Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals
Open accessAbstract
Chronic alcohol abuse is associated with changes in stress and reward pathways that could alter vulnerability to emotional stress and alcohol craving. This study examines whether chronic alcohol abuse is associated with altered stress and alcohol craving responses. Treatment-engaged, 28-day abstinent alcohol-dependent individuals (ADs; 6F/22M), and social drinkers (SDs; 10F/18M) were exposed to a brief guided imagery of a personalized stressful, alcohol-related and neutral-relaxing situation, one imagery condition per session, presented in random order across 3 days. Alcohol craving, anxiety and emotion ratings, behavioral distress responses, heart rate, blood pressure, and salivary cortisol measures were assessed. Alcohol patients showed significantly elevated basal heart rate and salivary cortisol levels. Stress and alcohol cue exposure each produced a significantly enhanced and persistent craving state in alcohol patients that was marked by increased anxiety, negative emotion, systolic blood pressure responses, and, in the case of alcohol cue, behavioral distress responses, as compared to SDs. Blunted stress-induced cortisol responses were observed in the AD compared to the SD group. These data are the first to document that stress and cue exposure induce a persistent negative emotion-related alcohol craving state in abstinent alcoholics accompanied by dysregulated HPA and physiological arousal responses. As laboratory models of stress and negative mood-induced alcohol craving are predictive of relapse outcomes, one implication of the current data is that treatments targeting decreases in stress and alcohol cue-induced craving and regulation of stress responses could be of benefit in improving alcohol relapse outcomes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Responses to stress cues were on the whole comparable to those induced by alcohol-associated cues.
“These responses to stress cues were on the whole comparable to those induced by alcohol-associated cues (Fox et al., 2007; Sinha et al., 2009; Sinha & Li, 2007)”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Sinha et al., 2009
Cites
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923 · see citing works
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340 · see citing works
SULLIVAN, J. T., SYKORA, K., SCHNEIDERMAN, J., NARANJO, C. A., & SELLERS, E. M. (1989) · British Journal of Addiction · doi:10.1111/j.1360-0443.1989.tb00737.x · Cited by 1,988 · see citing works
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638 · cited 1× · see citing works
“Furthermore, unlike in the SD group, where higher HRs were associated with cue-induced alcohol craving as previously reported in the literature (Carter and Tiffany, 1999), the AD group showed increased HR in the cue condition but no association between increased HR and craving levels.”
ResultThe reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works
Self-citationThe genetics of addictions: uncovering the genes
Goldman, D., Oroszi, G., & Ducci, F. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1635 · Cited by 1,099 · see citing works
Stress dysregulation of drug reward pathways, and the transition to drug dependence
Koob, & Kreek, M. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.05030503 · Cited by 868 · see citing works
Alcoholism: Allostasis and Beyond
Koob, G. F. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000057122.36127.c2 · Cited by 737 · see citing works
American drinking practices : a national study of drinking behavior and attitudes
Cahalan, D., Cisin, I. H., & Crossley, H. M. (1969) · Medical Entomology and Zoology · Cited by 628 · see citing works
Neurobiological mechanisms in the transition from drug use to drug dependence
Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., O’Dell, L. E., Parsons, L. H., & Sanna, P. P. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.007 · Cited by 576 · see citing works
Neurocircuitry Targets in Ethanol Reward and Dependence
Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytiä, P., Merlo‐Pich, E., & Weiss, F. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03611.x · Cited by 560 · see citing works
Patterns of emotions a new analysis of anxiety and depression
Izard, C. E., Bartlett, E. S., & Marshall, A. G. (1972) · Cited by 530 · see citing works
Sinha, R., Garcia, M., Paliwal, P., Kreek, M. J., & Rounsaville, B. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.324 · Cited by 528 · see citing works
Self-citationAlcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & al, E. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.2.243 · Cited by 479 · see citing works
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & Gaupp, L. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.2.243 · Cited by 479 · see citing works
Psychological stress, drug-related cues and cocaine craving
