The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study
Abstract
Object. To determine the extent and duration of change in extracellular glutamate levels after human traumatic brain injury (TBI), 17 severely brain injured adults underwent implantation of a cerebral microdialysis probe and systematic sampling was conducted for 1 to 9 days postinjury. Methods. A total of 772 hourly microdialysis samples were obtained in 17 patients (median Glasgow Coma Scale score 5 ± 2.5, mean age 39.4 ± 20.4 years). The mean (± standard deviation) glutamate levels in the dialysate were evaluated for 9 days, during which the mean peak concentration reached 25.4 ± 13.7 (µM on postinjury Day 3. In each patient transient elevations in glutamate were seen each day. However, these elevations were most commonly seen on Day 3. In all patients there was a mean of 4.5 ± 2.5 transient elevations in glutamate lasting a mean duration of 4.4 ± 4.9 hours. These increases were seen in conjunction with seizure activity. However, in many seizure-free patients the increase in extracellular glutamate occurred when cerebral perfusion pressure was less than 70 mm Hg (p < 0.001). Given the potential injury-induced uncoupling of cerebral blood flow and metabolism after TBI, these increases in extracellular glutamate may reflect a degree of enhanced cellular crisis, which in severe head injury in humans appears to last up to 9 days. Conclusions. Extracellular neurochemical measurements of excitatory amino acids may provide a marker for secondary insults that can compound human TBI.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS
Teasdale, G., & Jennett, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91639-0 · Cited by 13,215
The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death
Choi, D. W., & Rothman, S. M. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001131 · Cited by 2,223
Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884
Ionic dependence of glutamate neurotoxicity
Choi, D. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00369.1987 · Cited by 1,802
Katayama, Y., Becker, D. P., Tamura, T., & Hovda, D. A. (1990) · Journal of Neurosurgery · doi:10.3171/jns.1990.73.6.0889 · Cited by 1,091
Self-citationCerebral perfusion pressure: management protocol and clinical results
Rosner, M. J., Rosner, S. D., & Johnson, A. H. (1995) · Journal of Neurosurgery · doi:10.3171/jns.1995.83.6.0949 · Cited by 963
Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain
During, M. J., & Spencer, D. D. (1993) · The Lancet · doi:10.1016/0140-6736(93)90754-5 · Cited by 902
Bouma, G. J., Muizelaar, J. P., Choi, S. C., Newlon, P. G., & Young, H. F. (1991) · Journal of Neurosurgery · doi:10.3171/jns.1991.75.5.0685 · Cited by 717
Globus, M. Y. ‐., Busto, R., Dietrich, W. D., Martinez, E., Valdes, I., & Ginsberg, M. D. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01111.x · Cited by 701
Hagberg, H., Lehmann, A., Sandberg, M., Nyström, B., Jacobson, I., & Hamberger, A. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.56 · Cited by 660
Cited by
Guidelines for the Evaluation and Management of Status Epilepticus
Neurocritical Care Society Status Epilepticus Guideline Writing Committee, Brophy, G. M., Bell, R., Claassen, J., Alldredge, B., Bleck, T. P., Glauser, T., LaRoche, S. M., Riviello, J. J., Shutter, L., et al. (2012) · Neurocritical Care · doi:10.1007/s12028-012-9695-z · Cited by 1,623
Self-citationPathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences
Bramlett, H. M., & Dietrich, W. D. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000111614.19196.04 · Cited by 631
Acute seizures after intracerebral hemorrhage: A factor in progressive midline shift and outcome
Vespa, P. M., O’Phelan, K., Shah, M., Mirabelli, J., Starkman, S., Kidwell, C., Saver, J., Nuwer, M. R., Frazee, J. G., McArthur, D. A., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000063316.47591.b4 · Cited by 561
Self-citationVespa, P. M., Miller, C., McArthur, D., Eliseo, M., Etchepare, M., Hirt, D., Glenn, T. C., Martin, N., & Hovda, D. (2007) · Critical Care Medicine · doi:10.1097/00003246-200712000-00023 · Cited by 451
Self-citationHillered, L., Vespa, P. M., & Hovda, D. A. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.3 · Cited by 365
Self-citation
Metadata
- Authors
- Vespa, P., Prins, M., Ronne-Engstrom, E., Caron, M., Shalmon, E., Hovda, D. A., Martin, N. A., & Becker, D. P.
- Venue
- Journal of Neurosurgery
- Published
- 1998-12
- Volume
- 89
- Issue
- 6
- Pages
- 971-982
- ISSN
- 0022-3085 (ISSN-L)
- OpenAlex
- W2085360535
- Cited by
- 334
- References
- 50
- FWCI
- 11.12
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study. https://app.cochat.ai/papers/10.3171/jns.1998.89.6.0971
- The paper
- Vespa, P., Prins, M., Ronne-Engstrom, E., Caron, M., Shalmon, E., Hovda, D. A., Martin, N. A., & Becker, D. P. (1998). Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study. Journal of Neurosurgery. https://doi.org/10.3171/jns.1998.89.6.0971
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
