Cited by 89Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudyPrenatal Substance Exposure Effects

Rodent models of nicotine withdrawal syndrome

Malin, David H., Goyarzu, Pilar·2009·Handbook of experimental pharmacology

Abstract

Simple, rapid and inexpensive rodent models of nicotine physical dependence and withdrawal syndrome have proved useful for preliminary screening of smoking cessation treatments. They have led to an exponential increase of knowledge regarding the underlying neurobiological mechanisms of dependence and withdrawal syndrome. The human nicotine withdrawal syndrome in smoking cessation is variable and multidimensional, involving irritability, anxiety, depression, cognitive and attentional impairments, weight gain, sleep disturbances, and craving for nicotine. Aside from sleep disturbances, analogous phenomena have been seen in rodent models using different measures of withdrawal intensity. It appears likely that different withdrawal phenomena may involve some partially divergent mechanisms. For example, depression-like phenomena may involve alterations in mechanisms such as the mesolimbic dopamine pathway from the ventral tegmental area to the nucleus accumbens. Irritability and anxiety may involve alterations in endogenous opioid systems and other regions, such as the amygdala. This chapter reviews many additional anatomical, neurochemical, and developmental elements that impact nicotine physical dependence.

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Crossref · 10.1007/978-3-540-69248-5_14

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  • Rodents chronically exposed to nicotine undergo a characteristic withdrawal syndrome that can occur spontaneously or be precipitated by mecamylamine.

    “Rodents chronically exposed to nicotine undergo a characteristic withdrawal syndrome which develops spontaneously, after removing the nicotine source, or can be precipitated by administration of a nAChR antagonist such as mecamylamine [7, 11, 81, 163–166].”

    From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [166]

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Authors
Malin, D. H., & Goyarzu, P.
Affiliations
University of Houston - Clear Lake (US)
Corresponding author
Malin, David H.
Venue
Handbook of experimental pharmacology
Published
2009
Issue
192
Pages
401-434
ISSN
0171-2004 (ISSN-L)
OpenAlex
W180320970
Cited by
89
References
151
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 23 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 4
FWCI
16.56
Type
book chapter
Language
en
Open access
closed
Locations
  • Handbook of experimental pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
nicotine withdrawal, rodent models, smoking cessation, nicotine craving, sleep disorders, depression-like behavior, anxiety, irritability, mesolimbic dopamine system, ventral tegmental area, nucleus accumbens, endogenous opioid system, amygdala
MeSH terms
Animals, Disease Models, Animal, Nicotine, Severity of Illness Index, Smoking, Substance Withdrawal Syndrome, Tobacco Use Disorder, Gene Expression, Smoking Cessation, Nicotinic Agonists, Mice, Rats, Validation Studies as Topic

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