Sinha, R., Fuse, T., Aubin, L.-R., & O'Malley, S. S. (2000) · Psychopharmacology · doi:10.1007/s002130000499 · Cited by 463 · see citing works
Self-citationAlcohol dependence is associated with blunted dopamine transmission in the ventral striatum
Martinez, D., Gil, R., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Kegeles, L., Talbot, P., Evans, S., Krystal, J., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.044 · Cited by 445 · see citing works
Lang, P. J., Levin, D. N., Miller, G. A., & Kozak, M. J. (1983) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.92.3.276 · Cited by 424 · see citing works
The role of stress in addiction relapse
Sinha, R. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0050-6 · Cited by 423 · see citing works
Self-citationNeurobiology of craving, conditioned reward and relapse
Weiss, F. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.11.001 · Cited by 411 · see citing works
Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Klein, S., Grüsser-Sinopoli, S. M., Flor, H., Braus, D. F., Buchholz, H. G., Gründer, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1783 · Cited by 408 · see citing works
Emotional Imagery: Conceptual Structure and Pattern of Somato‐Visceral Response
Lang, P. J., Kozak, M. J., Miller, G. A., Levin, D. N., & McLean, A. (1980) · Psychophysiology · doi:10.1111/j.1469-8986.1980.tb00133.x · Cited by 403 · see citing works
Stress-induced craving and stress response in cocaine dependent individuals
Sinha, R., Catapano, D., & O’Malley, S. S. (1999) · Psychopharmacology · doi:10.1007/s002130050898 · Cited by 403 · see citing works
Self-citationFunk, C. K., O'Dell, L. E., Crawford, E. F., & Koob, G. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3096-06.2006 · Cited by 381 · see citing works
Sinha, R., Talih, M., Malison, R. T., Cooney, N. L., Anderson, G. M., & Kreek, M. J. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1525-8 · Cited by 366 · see citing works
Self-citationLiu, X., & Weiss, F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07856.2002 · Cited by 359 · see citing works
Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats
Lê, A. D., Quan, B. H., Juzytsch, W., Fletcher, P. J., Joharchi, N., & Shaham, Y. (1998) · Psychopharmacology · doi:10.1007/s002130050498 · Cited by 319 · see citing works
Stress‐Induced and Alcohol Cue‐Induced Craving in Recently Abstinent Alcohol‐Dependent Individuals
Fox, H. C., Bergquist, K. L., Hong, K., & Sinha, R. (2007) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00320.x · Cited by 315 · see citing works
Self-citationOswald, L. M., Wong, D. F., McCaul, M., Zhou, Y., Kuwabara, H., Choi, L., Brasic, J., & Wand, G. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300667 · Cited by 314 · see citing works
Lê, A. D., Harding, S. E., Juzytsch, W., Watchus, J., Shalev, U., & Shaham, Y. (2000) · Psychopharmacology · doi:10.1007/s002130000411 · Cited by 310 · see citing works
Heinz, A., Siessmeier, T., Wrase, J., Buchholz, H. G., Gründer, G., Kumakura, Y., Cumming, P., Schreckenberger, M., Smolka, M. N., Rösch, F., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1515 · Cited by 285 · see citing works
Ingjaldsson, J. T., Laberg, J. C., & Thayer, J. F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01926-1 · Cited by 275 · see citing works
Krystal, J. H., Webb, E., Cooney, N. L., Kranzler, H. R., Southwick, S. W., Heninger, G. R., & Charney, D. S. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.1.83 · Cited by 269 · see citing works
Reactivity of alcoholics and nonalcoholics to drinking cues.
Monti, P. M., Binkoff, J. A., Abrams, D. B., Zwick, W. R., Nirenberg, T. D., & Liepman, M. R. (1987) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.96.2.122 · Cited by 268 · see citing works
Blunted Stress Cortisol Response in Abstinent Alcoholic and Polysubstance-Abusing Men
Lovallo, W. R., Dickensheets, S. L., Myers, D. A., Thomas, T. L., & Nixon, S. J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02036.x · Cited by 266 · see citing works
Stress Enhancement of Craving During Sobriety: A Risk for Relapse
Breese, G. R., Chu, K., Dayas, C. V., Funk, D. R., Knapp, D. J., Koob, G. F., Lê, A. D., Dell, L. E. O., Overstreet, D. H., Roberts, A. J., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000153544.83656.3c · Cited by 247 · see citing works
Self-citationAlterations in the Hypothalamic-Pituitary-Adrenal Axis in Actively Drinking Alcoholics*
Wand, G. S., & Dobs, A. S. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-6-1290 · Cited by 242 · see citing works
SHAW, J. M., Kolesar, G., Sellers, E. M., Kaplan, H. L., & Sandor, P. (1981) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198111000-00006 · Cited by 230 · see citing works
Lê, A. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00024-x · Cited by 228 · see citing works
Smoking, cortisol and nicotine
Steptoe, A., & USSHER, M. H. (2005) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.10.011 · Cited by 225 · see citing works
Chronic Daily Ethanol and Withdrawal: 1. Long-Term Changes in the Hypothalamo-Pituitary-Adrenal Axis
