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Cited by 46Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

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5.4 Dopaminergic Modulation of Flexible Cognitive Control in Humans

Cools, Roshan, D’Esposito, Mark·2009·Dopamine Handbook
DOI 10.1093/acprof:oso/9780195373035.003.0017
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Abstract

This chapter highlights the importance for cognitive control not only of the prefrontal cortex (PFC), but also of the striatum, which has been traditionally associated primarily with movement control. It elaborates on a previously proposed working hypothesis, which states that the balance between cognitive flexibility and stability depends on an adjustment of processing in circuits connecting the PFC with the striatum by the neurotransmitter dopamine (DA).

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  1. Fuster, 1989, The Prefrontal Cortex
  2. Miller, 2001, An integrative theory of prefrontal cortex function., Annu Rev Neurosci., 10.1146/annurev.neuro.24.1.167 · DOI · Paper page
  3. Chao, 1995, Human prefrontal lesions increase distractibility to irrelevant sensory inputs., Neuroreport., 10.1097/00001756-199508000-00005 · DOI
  4. Miller, 2005, Searching for “the top” in top-down control., Neuron., 10.1016/j.neuron.2005.11.002 · DOI
  5. Robbins, 2000, Chemical neuromodulation of frontal-executive functions in humans and other animals., Exp Brain Res., 10.1007/s002210000407 · DOI
  6. Arnsten, 1998, Catecholamine modulation of prefrontal cortical cognitive function., Trends Cogn Sci., 10.1016/S1364-6613(98)01240-6 · DOI
  7. Frank, 2001, Interactions between frontal cortex and basal ganglia in working memory: a computational model., Cogn Affect Behav Neurosci., 10.3758/CABN.1.2.137 · DOI · Paper page
  8. Cools, 2004, Chemistry of the adaptive mind., Philos Transact A Math Phys Eng Sci., 10.1098/rsta.2004.1468 · DOI · Paper page
  9. Cools, 2006, Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease., Neurosci Biobehav Rev., 10.1016/j.neubiorev.2005.03.024 · DOI · Paper page
  10. Kramer, 2001, Methylphenidate effects on task-switching performance in attention-deficit/hyperactivity disorder., J Am Acad Child Adolesc Psychiatry., 10.1097/00004583-200111000-00007 · DOI
  11. Wilder, 1957, Paradoxic reactions to treatment., NY State J Med.
  12. Dews, 1977, Rate-dependency hypothesis., Science., 10.1126/science.563103 · DOI
  13. Dews, 1958, Studies on behavior. IV. Stimulant actions of methamphetamine., J Pharmacol Exp Ther.
  14. Kimberg, 1997, Effects of bromocriptine on human subjects depend on working memory capacity., Neuroreport., 10.1097/00001756-199711100-00032 · DOI · Paper page
  15. Granon, 2000, Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex., J Neurosci., 10.1523/JNEUROSCI.20-03-01208.2000 · DOI · Paper page
  16. Mattay, 2000, Effects of dextroamphetamine on cognitive performance and cortical activation., Neuroimage., 10.1006/nimg.2000.0610 · DOI · Paper page
  17. Baddeley, 1986, Working Memory
  18. Sawaguchi, 1990, Effects of dopamine antagonists on neuronal activity related to a delated response task in monkey prefrontal cortex., J Neurophysiol.
  19. Sawaguchi, 1990, Catecholaminergic effects on neuronal activity related to a delayed response task in monkey prefrontal cortex., J Neurophysiol.
  20. Luciana, 1998, Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions., Cereb Cortex., 10.1093/cercor/8.3.218 · DOI
  21. Luciana, 1997, Dopaminergic modulation of working memory for spatial but not object cues in normal volunteers., J Cogn Neurosci., 10.1162/jocn.1997.9.3.330 · DOI
  22. Luciana, 1992, Facilitation of working memory in humans by a D2 dopamine receptor agonist., J Cogn Neurosci., 10.1162/jocn.1992.4.1.58 · DOI
  23. Daneman, 1980, Individual differences in working memory and reading., J Verbal Learn Verbal Behav., 10.1016/S0022-5371(80)90312-6 · DOI · Paper page
  24. Salthouse, 1991, Decomposing adult age differences in working memory., Dev Psychol., 10.1037/0012-1649.27.5.763 · DOI · Paper page
