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Cited by 319

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Chemokines and receptors in HIV encephalitis

Sanders, Virginia J., Pittman, Christopher A., White, Michael G., Wang, Guoji, Wiley, Clayton A., Achim, Cristian L.·1998·AIDS
DOI 10.1097/00002030-199809000-00009
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Abstract

BACKGROUND: Three phenotypes of the antioxidant protein haptoglobin are known: Hp 1-1, Hp 2-1 and Hp 2-2. OBJECTIVES: To investigate the outcome of HIV infection according to haptoglobin type. DESIGN AND METHODS: Haptoglobin phenotypes were determined using starch gel electrophoresis in serum obtained from 653 HIV-infected Caucasians in the AIDS reference centers of Gent (n = 184), Antwerp (n = 309), and Luxembourg (n = 160). Survival was compared between haptoglobin types using Kaplan-Meier curves. Plasma HIV-1 RNA was quantified by reverse transcriptase PCR. Serum iron, transferrin saturation, ferritin, and vitamin C were assayed to evaluate iron-driven oxidative stress in 184 HIV-infected patients and 204 controls. RESULTS: The haptoglobin type distribution amongst the patients (17.6% Hp 1-1, 49.9% Hp 2-1, 32.5% Hp 2-2) corresponded to that of the controls. Kaplan-Meier curves showed a higher mortality for the Hp 2-2 group (P = 0.0001; adjusted mortality risk ratio, 1.78; 95% confidence interval, 1.25-2.54). Median survival time was 11.0 years (Hp 1-1 and Hp 2-1) versus 7.33 years (Hp 2-2). Plasma HIV-1 RNA levels prior to antiviral therapy and their increase over 1 year were highest in Hp 2-2 patients (P = 0.03 and 0.003, respectively). The Hp 2-2 type was associated with higher serum iron, transferrin saturation, and ferritin levels and with low vitamin C concentrations. Furthermore, ferritin concentrations were higher in HIV-infected patients than in controls (P < 0.0001). CONCLUSION: HIV-infected patients carrying the Hp 2-2 phenotype show a worse prognosis, which is reflected by a more rapid rate of viral replication (in the absence of antiviral treatment). They also accumulate more iron and oxidize more vitamin C, suggesting that less efficient protection against haemoglobin/iron-driven oxidative stress may be a direct mechanism for stimulating viral replication.

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Research works printed but not linked: 16

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Metadata

Authors
Sanders, V. J., Pittman, C. A., White, M. G., Wang, G., Wiley, C. A., & Achim, C. L.
Venue
AIDS
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-09
Volume
12
Issue
9
Pages
1021-1026
ISSN
0269-9370 (ISSN-L)
DOI
10.1097/00002030-199809000-00009
OpenAlex
W1981379366
Cited by
319
References
1
FWCI
7.03
Type
journal article
Language
en
Open access
closed

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