Rasmussen, D. D., Boldt, B. M., Bryant, C. A., Mitton, D. R., Larsen, S. A., & Wilkinson, C. W. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01988.x · Cited by 216 · see citing works
Suppression of the HPA Axis Stress‐Response: Implications for Relapse
Adinoff, B. H., Junghanns, K., Kiefer, F., & Krishnan‐Sarin, S. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000176356.97620.84 · Cited by 198 · see citing works
Thayer, J. F., Hall, M. H., Sollers, J. J., & Fischer, J. E. (2005) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.10.013 · Cited by 196 · see citing works
Fox, H. C., Hong, K., Siedlarz, K. M., & Sinha, R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301470 · Cited by 182 · see citing works
Self-citationWand, G. S., Oswald, L. M., McCaul, M. E., Wong, D. F., Johnson, E., Zhou, Y., Kuwabara, H., & Kumar, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301373 · Cited by 178 · see citing works
PATTERNS OF ACTH AND CORTISOL PULSATILITY OVER TWENTY‐FOUR HOURS IN NORMAL MALES AND FEMALES
Horrocks, P. M., Jones, A. F., RATCLIFFE, W. A., Holder, G., White, A. E., Holder, R. L., Ratcliffe, J. G., & LONDON, D. R. (1990) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1990.tb03758.x · Cited by 175 · see citing works
Pomerleau, O. F., Fertig, J. B., Baker, L. H., & Cooney, N. L. (1983) · Addictive Behaviors · doi:10.1016/0306-4603(83)90048-5 · Cited by 169 · see citing works
Impaired serum cortisol stress response is a predictor of early relapse
Junghanns, K. (2003) · Alcohol and Alcoholism · doi:10.1093/alcalc/agg052 · Cited by 166 · see citing works
Fox, H. C., Talih, M., Malison, R. T., Anderson, G. M., Kreek, M. J., & Sinha, R. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.05.002 · Cited by 164 · see citing works
Self-citationIncrease in Concentration of Waking Salivary Cortisol in Recovered Patients With Depression
Bhagwagar, Z., Hafizi, S., & Cowen, P. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.10.1890 · Cited by 161 · see citing works
Self-citationDisturbances of hypothalamic-pituitary-adrenal axis functioning during ethanol withdrawal in six men
Adinoff, B. H., Risher‐Flowers, D., de Jong, J., Ravitz, B., Bone, G. H. A., Nutt, D., Roehrich, L., Martin, P. R., & Linnoila, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.8.1023 · Cited by 154 · see citing works
The use of psychological and neuroendocrinological measurements in the study of stress.
Baum, A. E., Grunberg, N. E., & Singer, J. E. (1982) · Health Psychology · doi:10.1037/0278-6133.1.3.217 · Cited by 153 · see citing works
Severity of psychosocial stress and outcome of alcoholism treatment.
Brown, S. A., Vik, P. W., McQuaid, J. R., Patterson, T. L., Irwin, M. R., & Grant, I. (1990) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.99.4.344 · Cited by 135 · see citing works
Cognitive changes after alcohol cue exposure.
Cooney, N. L., Gillespie, R. A., Baker, L. H., & Kaplan, R. F. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.55.2.150 · Cited by 134 · see citing works
Adinoff, B. H., Ruether, K., Krebaum, S. R., Iranmanesh, A., & Williams, M. J. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000087581.13912.64 · Cited by 133 · see citing works
Gender differences in stress reactivity among cocaine-dependent individuals
Back, S. E., Brady, K. T., Jackson, J. L., Salstrom, S. A., & Zinzow, H. M. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2129-7 · Cited by 132 · see citing works
Craving for alcohol: findings from the clinic and the laboratory.
Sinha, R., & O’Malley, S. S. (1999) · Alcohol and Alcoholism · doi:10.1093/alcalc/34.2.223 · Cited by 119 · see citing works
Self-citationCosta, A. C., Bono, G., Martignoni, E., Merlo, P., Sances, G., & Nappi, G. (1996) · Psychoneuroendocrinology · doi:10.1016/0306-4530(96)00001-7 · Cited by 114 · see citing works
Attenuated cortisol response to alcohol in heavy social drinkers
King, A., Munisamy, G., de Wit, H., & Lin, S. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.10.008 · Cited by 114 · see citing works
The Role of Corticotropin‐Releasing Factor in the Anxiogenic Effects of Ethanol Withdrawal
Menzaghi, F., Rassnick, S., Heinrichs, S. C., Baldwin, H. A., Pich, E. M., Weiss, F., & Koob, G. F. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb19819.x · Cited by 109 · see citing works
Life-time socio-economic position and cortisol patterns in mid-life
Li, L., Power, C., Kelly, S., Kirschbaum, C., & Hertzman, C. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.014 · Cited by 109 · see citing works
Attenuated cortisol response to biobehavioral stressors in sober alcoholics.
Errico, A. L., Parsons, O. A., King, A. C., & Lovallo, W. R. (1993) · Journal of Studies on Alcohol · doi:10.15288/jsa.1993.54.393 · Cited by 107 · see citing works
Holsboer, F., von Bardeleben, U., Buller, R., Heuser, I., & Steiger, A. (1987) · PubMed · Cited by 106 · see citing works
Cognitive changes after alcohol cue exposure.
