Nicotine withdrawal in the rat: role of α7 nicotinic receptors in the ventral tegmental area
Abstract
Previous data show that nicotinic receptors in the ventral tegmental area are of importance for the nicotine withdrawal syndrome. Here we have investigated the specific role of alpha7 nicotinic receptors in the ventral tegmental area for the neurobiological and behavioral consequences of nicotine withdrawal. Rats were exposed to nicotine for 14 days via s.c. osmotic minipumps. Bilateral intrategmental injections of the selective alpha7 nicotinic receptor antagonist methyllycaconitine reduced locomotion in the nicotine-treated rats, but not in control animals. Unilateral intrategmental injection of methyllycaconitine reduced dopamine output in the ipsilateral nucleus accumbens of nicotine-treated rats, but not in controls. Our results indicate that alpha7 nicotinic receptors in the ventral tegmental area are involved in the nicotine withdrawal syndrome.
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The a7 subtype has been implicated in generalized nicotine withdrawal syndrome.
“ABT-107 is selective for the a7 subtype (Malysz et al., 2010) that has been implicated in generalized nicotine withdrawal syndrome (Nomikos et al., 1999).”
From Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors (2014) · cites this paper as Nomikos et al., 1999
a7 nAChRs are necessary in the ventral tegmental area for the expression of withdrawal from nicotine.
“Furthermore, although a7 nAChRs have not been implicated directly in anxiety (Paylor et al., 1998;Vicens et al., 2011) they are necessary in the ventral tegmental area for the expression of withdrawal from nicotine, suggesting that targeting of the a7 subtype may also relieve nicotine withdrawal symptoms (Nomikos et al., 1999).”
From Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors (2014) · cites this paper as Nomikos et al., 1999
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- Authors
- Nomikos, G. G., Hildebrand, B. E., Panagis, G., & Svensson, T. H.
- Affiliations
- Eli Lilly (United States) (US)
- Karolinska Institutet (SE)
- ORCID
- Nomikos, George G.
- Venue
- Neuroreport
- Published
- 1999-03
- Volume
- 10
- Issue
- 4
- Pages
- 697-702
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2109108702
- Cited by
- 45
- References
- 10
- Citations by year
- 2022: 1 · 2021: 1 · 2018: 1 · 2016: 3 · 2014: 3 · 2013: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine withdrawal, alpha7 nicotinic acetylcholine receptor, ventral tegmental area, methyllycaconitine, dopamine release, nucleus accumbens, locomotor activity, nicotine dependence
- MeSH terms
- Animals, Dopamine, Homovanillic Acid, Male, Microinjections, Motor Activity, Nicotine, Nucleus Accumbens, Receptors, Nicotinic, Substance Withdrawal Syndrome, 3,4-Dihydroxyphenylacetic Acid, Rats, Wistar, Microdialysis, Ventral Tegmental Area, Nicotinic Agonists, Rats, alpha7 Nicotinic Acetylcholine Receptor
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