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Human prefrontal lesions increase distractibility to irrelevant sensory inputs
Abstract
Neurological patients with focal lesions in either the dorsolateral prefrontal cortex, temporal-parietal junction or the posterior hippocampus, and control subjects, were tested on a task requiring short-term retention of environmental sounds. Subjects had to indicate whether initial and subsequent test sounds were identical in two conditions. The initial and test sounds were separated by either a silent period varying from 4 to 12.6 s (no-distractor condition) or a series of irrelevant tones (distractor condition). Prefrontal patients were significantly impaired by distractors at all delays, hippocampal patients were impaired only at longer delays, while temporal-parietal patients performed similar to controls. The findings suggest that dorsolateral prefrontal cortex is crucial for gating of distracting information during delay tasks.
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Metadata
- Authors
- Chao, L. L., & Knight, R. T.
- Venue
- NeuroReport
- Published
- 1995-08
- Volume
- 6
- Issue
- 12
- Pages
- 1605-1610
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2045867144
- Cited by
- 265
- References
- 0
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
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