Cooney, N. L., Gillespie, R. A., Baker, L. H., et al. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.55.2.150 · Cited by 104 · see citing works
Cue elicited urge to drink and salivation in alcoholics: Relationship to individual differences
Rohsenow, D. J., Monti, P. M., Abrams, D. B., Rubonis, A. V., NIAURA, R. S., Sirota, A. D., & Colby, S. M. (1992) · Advances in Behaviour Research and Therapy · doi:10.1016/0146-6402(92)90008-c · Cited by 100 · see citing works
Attenuated salivary cortisol secretion under cue exposure is associated with early relapse
JUNGHANNS, K., TIETZ, U., DIBBELT, L., KUETHER, M., JURTH, R., EHRENTHAL, D., BLANK, S., & BACKHAUS, J. (2005) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh107 · Cited by 100 · see citing works
Measelle, J. R., Stice, E., & Springer, D. W. (2006) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.20.3.225 · Cited by 94 · see citing works
Brady, K. T., Back, S. E., Waldrop, A. E., McRae‐Clark, A. L., Anton, R. F., Upadhyaya, H. P., Saladin, M. E., & Randall, P. K. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00097.x · Cited by 89 · see citing works
Altered cortisol response in sober alcoholics: An examination of contributing factors
Bernardy, N. C., King, A. C., Parsons, O. A., & Lovallo, W. R. (1996) · Alcohol · doi:10.1016/0741-8329(96)00043-2 · Cited by 80 · see citing works
Alcohol Craving in Outpatients with Alcohol Dependence: Rate and Clinical Correlates
Yoon, G., Kim, S. W., THURAS, P. D., Grant, J. E., & Westermeyer, J. J. (2006) · Journal of Studies on Alcohol · doi:10.15288/jsa.2006.67.770 · Cited by 74 · see citing works
Salivary cortisol measurements during a medically assisted alcohol withdrawal
Keedwell, P. A., Poon, L., Papadopoulos, A. S., Marshall, E. J., & Checkley, S. A. (2001) · Addiction Biology · doi:10.1080/13556210120056580 · Cited by 68 · see citing works
Psychophysiological Indicators of Craving in Alcoholics: Effects of cue exposure
Laberg, J. C., & Ellertsen, B. (1987) · British Journal of Addiction · doi:10.1111/j.1360-0443.1987.tb00437.x · Cited by 67 · see citing works
Conditioned fear stress induces ethanol-associated place preference in rats
Matsuzawa, S., Suzuki, T., & Misawa, M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01456-8 · Cited by 53 · see citing works
Alcohol Withdrawal: Neuroadaptation and Sensitization
Becker, H. C. (1999) · CNS Spectrums · doi:10.1017/s1092852900011202 · Cited by 52 · see citing works
Hypercortisolism in alcohol dependence and its relation to hippocampal volume loss.
Beresford, T., Arciniegas, D., Alfers, J., Clapp, L., Martin, B., Beresford, H. F., Du, Y. P., Liu, D., Shen, D., Davatzikos, C., et al. (2006) · Journal of Studies on Alcohol · doi:10.15288/jsa.2006.67.861 · Cited by 46 · see citing works
Reactivity to alcohol-relevant beverage and imaginal cues in alcoholics
Payne, T. J., Rychtarik, R. G., Rappaport, N. B., Smith, P. O., Etscheidt, M. A., Brown, T. A., & Johnson, C. A. (1992) · Addictive Behaviors · doi:10.1016/0306-4603(92)90026-r · Cited by 45 · see citing works
Autonomic cardiac abnormalities in alcohol-dependent patients admitted to a psychiatric department
Rechlin, T., Orbes, I., Weis, M., & Kaschka, W. P. (1996) · Clinical Autonomic Research · doi:10.1007/bf02291234 · Cited by 45 · see citing works
Relationships among self-report assessments of craving in binge-drinking university students
Rosenberg, H., & Mazzola, J. J. (2007) · Addictive Behaviors · doi:10.1016/j.addbeh.2007.04.019 · Cited by 44 · see citing works
Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during “abstinence”
Rasmussen, D. D., Wilkinson, C. W., & Raskind, M. A. (2006) · Alcohol · doi:10.1016/j.alcohol.2006.06.007 · Cited by 41 · see citing works
Bär, K., Boettger, M. K., Neubauer, R., Grotelüschen, M., Jochum, T., Baier, V., Sauer, H., & Voss, A. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00191.x · Cited by 40 · see citing works
The Relationship of Stress, Coping, Effect Expectancies and Craving
Grüsser, S. M., Mörsen, C. P., Wölfling, K., & Flor, H. (2006) · European Addiction Research · doi:10.1159/000095813 · Cited by 38 · see citing works
Kutscher, S.-U., Heise, D., Banger, M., Saller, B., Michel, M. C., Gastpar, M., Schedlowski, M., & Exton, M. S. (2002) · Neuropsychobiology · doi:10.1159/000054955 · Cited by 37 · see citing works
Chronic Malignant Pain in Cancer Patients
Landolfi, J. C. (1999) · CNS Spectrums · doi:10.1017/s1092852900012165 · Cited by 34 · see citing works
Shively, C. A., Mietus, J. E., Grant, K. A., Goldberger, A. L., Bennett, A. J., & Willard, S. L. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0709-z · Cited by 32 · see citing works
ALCOHOL CRAVING IN PROBLEM AND OCCASIONAL ALCOHOL DRINKERS
Grüsser, S. M., Mörsen, C. P., & Flor, H. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl035 · Cited by 29 · see citing works
Sinha, R. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80063-x · Cited by 22 · see citing works
Self-citationBernardy, N. C., King, A. C., & Lovallo, W. R. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000085587.00498.38 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904 · see citing works
