Cited by 215Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesPharmacology and Obesity Treatment

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications

Mark, Allyn L., Correia, Marcelo L. G., Rahmouni, Kamal, Haynes, William G.·2002·Journal of Hypertension

DOI 10.1097/00004872-200207000-00001

Open this paper in CoChat — free account

Abstract

Leptin, an adipocyte secreted hormone, acts in the hypothalamus to inhibit appetite and promote thermogenic metabolism, thereby reducing adiposity and body weight. Leptin has multiple autonomic and cardiovascular actions, including sympathetic activation, increases in endothelium derived nitric oxide (NO), and angiogenesis. The predominant cardiovascular effect of chronic hyperleptinemia is a pressor effect mediated by increased sympathetic activity. The sympathetic and cardiovascular actions of leptin are discussed and evidence derived from studies of obese mice for the novel concept of selective leptin resistance is reviewed. This concept holds that in some obese states, there is preservation of the sympathoexcitatory actions of leptin despite resistance to the satiety and weight-reducing actions of the hormone. Selective leptin resistance might explain how hyperleptinemia could contribute to increases in sympathetic activity and arterial pressure in obese states where there is resistance to the metabolic (satiety and weight-reducing) actions of leptin. It is speculated here, that this concept may have potential implications for human obesity, which is often associated with elevated plasma leptin and partial resistance to the satiety effects of leptin. If selective leptin resistance occurs in obese humans, then leptin could contribute to the sympathetic overactivity and hypertension despite resistance to its metabolic actions.

Integrity signals

Registry

Crossref · 10.1097/00004872-200207000-00001

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346

Show all 45 references

Research works printed but not linked: 3

Mountjoy, 1994, Mol Endocrinol, 8, 1298, 10.1210/me.8.10.1298 · DOI
Morgan, 2001, Hypertens, 38, 478
Landsberg, 1986, Q J Med, 236, 1081

