive? Public health and policy implications
Gearhardt, A. N., Grilo, C. M., DiLeone, R. J., Brownell, K. D., & Potenza, M. N. (2011) · Addiction · doi:10.1111/j.1360-0443.2010.03301.x · Cited by 396
Metadata
- Authors
- Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyyti??, P., Merlo-Pich, E., & Weiss, F.
- Venue
- Alcoholism: Clinical & Experimental Research
- Publisher
- Wiley
- Published
- 1998-02
- Volume
- 22
- Issue
- 1
- Pages
- 3
- ISSN
- 0145-6008 (ISSN-L)
- OpenAlex
- W1990621985
- Cited by
- 560
- References
- 38
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyyti??, P., Merlo-Pich, E., & Weiss, F. (1998). Neurocircuitry Targets in Ethanol Reward and Dependence. Alcoholism: Clinical & Experimental Research. https://doi.org/10.1097/00000374-199802000-00001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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