Self-citationEmotion regulation and mental health: recent findings, current challenges, and future directions
Berking, M., & Wupperman, P. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283503669 · Cited by 836 · see citing works
Stress and the HPA axis: role of glucocorticoids in alcohol dependence
Stephens, M. (2012) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v34.4.11 · Cited by 571 · see citing works
Wiers, R. W., Gladwin, T. E., Hofmann, W., Salemink, E., & Ridderinkhof, K. R. (2013) · Clinical Psychological Science · doi:10.1177/2167702612466547 · Cited by 486 · see citing works
Wise, R. A., & Robble, M. A. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-103337 · Cited by 418 · see citing works
New findings on biological factors predicting addiction relapse vulnerability
Sinha, R. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0224-0 · Cited by 401 · see citing works
Self-citationAddictions neuroclinical assessment: a neuroscience-based framework for addictive disorders
Kwako, L. E., Momenan, R., Litten, R. Z., Koob, G. F., & Goldman, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.024 · Cited by 395 · see citing works
Berking, M., Margraf, M., Ebert, D., Wupperman, P., Hofmann, S. G., & Junghanns, K. (2011) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0023421 · Cited by 395 · see citing works
Sinha, R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.49 · Cited by 368 · see citing works
Self-citationStress-related factors in cannabis use and misuse: Implications for prevention and treatment
Hyman, S. M., & Sinha, R. (2009) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2008.08.005 · Cited by 344 · see citing works
Self-citationPsychosocial and Clinical Predictors of Retention in Outpatient Alcoholism Treatment
Filho, J. M. C., & Baltieri, D. A. (2012) · Brazilian Journal of Psychiatry · doi:10.1016/j.rbp.2012.03.003 · Cited by 343 · see citing works
Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
Becker, J. B., Perry, A. N., & Westenbroek, C. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-14 · Cited by 315 · see citing works
Modeling stress and drug craving in the laboratory: implications for addiction treatment development
Sinha, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00134.x · Cited by 314 · see citing works
Self-citationThe COVID-19 pandemic and its impact on substance use: Implications for prevention and treatment
Ornell, F. R., Moura, H. F., Scherer, J. N., Pechansky, F., Kessler, F. H. P., & DIEMEN, L. V. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113096 · Cited by 312 · see citing works
Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo, D., Lacadie, C., Tuit, K. L., Hong, K., Constable, R. T., & Sinha, R. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.762 · Cited by 302 · see citing works
Self-citationInterrelations between pain and alcohol: an integrative review
Zale, E. L., Maisto, S. A., & Ditre, J. W. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.02.005 · Cited by 291 · see citing works
Brewer, J. A., Sinha, R., Chen, J. A., Michalsen, R. N., Babuscio, T. A., Nich, C., Grier, A., Bergquist, K. L., Reis, D. L., Potenza, M. N., et al. (2009) · Substance Abuse · doi:10.1080/08897070903250241 · Cited by 286 · see citing works
Self-citationHogarth, L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0600-8 · Cited by 281 · see citing works
The role of interoception in addiction: A critical review
Verdejo‐García, A., Clark, L., & Dunn, B. D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.007 · Cited by 270 · see citing works
Breese, G. R., Sinha, R., & Heilig, M. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.007 · Cited by 262 · see citing works
Self-citationAlcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders
Blaine, S. K., & Sinha, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.037 · Cited by 257 · see citing works
“…continued high basal ACTH and cortisol as well as higher basal heart rates, and blunted or suppressed ACTH, cortisol, and heart rate responses to pharmacological and psychological challenges in alcohol dependent individuals (Fox et al., 2008, 2012a; Sinha, 2012; Sinha et al., 2012, 2011a, 2009b).”
Self-citationSharma, S., Fernandes, M. F., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.197 · Cited by 231 · see citing works
Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances
Brower, K. J., & Perron, B. E. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.10.020 · Cited by 226 · see citing works
Sex Differences in the Neurobiology of Alcohol Use Disorder
Flores‐Bonilla, A. (2020) · Alcohol research · doi:10.35946/arcr.v40.2.04 · Cited by 201 · see citing works
Sex differences in neural responses to stress and alcohol context cues
Seo, D., Jia, Z., Lacadie, C., Tsou, K. A., Bergquist, K. L., & Sinha, R. (2010) · Human Brain Mapping · doi:10.1002/hbm.21165 · Cited by 199 · see citing works
Self-citationStress, habits, and drug addiction: A psychoneuroendocrinological perspective.