Sorted by citations

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737
Cardiac remodeling in obesity
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome
Kuo, L. E., Kitlinska, J. B., Tilan, J. U., Li, L., Baker, S. B., Johnson, M. D., Lee, E. W., Burnett, M. S., Fricke, S. T., Kvetnansky, R., et al. (2007) · Nature Medicine · doi:10.1038/nm1611 · Cited by 656
Obesity, Sleep Apnea, and Hypertension
Wolk, R., Shamsuzzaman, A. S. M., & Somers, V. K. (2003) · Hypertension · doi:10.1161/01.hyp.0000101686.98973.a3 · Cited by 532
Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins
Hall, J. E., da Silva, A. A., do Carmo, J. M., Dubinion, J., Hamza, S., Munusamy, S., Smith, G., & Stec, D. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.113175 · Cited by 528
Leptin resistance
Martin, S. S., Qasim, A., & Reilly, M. P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.060 · Cited by 516
Leptin and atherosclerosis
Bełtowski, J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.03.003 · Cited by 484
The cellular and molecular bases of leptin and ghrelin resistance in obesity
Cui, H., López, M., & Rahmouni, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.222 · Cited by 498
Self-citation
Leptin and Cardiovascular Disease
Koh, K. K., Park, S. M., & Quon, M. J. (2008) · Circulation · doi:10.1161/circulationaha.107.741645 · Cited by 481
Diabetes mellitus as a prothrombotic condition
Grant, P. J. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01824.x · Cited by 443
Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome
Thorp, A. A., & Schlaich, M. P. (2015) · Journal of Diabetes Research · doi:10.1155/2015/341583 · Cited by 425
“Pharmacological inhibition of sympathetic nerve activity to achieve sustained weight loss and improvements in insulin sensitivity, glucose tolerance, dyslipidemia, and hypertension is currently under intense investigation.”
Background
Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis
Huby, A.-C., Antonova, G., Groenendyk, J., Gomez-Sanchez, C. E., Bollag, W. B., Filosa, J. A., & de Chantemèle, E. J. B. (2015) · Circulation · doi:10.1161/circulationaha.115.018226 · Cited by 376
Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
Sahu, A. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.10.001 · Cited by 358
Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice
Barouch, L. A., Berkowitz, D. E., Harrison, R. W., O’Donnell, C. P., & Hare, J. M. (2003) · Circulation · doi:10.1161/01.cir.0000083716.82622.fd · Cited by 341
Leptin Signaling and Obesity
Yang, R., & Barouch, L. A. (2007) · Circulation Research · doi:10.1161/circresaha.107.156596 · Cited by 334
Leptin and hyperleptinemia - from friend to foe for cardiovascular function
Ren, J. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810001 · Cited by 305
Selective Insulin and Leptin Resistance in Metabolic Disorders
Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 320
Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset
Levin, B. E., Dunn-Meynell, A. A., & Banks, W. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00393.2003 · Cited by 269
Leptin-Aldosterone-Neprilysin Axis: Identification of Its Distinctive Role in the Pathogenesis of the Three Phenotypes of Heart Failure in People With Obesity
Packer, M. (2018) · Circulation · doi:10.1161/circulationaha.117.032474 · Cited by 263
Sympathetic system activity in obesity and metabolic syndrome
TENTOLOURIS, N., LIATIS, S., & KATSILAMBROS, N. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.010 · Cited by 260
The role of leptin in leptin resistance and obesity
Zhang, Y., & Scarpace, P. J. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.038 · Cited by 259
The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
Guarino, D., Nannipieri, M., Iervasi, G., Taddei, S., & Bruno, R. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00665 · Cited by 259
Plasma leptin and prognosis in patients with established coronary atherosclerosis
Wolk, R. A., Berger, P. B., Lennon, R. J., Brilakis, E. S., Johnson, B. D., & Somers, V. K. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.050 · Cited by 235
Role of leptin in blood pressure regulation and arterial hypertension
Bełtowski, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000222743.06584.66 · Cited by 220
Adipokines, diabetes and atherosclerosis: an inflammatory association
Freitas‐Lima, L. C., Braga, V. A., de França-Silva, M. D. S., Cruz, J. C., Santos, S. H. S., Monteiro, M. M. D. O., & Balarini, C. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00304 · Cited by 218
Adipose tissue hormones
Guerre-Millo, M. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344048 · Cited by 215
The role of leptin in leptin resistance and obesity
Enriori, P. J., Evans, A. E., Sinnayah, P., & Cowley, M. A. (2006) · Obesity · Cited by 197
The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction
Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 213
Paraventricular nucleus, stress response, and cardiovascular disease
Benarroch, E. E. (2005) · Clinical Autonomic Research · doi:10.1007/s10286-005-0290-7 · Cited by 170
Selective leptin resistance revisited
Mark, A. L. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00180.2013 · Cited by 162
Self-citation
Obesity-related hypertension: possible pathophysiological mechanisms
Vaněčková, I., Maletı́nská, L., Behuliak, M., Pražienková, V., Zicha, J., & Kuneš, J. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0368 · Cited by 168
Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses
Radin, M. J., Sharkey, L. C., & Holycross, B. J. (2009) · Veterinary Clinical Pathology · doi:10.1111/j.1939-165x.2009.00133.x · Cited by 173
Leptin, obesity and cardiovascular disease
Correia, M., & Haynes, W. G. (2004) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200403000-00010 · Cited by 153
Self-citation
Getting the message across: mechanisms of physiological cross talk by adipose tissue
Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 140
Programming of adult cardiovascular function after early maternal undernutrition in sheep
Gopalakrishnan, G. S., Gardner, D. S., Rhind, S. M., Rae, M. T., Kyle, C. E., Brooks, A. N., Walker, R. M., Ramsay, M., Keisler, D. H., Stephenson, T. J., et al. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00687.2003 · Cited by 134
Hypertension in Obesity
Kurukulasuriya, L. R., Stas, S. N., Lastra, G., Manrique, C. M., & Sowers, J. R. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.06.004 · Cited by 130
Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy
Burwell, R. G., Aujla, R. K., Grevitt, M. P., Dangerfield, P., Moulton, A., Randell, T. L., & Anderson, S. (2009) · Scoliosis · doi:10.1186/1748-7161-4-24 · Cited by 130
Serum markers of bone turnover are increased at six and 18 months after Roux-en-Y bariatric surgery: correlation with the reduction in leptin
