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Cited by 117Retinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis

Morphometric analysis of the macula in eyes with geographic atrophy due to age-related macular degeneration

KIM, S. Y., SADDA, S., HUMAYUN, M. S., de JUAN, E., MELIA, B. M., GREEN, W. R.·2002·Retina
DOI 10.1097/00006982-200208000-00011
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Abstract

PURPOSE: To evaluate the extent of neural cell death in eyes with geographic atrophy (GA). METHODS: Ten eyes with GA and five age-matched control eyes were selected for morphometric analysis. The nuclei of the ganglion cell, inner nuclear, and outer nuclear layers were counted in contiguous 100-microm segments from 1,500 microm nasal to 1,500 microm temporal to the fovea. RESULTS: The outer nuclear layer was most severely attenuated in eyes with GA, demonstrating a 76.9% reduction relative to control eyes (P < 0.0001). A significant loss of ganglion cells (by 30.7%) was also observed (P = 0.0008). There was no significant difference in the inner nuclear layer cells (P = 0.30). Among the GA eyes, the nuclei in all three layers were significantly reduced in segments in which the retinal pigment epithelium was completely absent (P </= 0.0003). CONCLUSION: Although the nuclei of the outer nuclear layer in eyes with GA were markedly attenuated, the nuclei of the inner nuclear layer were relatively preserved. There was also a significant reduction in ganglion cells in GA eyes, but considerable numbers remained even in the areas of complete retinal pigment epithelium atrophy. This finding suggests that therapies aimed at replacing outer nuclear function (such as neural retinal and retinal pigment epithelium transplantation or implantation of the intraocular retinal prosthesis) may be feasible for restoring vision in these patients.

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Crossref · 10.1097/00006982-200208000-00011

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25 of 25 references verified0 citation errors · 0 not checkable

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  • Hemorrhages, exudates, and neovascular fibrous tissue may replace normal retinal architecture and result in photoreceptor atrophy.

    “Hemorrhages, exudates, and neovascular fibrous tissue may replace normal retinal architecture and result in photoreceptor atrophy (Green, 1999; Kim et al., 2002).”

    From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Kim et al., 2002

  • Although the retinal pigment epithelium is the most affected cell type, the retinal outer nuclear layer is severely affected in geographic atrophy, with a 77% reduction compared with age-matched control eyes.

    “Although the retinal pigment epithelium is the most affected cell type, the retinal outer nuclear layer is severely affected, with a 77% reduction compared with age-matched control eyes.127”

    From Age-related macular degeneration (2008) · cites this paper as [127]

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Authors
KIM, S. Y., SADDA, S., HUMAYUN, M. S., de JUAN, E., MELIA, B. M., & GREEN, W. R.
Affiliations
Johns Hopkins University (US)
ORCID
HUMAYUN, M. S.
Venue
Retina
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-08
Volume
22
Issue
4
Pages
464-470
ISSN
0275-004X (ISSN-L)
DOI
10.1097/00006982-200208000-00011
OpenAlex
W2019087770
Cited by
117
References
25
Citations by year
2026: 2 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 6
FWCI
2.92
Type
journal article
Language
en
Open access
closed
Locations
  • Retina (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords
geographic atrophy, age-related macular degeneration, retinal ganglion cell death, outer nuclear layer, inner nuclear layer, retinal pigment epithelium atrophy, retinal cell death, retinal morphometry, retinal transplantation, retinal prosthesis
MeSH terms
Aged, Aged, 80 and over, Atrophy, Cell Count, Female, Humans, Interneurons, Macula Lutea, Macular Degeneration, Male, Middle Aged, Pigment Epithelium of Eye, Retinal Ganglion Cells

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