Schwabe, L., Dickinson, A., & Wolf, O. T. (2011) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0022212 · Cited by 191 · see citing works
Kim, S. M., Han, D. H., Lee, Y. S., & Renshaw, P. F. (2012) · Computers in Human Behavior · doi:10.1016/j.chb.2012.05.015 · Cited by 187 · see citing works
Alcohol Dependence, Withdrawal, and Relapse
Becker, H. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00019-5 · Cited by 184 · see citing works
Schmidt, R. A., Genois, R., Jin, J., Vigo, D., Rehm, J. T., & Rush, B. R. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.109065 · Cited by 175 · see citing works
Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment
Garland, E. L., Franken, I. H. A., & Howard, M. O. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2618-4 · Cited by 170 · see citing works
Addiction as a coping response: hyperkatifeia, deaths of despair, and COVID-19
Koob, G. F., Powell, P., & White, A. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20091375 · Cited by 166 · see citing works
Ali, F., Russell, C., Nafeh, F., Rehm, J. T., LeBlanc, S., & Elton‐Marshall, T. (2021) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2021.103237 · Cited by 165 · see citing works
Kwako, L. E., Spagnolo, P. A., Schwandt, M. L., Thorsell, A., George, D. T., Momenan, R., Rio, D. E., Huestis, M. A., Anizan, S., Concheiro, M., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.306 · Cited by 160 · see citing works
Self-citationFox, H. C., Anderson, G. M., Tuit, K. L., Hansen, J., Kimmerling, A., Siedlarz, K. M., MORGAN, P. T., & Sinha, R. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01628.x · Cited by 157 · see citing works
Self-citationSex Differences in Drug-Related Stress-System Changes
Fox, H. C., & Sinha, R. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902899680 · Cited by 152 · see citing works
Self-citationFox, H. C., D'Sa, C., Kimmerling, A., Siedlarz, K. M., Tuit, K. L., Stowe, R., & Sinha, R. (2012) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.1251 · Cited by 140 · see citing works
Self-citationHow does stress lead to risk of alcohol relapse?
Sinha, R. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.07 · Cited by 147 · see citing works
Self-citationNeurobiology of comorbid post‐traumatic stress disorder and alcohol‐use disorder
Gilpin, N. W., & Weiner, J. L. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12349 · Cited by 147 · see citing works
Effects of Acute Stress on Decision Making
Wemm, S., & Wulfert, E. (2017) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-016-9347-8 · Cited by 147 · see citing works
Stress and substance use disorders: risk, relapse, and treatment outcomes
Sinha, R. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172883 · Cited by 145 · see citing works
Self-citationFox, H. C., Sofuoglu, M., MORGAN, P. T., Tuit, K. L., & Sinha, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.022 · Cited by 143 · see citing works
Self-citationBalodis, I. M., Wynne‐Edwards, K. E., & Olmstead, M. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.011 · Cited by 134 · see citing works
Richards, J. M., Stipelman, B. A., Bornovalova, M. A., Daughters, S. B., Sinha, R., & Lejuez, C. W. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.06.009 · Cited by 132 · see citing works
Self-citationFacets of impulsivity and alcohol use: What role do emotions play?
Herman, A. M., & Duka, T. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.011 · Cited by 131 · see citing works
Bujarski, S. J., Norberg, M. M., & Copeland, J. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.05.014 · Cited by 130 · see citing works
Carlson, V. C. C., Seabold, G. K., Helms, C. M., Garg, N., Odagiri, M., Rau, A. R., Daunais, J. B., Alvarez, V. A., Lovinger, D. M., & Grant, K. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.140 · Cited by 126 · see citing works
Blaine, S. K., Nautiyal, N., Hart, R. L. D., Guarnaccia, J. B., & Sinha, R. (2018) · Addiction Biology · doi:10.1111/adb.12665 · Cited by 125 · see citing works
Self-citationFox, H. C., Morgan, P. T., & Sinha, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.1 · Cited by 122 · see citing works
Self-citationRay, L. A., Bujarski, S., Shoptaw, S., Roche, D. J., Heinzerling, K., & Miotto, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.10 · Cited by 118 · see citing works
Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability
Milivojevic, V., & Sinha, R. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.12.010 · Cited by 118 · see citing works
Self-citationHigley, A. E., Crane, N. A., Spadoni, A. D., Quello, S. B., Goodell, V., & Mason, B. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2355-8 · Cited by 116 · see citing works
Self-regulatory depletion increases emotional reactivity in the amygdala
Wagner, D. D., & Heatherton, T. F. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss082 · Cited by 115 · see citing works
Gender differences in neural correlates of stress-induced anxiety
Seo, D., Ahluwalia, A., Potenza, M. N., & Sinha, R. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23926 · Cited by 114 · see citing works
Self-citationHow emotionally intelligent are pre-service teachers?
