Body mass predicts orbitofrontal activity during visual presentations of high-calorie foods
Abstract
Little is known about the relationship between weight status and reward-related brain activity in normal weight humans. We correlated orbitofrontal and anterior cingulate cortex activity as measured by functional magnetic resonance imaging with body mass index in 13 healthy, normal-weight adult women as they viewed images of high-calorie and low-calorie foods, and dining-related utensils. Body mass index correlated negatively with both cingulate and orbitofrontal activity during high-calorie viewing, negatively with orbitofrontal activity during low-calorie viewing, and positively with orbitofrontal activity during presentations of nonedible utensils. With greater body mass, activity was reduced in brain regions important for evaluating and modifying learned stimulus-reward associations, suggesting a relationship between weight status and responsiveness of the orbitofrontal cortex to rewarding food images.
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Compared with normal-weight individuals, obese individuals presented with pictures of high-calorie food show increased neural activation in reward and motivation circuits including NAc, dorsal striatum, OFC, ACC, amygdala, hippocampus, and insula.
“compared with normal-weight individuals, obese individuals who were presented with pictures of high-calorie food (stimuli to which they are conditioned) showed increased neural activation in regions that are part of reward and motivation circuits (NAc, dorsal striatum, OFC, ACC, amygdala, hippocampus and insula) (90).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [90]
Compared with normal-weight individuals, obese individuals viewing high-calorie food pictures show increased activation in reward and motivation circuits (NAc, dorsal striatum, OFC, ACC, amygdala, hippocampus, insula).
“Compared with normal-weight individuals, obese individuals observing pictures of high-calorie food (stimuli to which they are conditioned) showed increased activation in regions of the reward and motivation circuits (NAc, dorsal striatum, orbitofrontal cortex [OFC], anterior cingulate cortex [ACC], amygdala, hippocampus, and insula) (50).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [50]
Compared with normal-weight individuals, obese individuals presented with pictures of high-calorie food showed increased neural activation in regions that are part of reward and motivation circuits, including NAc, dorsal striatum, OFC, ACC, amygdala, hippocampus and insula.
“Similarly, compared with normal-weight individuals, obese individuals who were presented with pictures of high-calorie food (stimuli to which they are conditioned) showed increased neural activation in regions that are part of reward and motivation circuits (NAc, dorsal striatum, OFC, ACC, amygdala, hippocampus and insula) (Killgore and Yurgelun-Todd 2005).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Killgore and Yurgelun-Todd 2005
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“We did not find amygdala or OFC activation to food images in AN as shown in other studies (Ellison et al., 1998; Uher et al., 2003, 2004; Killgore and Yurgelun-Todd, 2005; Goldstone et al., 2009; Siep et al., 2009).”
ResultFood Perception and Categorization
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- Authors
- Killgore, W. D. S., & Yurgelun-Todd, D. A.
- Affiliations
- Harvard University (US)
- Venue
- NeuroReport
- Published
- 2005-05
- Volume
- 16
- Issue
- 8
- Pages
- 859-863
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2075366343
- Cited by
- 104
- References
- 24
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 13 · 2013: 15 · 2012: 10
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1 R03 HD41542-01, R03HD041542)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- body mass index, weight status, orbitofrontal cortex, anterior cingulate cortex, food reward, dining utensils, stimulus-reward associations, normal-weight women, brain activity
- MeSH terms
- Adult, Appetite, Brain Mapping, Cerebral Cortex, Female, Food, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Oxygen, Reference Values, Visual Perception, Body Mass Index, Linear Models
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