  25. Kimberg, 2003, Cognitive effects of the dopamine receptor agonist pergolide., Neuropsychologia., 10.1016/S0028-3932(02)00317-2 · DOI
  26. Cools, 2007, Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory., J Neurosci., 10.1523/JNEUROSCI.0601-07.2007 · DOI
  27. Gibbs, 2005, Individual capacity differences predict working memory performance and prefrontal activity following dopamine receptor stimulation., Cogn Affect Behav Neurosci., 10.3758/CABN.5.2.212 · DOI · Paper page
  28. Frank, 2006, A mechanistic account of striatal dopamine function in human cognition: psychopharmacological studies with cabergoline and haloperidol., Behav Neurosci., 10.1037/0735-7044.120.3.497 · DOI · Paper page
  29. Mehta, 2000, Amelioration of specific working memory deficits by methylphenidate in a case of adult attention deficit/hyperactivity disorder., J Psychopharmacol., 10.1177/026988110001400314 · DOI
  30. Phillips, 2004, Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task., J Neurosci., 10.1523/JNEUROSCI.4653-03.2004 · DOI
  31. Zahrt, 1997, Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance., J Neurosci., 10.1523/JNEUROSCI.17-21-08528.1997 · DOI · Paper page
  32. Floresco, 2001, Delay-dependent modulation of memory retrieval by infusion of a dopamine D1 agonist into the rat medial prefrontal cortex., Behav Neurosci., 10.1037/0735-7044.115.4.934 · DOI
  33. Cools, 2009, Striatal dopamine synthesis capacity predicts dopaminergic drug effects on flexible outcome learning., J Neurosci., 10.1523/JNEUROSCI.4467-08.2009 · DOI
  34. Collins, 1998, Perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex., J Cogn Neurosci., 10.1162/089892998562771 · DOI
  35. Crofts, 2001, Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set., Cereb Cortex., 10.1093/cercor/11.11.1015 · DOI · Paper page
  36. Mehta, 2004, Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers., Psychopharmacology., 10.1007/s00213-004-1899-2 · DOI
  37. Nolan, 2004, Am J Psychiaty., 10.1176/appi.ajp.161.2.359 · DOI
  38. Lotta, 1995, Biochemistry., 10.1021/bi00013a008 · DOI
  39. Chen, 2004, Am J Genet., 10.1086/425589 · DOI · Paper page
  40. Druzin, 2000, Behav Brain Res., 10.1016/S0166-4328(99)00166-7 · DOI · Paper page
  41. Durstewitz, 2008, Biol Psychiatry., 10.1016/j.biopsych.2008.05.015 · DOI · Paper page
  42. Seamans, 2004, The principal features and mechanisms of dopamine modulation in the prefrontal cortex., Prog Neurobiol., 10.1016/j.pneurobio.2004.05.006 · DOI · Paper page
  43. Frank, 2004, By carrot or by stick: cognitive reinforcement learning in parkinsonism., Science., 10.1126/science.1102941 · DOI · Paper page
  44. Cools, 2006, Reversal learning in Parkinson's disease depends on medication status and outcome valence., Neuropsychologia., 10.1016/j.neuropsychologia.2006.03.030 · DOI
  45. Durstewitz, 2000, Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex., J Neurophysiol., 10.1152/jn.2000.83.3.1733 · DOI
  46. Frank, 2005, Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism., J Cogn Neurosci., 10.1162/0898929052880093 · DOI · Paper page
  47. Zhang, 2007, Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory., Proc Natl Acad Sci USA., 10.1073/pnas.0707106104 · DOI
  48. Meyer-Lindenberg, 2007, Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition., J Clin Invest., 10.1172/JCI30413 · DOI
  49. Gruber, 2006, Dopamine modulation in the basal ganglia locks the gate to working memory., J Comput Neurosci., 10.1007/s10827-005-5705-x · DOI
  50. Leber, 2008, Neural predictors of moment-to-moment fluctuations in cognitive flexibility., Proc Natl Acad Sci USA., 10.1073/pnas.0805423105 · DOI
  51. Cools, 1980, Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: facilitation of processes involved in selecting the best strategy in a stressful situation., Behav Brain Res., 10.1016/0166-4328(80)90035-2 · DOI · Paper page
  52. Lyon, 1975, Current Developments in Psychopharmacology,
  53. Pycock, 1980, Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats., Nature., 10.1038/286074a0 · DOI
  54. Akil, 2003, J Neurosci.