Bruno, C., Fulford, A. D., Potts, J. R., McClintock, R., Jones, R., Cacucci, B. M., Gupta, C. E., Peacock, M., & Considine, R. V. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0265 · Cited by 121
Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes
MADANI, S., DEGIROLAMO, S., MUNOZ, D., LI, R., & SWEENEY, G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.022 · Cited by 122
Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases
Fortuño, A., Rodrı́guez, A., Gómez‐Ambrosi, J., Frühbeck, G., & Dı́ez, J. (2003) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179868 · Cited by 123
Subcutaneous obesity is not associated with sympathetic neural activation
Alvarez, G. E., Ballard, T. P., Beske, S. D., & Davy, K. P. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01046.2003 · Cited by 121
High Dietary Sodium Intake Increases White Adipose Tissue Mass and Plasma Leptin in Rats
Fonseca‐Alaniz, M. H., Brito, L. C., Borges‐Silva, C. N., Takada, J., Andreotti, S., & Lima, F. B. (2007) · Obesity · doi:10.1038/oby.2007.261 · Cited by 121
OMEGA‐3 FATTY ACIDS AND HYPERTENSION IN HUMANS
Mori, T. A. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04451.x · Cited by 121
A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity
Hilzendeger, A. M., Morgan, D. A., Brooks, L. A., Dellsperger, D., Liu, X., Grobe, J. L., Rahmouni, K., Sigmund, C. D., & Mark, A. L. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00974.2011 · Cited by 118
Self-citation
Oxidative stress, nitric oxide production, and renal sodium handling in leptin-induced hypertension
Bełtowski, J., Wójcicka, G., Marciniak, A., & Jamroz, A. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.10.029 · Cited by 118
Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents
Mendoza, J. M. G., Amador‐Licona, N., Flores-Martínez, S. E., López-Cardona, M. G., Ahuatzin-Trémary, R., & Sánchez‐Corona, J. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001824 · Cited by 109
Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea
Kapsimalis, F., Varouchakis, G., Manousaki, A., Daskas, S., Nikita, D., Kryger, M. H., & Gourgoulianis, K. I. (2008) · Lung · doi:10.1007/s00408-008-9082-x · Cited by 108
Autonomic Nervous System in Obesity and Insulin-Resistance—The Complex Interplay between Leptin and Central Nervous System
Russo, B., Menduni, M., Borboni, P., Picconi, F., & Frontoni, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105187 · Cited by 116
Impaired lung function and serum leptin in men and women with normal body weight: a population based study
Sin, D. D. (2003) · Thorax · doi:10.1136/thorax.58.8.695 · Cited by 103
Stressed brain, diseased heart: A review on the pathophysiologic mechanisms of neurocardiology
Pereira, V., Cerqueira, J., Palha, J. A., & Sousa, N. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.165 · Cited by 107
Diabetic Hypertensive Leptin Receptor–Deficient db/db Mice Develop Cardioregulatory Autonomic Dysfunction
Gonçalves, A. C. D. C., Tank, J., Diedrich, A., Hilzendeger, A. M., Plehm, R., Bäder, M., Luft, F. C., Jordan, J., & Groß, V. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.124776 · Cited by 96
PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
Crosson, S. M., Khan, A. H., Printen, J. A., Pessin, J. E., & Saltiel, A. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17975 · Cited by 95
How adiponectin, leptin, and ghrelin orchestrate together and correlate with the severity of nonalcoholic fatty liver disease
Machado, M. V., Coutinho, J., Carepa, F., Costa, A., Proença, H., & Cortez‐Pinto, H. (2012) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32835609b0 · Cited by 92
Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults
Brook, R. D., Bard, R. L., Glazewski, L., Kehrer, C., Bodary, P. F., Eitzman, D. T., & Rajagopalan, S. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.01.009 · Cited by 88
Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells
Singh, P., Peterson, T. E., Barber, K. R., Kuniyoshi, F. H. S., Jensen, A., Hoffmann, M. S., Shamsuzzaman, A., & Somers, V. K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.158 · Cited by 87
The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective
Pereira, J. A. D. S., Corrêa‐da‐Silva, F., & Moraes‐Vieira, P. M. (2017) · Journal of Diabetes Research · doi:10.1155/2017/4527980 · Cited by 90
Effect of Weight Loss on Predicted Cardiovascular Risk: Change in Cardiac Risk After Bariatric Surgery
Batsis, J. A., Romero‐Corral, A., Collazo–Clavell, M. L., Sarr, M. G., Somers, V. K., Brekke, L. N., & López-Jiménez, F. A. (2007) · Obesity · doi:10.1038/oby.2007.589 · Cited by 83
Neuroprotective effects of leptin in the context of obesity and metabolic disorders
Davis, C., Mudd, J., & Hawkins, M. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.012 · Cited by 84
Atherosclerosis and Coronary Artery Disease
Zaromitidou, M., Siasos, G., Παπαγεωργίου, Ν., Oikonomou, E. K., & Tousoulis, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803312-8.00002-1 · Cited by 82
Distinct effects of short- and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes
Palanivel, R., Eguchi, M., Shuralyova, I., Coe, I. R., & Sweeney, G. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.020 · Cited by 72
A Critical Evaluation of the Fetal Origins Hypothesis and Its Implications for Developing Countries
Adair, L. S., & Prentice, A. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.191 · Cited by 68
Leptin protects H9c2 rat cardiomyocytes from H2O2‐induced apoptosis
Eguchi, M., Liu, Y.-T., Shin, E., & Sweeney, G. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06465.x · Cited by 67
Circumventricular organs: Targets for integration of circulating fluid and energy balance signals?
Mimee, A., Smith, P., & Ferguson, A. V. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.012 · Cited by 68
Leptin Stimulates Both Endothelin-1 and Nitric Oxide Activity in Lean Subjects But Not in Patients With Obesity-Related Metabolic Syndrome
Schinzari, F., Tesauro, M., Rovella, V., Daniele, N. D., Mores, N., Veneziani, A., & Cardillo, C. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3424 · Cited by 66
Historic and Early Life Origins of Hypertension in Africans
Forrester, T. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.211 · Cited by 65
Mineralocorticoid receptor activation in obesity hypertension
Nagase, M., & Fujita, T. (2009) · Hypertension Research · doi:10.1038/hr.2009.86 · Cited by 64
Central regulation of energy balance: inputs, outputs and leptin resistance
Arch, J. R. S. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004407 · Cited by 62
Leptin as a new diagnostic tool in chronic heart failure
Schulze, P. C., & Kratzsch, J. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.05.019 · Cited by 62
Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in hypertensive African women with increased adiposity: the POWIRS study
Schutte, R., Huisman, H. W., Schutte, A. E., & Malan, N. T. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001856 · Cited by 61
Skeletal effects of bariatric surgery: examining bone loss, potential mechanisms and clinical relevance
Scibora, L. M. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12363 · Cited by 63
Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction
Knudson, J. D., Dinçer, Ü. D., Dick, G. M., Shibata, H., Akahane, R., Saito, M., & Tune, J. D. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00244.2005 · Cited by 60
Implications of myocardial matrix remodeling by adipokines in obesity-related heart failure
Schram, K., & Sweeney, G. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2008.10.001 · Cited by 59
Obesity and heart rate variability in men with myocardial infarction.
Piestrzeniewicz, K., Łuczak, K., Lelonek, M., Wranicz, J. K., & Goch, J. H. (2008) · PubMed · Cited by 59
Intermittent Fasting Induces Hypothalamic Modifications Resulting in Low Feeding Efficiency, Low Body Mass and Overeating
Chausse, B., Solon, C., da Silva, C. C. C., dos Reis, I. G. M., Manchado-Gobatto, F. D. B., Gobatto, C. A., Velloso, L. A., & Kowaltowski, A. J. (2014) · Endocrinology · doi:10.1210/en.2013-2057 · Cited by 59
Deleterious effects of high-fat diet on perinatal and postweaning periods in adult rat offspring
Parente, L. B., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.05.005 · Cited by 59
Differential leptin access into the brain — A hierarchical organization of hypothalamic leptin target sites?
Münzberg, H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.020 · Cited by 61
Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems
Kasper, S. O., Carter, C. S., Ferrario, C. M., Ganten, D., Ferder, L., Sonntag, W. E., Gallagher, P. E., & Diz, D. I. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00163.2005 · Cited by 57
Hypertension and impaired renal function accompany juvenile obesity: The effect of prenatal diet
Williams, P. J., Kurlak, L. O., Perkins, A. C., Budge, H., Stephenson, T. J., Keisler, D. H., Symonds, M. E., & Gardner, D. S. (2007) · Kidney International · doi:10.1038/sj.ki.5002276 · Cited by 57
Central and peripheral leptin resistance in obesity and improvements of exercise
Peng, J., Yin, L., & Wang, X. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105006 · Cited by 63
Effect of fish diets and weight loss on serum leptin concentration in overweight, treated-hypertensive subjects
Mori, T. A., Burke, V., Puddey, I. B., Shaw, J. E., & Beilin, L. J. (2004) · Journal of Hypertension · doi:10.1097/00004872-200410000-00022 · Cited by 55
Obesity and hypertension in children and adolescents
Jeong, S. I., & Kim, S. H. (2024) · Clinical Hypertension · doi:10.1186/s40885-024-00278-5 · Cited by 74
The leptin/adiponectin ratio: Potential implications for peritoneal dialysis
Teta, D., Maillard, M. P., Halabi, G., & Burnier, M. (2008) · Kidney International · doi:10.1038/sj.ki.5002611 · Cited by 52
Circulating Leptin and Angiogenic Factors in Preeclampsia Patients
Nakatsukasa, H., Masuyama, H., Takamoto, N., & Hiramatsu, Y. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-136 · Cited by 51
Hypertension in Obesity
Kurukulasuriya, L. R., Stas, S. N., Lastra, G., Manrique, C. M., & Sowers, J. R. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.06.002 · Cited by 48
Long-term AT1receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats
Gilliam‐Davis, S., Payne, V. S., Kasper, S. O., Tommasi, E. N., Robbins, M. E. C., & Diz, D. I. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00457.2007 · Cited by 47
Selective Deletion of Leptin Signaling in Endothelial Cells Enhances Neointima Formation and Phenocopies the Vascular Effects of Diet-Induced Obesity in Mice
Hubert, A., Bochenek, M. L., Schütz, E., Gogiraju, R., Münzel, T. F., & Schäfer, K. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309798 · Cited by 47
Obesity, Weight Loss, and Vascular Function
Brook, R. D. (2006) · Endocrine · doi:10.1385/endo:29:1:21 · Cited by 47
Leptin increase is associated with markers of the hemostatic system in obese healthy women
Guagnano, M. T., Romano, M., Falco, A., Nutini, M., Marinopiccoli, M., Manigrasso, M. R., Basili, S., & Davı̀, G. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00445.x · Cited by 44
Molecular Genetics of Experimental Hypertension and the Metabolic Syndrome
Pravenec, M., & Kurtz, T. W. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.086900 · Cited by 48
Leptin and the clinical cardiovascular risk
Singh, M., Bedi, U. S., Singh, P. P., Arora, R. R., & Khosla, S. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.07.019 · Cited by 44
The association between leptin and left ventricular hypertrophy
Pladevall, M., Williams, K. L., Guyer, H., Sadurní, J. R., Falces, C., Ribes, A., Paré, C., Brotons, C., Gabriel, R., Serrano‐Ríos, M., et al. (2003) · Journal of Hypertension · doi:10.1097/00004872-200308000-00009 · Cited by 42
Leptin regulation of lipid homeostasis: dietary and metabolic implications
Houseknecht, K. L., & Spurlock, M. E. (2003) · Nutrition Research Reviews · doi:10.1079/nrr200256 · Cited by 44
Factors that influence the risk of hypertension in obese individuals
Coatmellec-Taglioni, G., & Ribière, C. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200305000-00013 · Cited by 44
Food for Thought: Hormonal, Experiential, and Neural Influences on Feeding and Obesity
Karatsoreos, I. N., Thaler, J. P., Borgland, S. L., Champagne, F. A., Hurd, Y. L., & Hill, M. N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3452-13.2013 · Cited by 44
Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity
Badoer, E., Kosari, S., & Stebbing, M. J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00321 · Cited by 36
Control of metabolic and cardiovascular function by the leptin–brain melanocortin pathway
do Carmo, J. M., da Silva, A. A., Dubinion, J., Sessums, P. O., Ebaady, S. H., Wang, Z., & Hall, J. E. (2013) · IUBMB Life · doi:10.1002/iub.1187 · Cited by 36
Central Nervous System Dysfunction in Obesity-Induced Hypertension
Head, G. A., Lim, K., Barzel, B., Burke, S. L., & Davern, P. J. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0466-4 · Cited by 37
Cardiovascular Actions of Leptin in the Subfornical Organ are Abolished by Diet‐Induced Obesity
Smith, P., & Ferguson, A. V. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02257.x · Cited by 35
Factors Responsible for Obesity-Related Hypertension
Lim, K., Jackson, K. L., Sata, Y., & Head, G. A. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0750-1 · Cited by 35
Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans
El‐Gharbawy, A. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)03089-3 · Cited by 34

