From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition
Open accessAbstract
Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed.
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Similarities between autism and schizophrenia are such that results from animal models like the MIA model may be overlapping and confounded.
“Despite the differences between these two disorders, the similarities between them are such that results from animal models like the MIA model may be overlapping and confounded (Bauman et al, 2014;Young et al, 2016).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Young et al, 2016
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The Role of the Immune System in Autism Spectrum Disorder
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- Authors
- Young, A. M. H., Chakrabarti, B., Roberts, D., Lai, M.-C., Suckling, J., & Baron-Cohen, S.
- Affiliations
- University of Cambridge (GB)
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Young, Adam M. H.
- Venue
- Molecular Autism
- Published
- 2016-01-20
- Volume
- 7
- Issue
- 1
- Pages
- 9-9
- ISSN
- 2040-2392 (ISSN-L)
- PMC
- PMC4719563
- OpenAlex
- W2259658859
- Cited by
- 76
- References
- 115
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 10 · 2017: 11 · 2016: 7
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Autism (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- autism spectrum disorder, neuroinflammation, prenatal neurodevelopment, microglial activation, biomarkers, amniotic fluid, cerebrospinal fluid, serum biomarkers, brain parenchyma, neuronal morphology, autism etiology, neuroimaging, neuropathology, autism treatment
- MeSH terms
- Autism Spectrum Disorder, Amniotic Fluid, Animals, Haplorhini, Antigens, Surface, Autoantibodies, Body Fluids, Brain, Brain Chemistry, Female, HLA Antigens, Humans, Immunity, Maternally-Acquired, Inflammation, Lipopolysaccharides, Maternal-Fetal Exchange, Nerve Tissue Proteins, Neuroglia, Pregnancy, Pregnancy Complications, Infectious, Prenatal Exposure Delayed Effects, Signal Transduction, Cytokines, Glutamic Acid, Inflammation Mediators, Chemokines, Mice, Neuroimaging
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