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Cited by 218Regulation of Appetite and ObesityEating Disorders and BehaviorsNeural and Behavioral Psychology Studies

Brain activity in hunger and satiety: an exploratory visually stimulated fMRI study

Führer, Dagmar, Zysset, Stefan, Stumvoll, Michael·2008·Obesity
DOI 10.1038/oby.2008.33
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Abstract

OBJECTIVE: To explore neuroanatomical sites of eating behavior, we have developed a simple functional magnetic resonance imaging (fMRI) paradigm to image hunger vs. satiety using visual stimulation. METHODS AND PROCEDURES: Twelve healthy, lean, nonsmoking male subjects participated in this study. Pairs of food-neutral and food-related pictures were presented in a block design, after a 14-h fast and 1 h after ad libitum ingestion of a mixed meal. Statistically, a general linear model for serially autocorrelated observations with a P level<0.001 was used. RESULTS: During the hunger condition, significantly enhanced brain activity was found in the left striate and extrastriate cortex, the inferior parietal lobe, and the orbitofrontal cortices. Stimulation with food images was associated with increased activity in both insulae, the left striate and extrastriate cortex, and the anterior midprefrontal cortex. Nonfood images were associated with enhanced activity in the right parietal lobe and the left and right middle temporal gyrus. A significant interaction in activation pattern between the states of hunger and satiety and stimulation with food and nonfood images was found for the left anterior cingulate cortex, the superior occipital sulcus, and in the vicinity of the right amygdala. DISCUSSION: These preliminary data from a homogenous healthy male cohort suggest that central nervous system (CNS) activation is not only altered with hunger and satiety but that food and nonfood images have also specific effects on regional brain activity if exposure takes place in different states of satiety. Wider use of our or a similar approach would help to establish a uniform paradigm to map hunger and satiety to be used for further experiments.

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  • Experimentally manipulated caloric deprivation increases responsivity of brain regions implicated in attention and reward to food images.

    “Yet, experimentally manipulated caloric deprivation increases responsivity of brain regions implicated in attention and reward to food images”

    From Caloric deprivation increases responsivity of attention and reward brain regions to intake, anticipated intake, and images of palatable foods (2013) · cites this paper as Fuhrer et al., 2008

  • fMRI experiments indicate that activation in attention, reward valuation, memory, and homeostatic feeding regions is significantly greater in response to pictures of palatable foods versus non-food control images after caloric deprivation versus a no deprivation condition.

    “activation in regions that have been implicated in attention (anterior cingulate cortex), reward valuation (amygdala), memory (hippocampus), and homeostatic feeding (hypothalamus) was significantly greater in response to pictures of palatable foods versus non-food control images after caloric deprivation versus a no deprivation condition”

    From Caloric deprivation increases responsivity of attention and reward brain regions to intake, anticipated intake, and images of palatable foods (2013) · cites this paper as Fuhrer et al., 2008

  • The evidence that elective caloric restriction in the present studies was associated with greater responsivity of attention and reward regions to palatable food images, anticipated receipt of palatable food, and receipt of palatable food extends findings from caloric deprivation experiments.

    “The evidence that elective caloric restriction in the present studies was associated with greater responsivity of attention and reward regions to palatable food images, anticipated receipt of palatable food, and receipt of palatable food more broadly extend findings from caloric deprivation experiments.”

    From Caloric deprivation increases responsivity of attention and reward brain regions to intake, anticipated intake, and images of palatable foods (2013) · cites this paper as Fuhrer et al., 2008

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Authors
Führer, D., Zysset, S., & Stumvoll, M.
Affiliations
  • Leipzig University (DE)
  • Max Planck Institute for Human Cognitive and Brain Sciences (DE)
Venue
Obesity
Publisher
Wiley
Published
2008-05
Volume
16
Issue
5
Pages
945-950
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
DOI
10.1038/oby.2008.33
OpenAlex
W2055859290
Cited by
218
References
45
Citations by year
2026: 7 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 18 · 2018: 9 · 2017: 19 · 2016: 18 · 2015: 16 · 2014: 10 · 2013: 13 · 2012: 20
FWCI
7.13
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1589 d)
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
hunger, satiety, dietary habits, food images, visual stimulation, brain activity, primary visual cortex, extrastriate cortex, insula, orbitofrontal cortex, anterior cingulate cortex, amygdala
MeSH terms
Adult, Amygdala, Body Weight, Brain, Brain Mapping, Gyrus Cinguli, Humans, Hunger, Magnetic Resonance Imaging, Male, Photic Stimulation, Satiation, Linear Models

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