Corcoran, R. P., & Tormey, R. (2012) · Teaching and Teacher Education · doi:10.1016/j.tate.2012.02.007 · Cited by 114 · see citing works
Karkhanis (2017) · doi:10.1016/bs.irn.2017.08.001 · Cited by 113 · see citing works
Fox, H. C., Seo, D., Tuit, K., Hansen, J., Kimmerling, A., Morgan, P. T., & Sinha, R. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111430746 · Cited by 112 · see citing works
Self-citationHuang, M. M., Overstreet, D. H., Knapp, D. J., Angel, R. A., Wills, T. A., Navarro, M., Rivier, J., Vale, W., & Breese, G. R. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.159186 · Cited by 111 · see citing works
Habitual Alcohol Seeking: Neural Bases and Possible Relations to Alcohol Use Disorders
Corbit, L. H., & Janak, P. H. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13094 · Cited by 110 · see citing works
Risk-Taking and Impulsivity: The Role of Mood States and Interoception
Herman, A. M., Critchley, H., & Duka, T. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01625 · Cited by 110 · see citing works
Kelly, J. F., Greene, M. C., Bergman, B. G., White, W. L., & Hoeppner, B. B. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14067 · Cited by 107 · see citing works
Stress modulates illness-course of substance use disorders: a translational review
Lijffijt, M., Hu, K., & Swann, A. C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00083 · Cited by 103 · see citing works
Martin‐Fardon, R., & Weiss, F. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_202 · Cited by 101 · see citing works
Neuroclinical Framework for the Role of Stress in Addiction
Kwako, L. E., & Koob, G. F. (2017) · Chronic Stress · doi:10.1177/2470547017698140 · Cited by 99 · see citing works
Emotional arousal and multiple memory systems in the mammalian brain
Packard, M., & Goodman, J. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00014 · Cited by 103 · see citing works
Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression
Neupane, S. P. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00655 · Cited by 97 · see citing works
Heart rate variability in alcohol use: A review
Ralevski, E., Petrakis, I. L., & Altemus, M. M. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.12.003 · Cited by 95 · see citing works
Boness, C. L., Watts, A. L., Moeller, K. N., & Sher, K. J. (2021) · Psychological Bulletin · doi:10.1037/bul0000333 · Cited by 95 · see citing works
Inducing Negative Affect Increases the Reward Value of Appetizing Foods in Dieters
Wagner, D. D., Boswell, R. G., Kelley, W. M., & Heatherton, T. F. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00238 · Cited by 95 · see citing works
The neurobiology of alcohol craving and relapse
Seo, D., & Sinha, R. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00021-5 · Cited by 94 · see citing works
Self-citationBresin, K., Mekawi, Y., & Verona, E. (2018) · Psychology of Addictive Behaviors · doi:10.1037/adb0000383 · Cited by 90 · see citing works
Evidence for incentive salience sensitization as a pathway to alcohol use disorder
Cofresí, R. U., Bartholow, B. D., & Piasecki, T. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.009 · Cited by 90 · see citing works
The Importance of Glucocorticoids in AlcoholDependence and Neurotoxicity
Rose, A. K., Shaw, S., Prendergast, M., & Little, H. J. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01298.x · Cited by 87 · see citing works
Garland, E. L., Franken, I. H. A., Sheetz, J. J., & Howard, M. O. (2012) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0027199 · Cited by 84 · see citing works
Pharmacological approaches to reducing craving in patients with alcohol use disorders
Haass-Koffler, C. L., Leggio, L., & Kenna, G. A. (2014) · CNS Drugs · doi:10.1007/s40263-014-0149-3 · Cited by 83 · see citing works
An acute psychosocial stressor increases drinking in non-treatment-seeking alcoholics
Thomas, S. E., Bacon, A. K., Randall, P. K., Brady, K. T., & See, R. E. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2163-6 · Cited by 83 · see citing works
Mitchell, J. M., Arcuni, P. A., Weinstein, D., & Woolley, J. D. (2016) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000213 · Cited by 82 · see citing works
Ray, L. A. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01333.x · Cited by 81 · see citing works
Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals
McRae‐Clark, A. L., Carter, R. E., Price, K. L., Baker, N. L., Thomas, S., Saladin, M. E., Giarla, K., Nicholas, K. S., & Brady, K. T. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2376-3 · Cited by 78 · see citing works
Lu, Y.-L., & Richardson, H. N. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.053 · Cited by 78 · see citing works
Barbadoro, P., Annino, I., Ponzio, E., Romanelli, R. M. L., D’Errico, M. M., Prospero, E., & Minelli, A. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200676 · Cited by 76 · see citing works
Boschloo, L., Vogelzangs, N., Licht, C. M. M., Vreeburg, S. A., Smit, J. H., van den Brink, W., Veltman, D. J., de Geus, E. J. C., Beekman, A. T. F., & Penninx, B. W. J. H. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.12.006 · Cited by 73 · see citing works
Kufahl, P. R., Martin-Fardon, R., & Weiss, F. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.174 · Cited by 72 · see citing works
Long term structural and functional neural changes following a single infusion of Ketamine in PTSD
