Cited by 112Sleep and Wakefulness ResearchSleep and Work-Related FatigueCircadian rhythm and melatonin

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Effects of Sleep on the Production of Cytokines in Humans

Uthgenannt, Dirk, Schoolmann, Detlef, Pietrowsky, Reinhard, Fehm, Horst-Lorenz, Born, Jan·1995·Psychosomatic Medicine

DOI 10.1097/00006842-199503000-00001

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Abstract

The restorative functions of sleep may affect immunologic functioning. The present study examined the effects of sleep on stimulated cytokine release in 13 healthy men. The subjects spent 2 experimental nights in the sleep laboratory. In one condition, lights were turned off at 11:00 PM to enable sleep for 3.5 hours. Thereafter, they stayed awake till 7:00 AM. In the other condition, conversely, subjects stayed awake between 11:00 PM and 3:00 AM. Then, lights were turned off for a 3.5-hour phase of sleep. Blood was sampled every 30 minutes between 11:00 PM and 7:00 AM. Sleep was monitored by polysomnographic recordings. Release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) was determined after stimulation of mononuclear cells with lipopolysaccharide from Escherichia coli. The release of IL-2 was stimulated with phytohemagglutinin. Compared with wakefulness, after 3 hours of sleep, production of TNF-alpha and IL-1 beta was substantially diminished (p < .01). Production of IL-2 was enhanced during sleep (p < .05), with this effect being limited to the second nocturnal sleep phase after 3:00 AM. Sleep-dependent changes in stimulated cytokine release were independent of changes in plasma cortisol concentrations. These results indicate a specific reducing effect of sleep (vs. wakefulness) on cytokine production by monocytes (TNF-alpha and IL-1 beta). The rather slow development of the effects calls for further studies to establish the exact time course of the influence of sleep on cytokine production.

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Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Figari, I. S., Palladino, M. A., & O'Connor, J. V. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.6.1433 · Cited by 1,472
Effects of stress on the immune system
Khansari, D. N., Murgo, A. J., & Faith, R. E. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90069-l · Cited by 673
Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.
Nedwin, G. E., Svedersky, L. P., Bringman, T. S., Palladino, M. A., & Goeddel, D. V. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.4.2492 · Cited by 484
Lymphokines
Dinarello, C. A., & Mier, J. W. (1987) · New England Journal of Medicine · doi:10.1056/nejm198710083171506 · Cited by 476
Stress-Induced Suppression of Immunity in Adrenalectomized Rats
Keller, S. E., Weiss, J. M., Schleifer, S. J., Miller, N. E., & Stein, M. (1983) · Science · doi:10.1126/science.6612346 · Cited by 390
Effects of sleep deprivation on human immune functions
Moldofsky, H., Lue, F. A., Davidson, J. R., & Gorczynski, R. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.8.2785942 · Cited by 250
The relationship of interleukin-1 and immune functions to sleep in humans.
Moldofsky, H., Lue, F. A., Eisen, J. S., Keystone, E., & Gorczynski, R. M. (1986) · Psychosomatic Medicine · doi:10.1097/00006842-198605000-00001 · Cited by 229
Lymphocyte and Granulocyte Reactions during Sleep Deprivation
Palmblad, J. E. W., Petrini, B., Wasserman, J., & Åkerstedt, T. (1979) · Psychosomatic Medicine · doi:10.1097/00006842-197906000-00001 · Cited by 208
Stressor exposure and immunological response in man: Interferon-producing capacity and phagocytosis
Palmblad, J. E. W., Cantell, K., Strander, H. A., Fröberg, J. E., Karlsson, C.-G., Levi, L., Granström, M., & Unger, P. (1976) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(76)90020-9 · Cited by 148

Show all 23 references

Research works printed but not linked: 7

Kapas, 1992, Am J Physiol, 263, R703
Shoham, 1987, Am J Physiol, 253, R142
Krueger, 1984, Am J Physiol, 246, R994
Krueger, 1990, Yale J Biol Med, 63, 157
Casey, 1974, Reticuloendothelial Soc J, 15, 87
Everson, 1993, Sleep Res, 22, 462
Ritter, 1977, Immunology, 33, 241