  55. Bertolino, 2006, Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain., J Neurocsci., 10.1523/JNEUROSCI.4975-05.2006 · DOI
  56. Caldu, 2007, Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects., Neuroimage., 10.1016/j.neuroimage.2007.06.021 · DOI
  57. Cools, 2002, Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging., J Neurosci., 10.1523/JNEUROSCI.22-11-04563.2002 · DOI · Paper page
  58. Cools, 2001, Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands., Cereb Cortex., 10.1093/cercor/11.12.1136 · DOI · Paper page
  59. Cools, 2007, L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease., Neuropsychopharmacology., 10.1038/sj.npp.1301153 · DOI
  60. Sawamoto, 2008, Cognitive deficits and striato-frontal dopamine release in Parkinson's disease., Brain, 10.1093/brain/awn054 · DOI
  61. Agid, 1993, Are dopaminergic neurons selectively vulnerable to Parkinson's disease?, Adv Neurol.
  62. Rakshi, 1999, Frontal, midbrain and striatal dopamergic function in early and advanced Parkinson's disease. A 3D [(18)F]dopa-PET study., Brain., 10.1093/brain/122.9.1637 · DOI
  63. Kaasinen, 2001, Increased frontal [(18)F]fluorodopa uptake in early Parkinson's disease: sex differences in the prefrontal cortex., Brain., 10.1093/brain/124.6.1125 · DOI
  64. Bowen, 1975, Parkinsonism: effects of levodopa treatment on concept formation., Neurology., 10.1212/WNL.25.8.701 · DOI
  65. Lees, 1983, Cognitive deficits in the early stages of Parkinson's disease., Brain., 10.1093/brain/106.2.257 · DOI
  66. Taylor, 1995, The neuropsychology of Parkinson's disease., Brain Cogn., 10.1006/brcg.1995.1258 · DOI
  67. Cools, 1984, Cognitive and motor shifting aptitude disorder in Parkinson's disease., J Neurol Neurosurg Psychiatry., 10.1136/jnnp.47.5.443 · DOI
  68. Downes, 1989, Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction., Neuropsychologia., 10.1016/0028-3932(89)90128-0 · DOI · Paper page
  69. Owen, 1992, Fronto-striatal cognitive deficits at different stages of Parkinson's disease., Brain., 10.1093/brain/115.6.1727 · DOI
  70. Owen, 1995, Dopamine-dependent frontostriatal planning deficits in early Parkinson's disease., Neuropsychology., 10.1037/0894-4105.9.1.126 · DOI
  71. Pollux, 2002, Reduced task-set inertia in Parkinson's disease., J Clin Exp Neuropsychol., 10.1076/jcen.24.8.1046.8374 · DOI
  72. Pollux, 2004, Advance preparation of set-switches in Parkinson's disease., Neuropsychologia., 10.1016/j.neuropsychologia.2003.12.002 · DOI
  73. Rogers, 1998, Dissociating executive mechanisms of task control following frontal lobe damage and Parkinson's disease., Brain., 10.1093/brain/121.5.815 · DOI · Paper page
  74. Cools, 2001, Mechanisms of cognitive set flexibility in Parkinson's disease., Brain., 10.1093/brain/124.12.2503 · DOI · Paper page
  75. Hayes, 1998, Towards a functional analysis of the basal ganglia., J Cogn Neurosci., 10.1162/089892998562645 · DOI
  76. Cools, 2003, L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease., Neuropsychologia., 10.1016/S0028-3932(03)00117-9 · DOI · Paper page
  77. Gerlach, 2003, Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum., J Neural Transm., 10.1007/s00702-003-0027-5 · DOI
  78. De, 1995, Dopamine agonists used in the treatment of Parkinson's disease and their selectivity for the D1, D2, and D3 dopamine receptors in human striatum., Prog Neuropsychopharmacol Biol Psychiatry., 10.1016/0278-5846(95)00232-4 · DOI

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Metadata

Authors
Cools, R., & D’Esposito, M.
ORCID
Venue
Dopamine Handbook
Publisher
Oxford University PressNew York
Published
2009-10-16
Pages
249-260
DOI
10.1093/acprof:oso/9780195373035.003.0017
OpenAlex
W822120244
Cited by
46
References
15
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 4
FWCI
3.82
Type
book chapter
Language
en
Open access
closed
Locations
Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
dopamine, cognitive control, cognitive flexibility, cognitive stability, prefrontal cortex, striatum, dopaminergic modulation

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