Duek, O. A., Korem, N., Li, Y., Kelmendi, B., Amen, S. L., Gordon, C., Milne, M., Krystal, J. H., Levy, I., & Harpaz‐Rotem, I. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01606-3 · Cited by 71 · see citing works
Maffei, C., Cavicchioli, M., Movalli, M., Cavallaro, R., & Fossati, A. (2018) · Substance Use & Misuse · doi:10.1080/10826084.2018.1480035 · Cited by 62 · see citing works
Hellberg, S. N., Russell, T. I., & Robinson, M. J. F. (2019) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-018-00662-3 · Cited by 65 · see citing works
“These responses to stress cues were on the whole comparable to those induced by alcohol-associated cues (Fox et al., 2007; Sinha et al., 2009; Sinha & Li, 2007), and support the evidence that the physiological reactivity elicited by stress cues may serve as a powerful catalyst for craving and…”
Wemm, S., Larkin, C., Hermes, G., Tennen, H. A., & Sinha, R. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107569 · Cited by 65 · see citing works
Self-citationXu, K., Seo, D., Hodgkinson, C. A., Hu, Y., Goldman, D. A., & Sinha, R. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.62 · Cited by 63 · see citing works
Self-citationSystematic review of the effects of acute stress in binge eating disorder
Naish, K. R., Laliberte, M. M., MacKillop, J. M., & Balodis, I. M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14110 · Cited by 63 · see citing works
Addictions Neuroclinical Assessment: A reverse translational approach
Kwako, L. E., Momenan, R., Grodin, E. N., Litten, R. Z., Koob, G. F., & Goldman, D. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.006 · Cited by 62 · see citing works
Hogarth, L., Hardy, L., Mathew, A. R., & Hitsman, B. L. (2018) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000177 · Cited by 61 · see citing works
Knapp, D. J., Whitman, B. A., Wills, T. A., Angel, R. A., Overstreet, D. H., Criswell, H. E., Ming, Z., & Breese, G. R. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.02.018 · Cited by 60 · see citing works
Murphy, A., Taylor, E., & Elliott, R. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00101 · Cited by 60 · see citing works
Alcohol Effects on Stress Pathways
Blaine, S. K., Milivojevic, V., Fox, H. C., & Sinha, R. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716632512 · Cited by 60 · see citing works
Self-citationSelf-regulation and its failure: The seven deadly threats to self-regulation.
Wagner, D. D., & Heatherton, T. F. (2014) · American Psychological Association eBooks · doi:10.1037/14341-026 · Cited by 60 · see citing works
Pati, D., Marcinkiewcz, C. A., DiBerto, J. F., Cogan, E. S., McElligott, Z. A., & Kash, T. L. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107759 · Cited by 59 · see citing works
Fox, H. C., Hong, K.-I. A., Siedlarz, K. M., Bergquist, K. L., Anderson, G. M., Kreek, M. J., & Sinha, R. (2009) · Alcohol and Alcoholism · doi:10.1093/alcalc/agp060 · Cited by 59 · see citing works
Self-citationMcCloskey, M. S., Look, A. E., Chen, E. Y., Pajoumand, G., & Berman, M. E. (2012) · Suicide and Life-Threatening Behavior · doi:10.1111/j.1943-278x.2012.00082.x · Cited by 58 · see citing works
Divergent regulation of distinct glucocorticoid systems in alcohol dependence
Edwards, S., Little, H. J., Richardson, H. N., & Vendruscolo, L. F. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.04.004 · Cited by 56 · see citing works
Zandberg, L. J., Rosenfield, D., McLean, C. P., Powers, M. B., Asnaani, A., & Foa, E. B. (2015) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000052 · Cited by 56 · see citing works
Blunted vagal reactivity predicts stress-precipitated tobacco smoking
Ashare, R. L., Sinha, R., Lampert, R. J., Weinberger, A. H., Anderson, G. M., Lavery, M. E., Yanagisawa, K., & McKee, S. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2473-3 · Cited by 55 · see citing works
Self-citation
- Authors
- Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M.
- Affiliations
- Yale University (US)
- Venue
- Neuropsychopharmacology
- Published
- 2008-06-18
- Volume
- 34
- Issue
- 5
- Pages
- 1198-1208
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC2734452
- OpenAlex
- W2105130852
- Cited by
- 466
- References
- 87
- Citations by year
- 2026: 15 · 2025: 35 · 2024: 25 · 2023: 26 · 2022: 20 · 2021: 33 · 2020: 23 · 2019: 29 · 2018: 38 · 2017: 28 · 2016: 29 · 2015: 29 · 2014: 30 · 2013: 15 · 2012: 41
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University
- Deutsches Krebsforschungszentrum
- Georgia Clinical and Translational Science Alliance (UL1 RR024139)
- National Institutes of Health (1ul1rr024925-01)
- National Institute on Alcohol Abuse and Alcoholism (R0I-AA13892, R01AA013892)
- National Institute on Drug Abuse (K02 DA17232, K02DA017232, PL1DA024859)
- National Center for Research Resources (UL1-RR024925, UL1-RR24925, RR024139, UL1RR024139)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- alcoholism, alcohol craving, negative emotions, stress response, alcohol cue exposure, guided imagery, salivary cortisol, heart rate, blood pressure, HPA axis dysregulation, anxiety, relapse, abstinence, social drinkers
- MeSH terms
- Adult, Blood Pressure, Cues, Data Interpretation, Statistical, Emotions, Female, Heart Rate, Humans, Hydrocortisone, Male, Middle Aged, Saliva, Stress, Psychological, Behavior, Addictive, Alcohol-Related Disorders, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review