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Krueger, J. M., Opp, M. R., Toth, L. A., Johannsen, L., & Kapás, L. (1990) · Current topics in neuroendocrinology · doi:10.1007/978-3-642-75837-9_10 · Cited by 8
Effects of night shift working on some immunological, prostate specific antigen, cortisol level and malondialdehyde in male nurses at Hawler city
Muhammad, D. H., & Qadir, F. A. (2017) · AIP conference proceedings · doi:10.1063/1.5004312 · Cited by 6
Sleep associated endocrine and immune changes in the elderly
Perras, B., & Jan Born, A. (2005) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(04)17005-3 · Cited by 6
Subdiaphragmatic vagotomy does not block sleep deprivation-induced sleep in rats
Hansen, M. K., & Krueger, J. M. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00088-2 · Cited by 6
Cytokine Involvement in Sleep Responses to Infection and Physiological Sleep
Krueger, J. M. (1996) · Neuroscience intelligence unit · doi:10.1007/978-1-4615-9695-0_4 · Cited by 6
Improving sleep quality in patients with chronic illness.
Cruess, D. G. (2002) · American Psychological Association eBooks · doi:10.1037/10475-010 · Cited by 6
Essentials of Sleep Neuropharmacology
Bianchi, M. T. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1703-7.10005-2 · Cited by 5
Salivary Interleukin 1-Beta Concentration Associates With Sleep Quality in Older Individuals
Valle, V. I.-D., Ballestar‐Tarín, M. L., Mafla-España, M. A., Cauli, O., & Navarro-Martínez, R. (2023) · Biological Research For Nursing · doi:10.1177/10998004231181347 · Cited by 3
Sleep Loss: What Does It Do to Our Brain and Body?
Jha, V. M., & Jha, S. K. (2020) · Springer eBooks · doi:10.1007/978-981-15-7175-6_4 · Cited by 4
ICU Environmental Factors and Quality of Sleep in Critically III Patients
Grasso, S., Mascia, L., & Ranieri, V. M. (2003) · Springer eBooks · doi:10.1007/978-3-642-55733-0_11 · Cited by 2
Host Defense
Krueger, J. M., & Majde, J. A. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50028-8 · Cited by 2
Cytokines and Sleep Regulation
Fang, J., & Krueger, J. G. (1998) · CRC Press eBooks · doi:10.1201/9781420048247.ch35 · Cited by 2
Immune Activity and Psychopathology
Daruna, J. H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382049-5.00010-3 · Cited by 1
Cytokines and Sleep: Neuro-Immune Interactions and Regulations
Kushikata, T., Yoshida, H., & Yasuda, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-69146-6_8 · Cited by 1
Chrono-Immunotherapy with Interleukin-2 for Treatment of Metastatic Renal Cell Carcinoma: A Phase I-II Study
Re, G. L., Santeufemia, D. A., Talamini, R., Marus, W., Doretto, P., Falda, A., Nicolosi, G. L., Garbeglio, A., Sulfaro, S., & Tumolo, S. (2014) · Cited by 1
Correlation of Tough Tacrolimus Level with Early Acute Rejections in Renal Allograft Recipients- A Prospective Study
Tripathi, M. K. (2018) · Interventions in Gynaecology and Women’s Healthcare · doi:10.32474/igwhc.2018.01.000111 · Cited by 1
To Sleep, Perchance To Eat
Drange, M. R., & Melmed, S. K. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.5.1311 · Cited by 1
Selected genetic polymorphisms of epidermal growth factor, dopamine-2 receptor, neuregulin-1 and inflammatory cytokines in schizophrenia
Hänninen, K. (2014) · Tampere University Institutional Repository (Tampere University) · Cited by 1
DO SLEEP DIMENSIONS PREDICT PRIMARY AND SECONDARY ANTIBODY RESPONSES TO VACCINATION
Prather, A. A. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
Immunologische Funktionen des Schlafentzugs
Jan Born, A., & Fehm, H. L. (1996) · Springer eBooks · doi:10.1007/978-3-7091-6889-9_117
Self-citation
Chapter 8 CYTOKINES AND SLEEP REGULATION
Krueger, J. M., & Churchill, L. (2003)

Authors: Uthgenannt, D., Schoolmann, D., Pietrowsky, R., Fehm, H.-L., & Born, J.
Affiliations: University of Lübeck (DE)
Venue: Psychosomatic Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1995
Volume: 57
Issue: 2
Pages: 97-104
ISSN: 0033-3174 (ISSN-L)
DOI: 10.1097/00006842-199503000-00001
OpenAlex: W2322010248
Cited by: 112
References: 23
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 5
FWCI: 4.06
Type: journal article
Language: en
Open access: closed
Locations: Psychosomatic Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep, cytokine production, TNF-α, IL-1β, interleukin-2, monocytes, lipopolysaccharide stimulation, phytohemagglutinin stimulation, cortisol, wakefulness, immune function
MeSH terms: Adult, Circadian Rhythm, Humans, Hydrocortisone, Interleukin-1, Interleukin-2, Male, Sleep, Sleep Deprivation, Sleep Stages, Tumor Necrosis Factor-alpha, Cytokines

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Effects of Sleep on the Production of Cytokines in Humans

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