Authors: Mark, A. L., Correia, M. L. G., Rahmouni, K., & Haynes, W. G.
Affiliations: University of Iowa (US)
Universidade do Estado do Rio de Janeiro (BR)
Corresponding author: Mark, Allyn L.
ORCID: Mark, Allyn L.
Correia, Marcelo L. G.
Rahmouni, Kamal
Haynes, William G.
Venue: Journal of Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-07
Volume: 20
Issue: 7
Pages: 1245-1250
ISSN: 0263-6352 (ISSN-L)
DOI: 10.1097/00004872-200207000-00001
OpenAlex: W1964056978
Cited by: 215
References: 45
Citations by year: 2026: 1 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 14 · 2013: 7 · 2012: 7
FWCI: 2.23
Type: journal article
Language: en
Open access: closed
Locations: Journal of Hypertension (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50hl044546-05)
National Heart, Lung, and Blood Institute (HL-44546)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Keywords: leptin, leptin resistance, hyperleptinemia, obesity, sympathetic nervous system, hypertension, satiety, thermogenesis, endothelial nitric oxide, angiogenesis, arterial pressure
MeSH terms: Animals, Appetite Regulation, Cardiovascular System, Drug Resistance, Humans, Obesity, Sympathetic Nervous System, Weight Loss, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks